Results 131 to 140 of about 165,231 (306)

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

The protein interaction network mediated by human SH3 domains [PDF]

, 2012
Families of conserved protein domains, specialized in mediating interactions with short linear peptide motifs, are responsible for the formation of a variety of dynamic complexes in the cell.
PAOLUZI, SERENA, Luisa Castagnoli, Johannes Zerweck, Zerweck, J, CASTAGNOLI, LUISA, Costa, S, Perfetto, L, Martina Carducci, Castagnoli, L, Livia Perfetto, Stefano Costa, COSTA, SILVIO, Briganti, L, Mike Schutkowski, Serena Paoluzi, Cesareni, G, CESARENI, GIOVANNI, Gianni Cesareni, Paoluzi, S, Schutkowski, M, Carducci, M, Leonardo Briganti   +21 more
core   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Functional Diversity and Structural Disorder in the Human Ubiquitination Pathway [PDF]

, 2013
The ubiquitin-proteasome system plays a central role in cellular regulation and protein quality control (PQC). The system is built as a pyramid of increasing complexity, with two E1 (ubiquitin activating), few dozen E2 (ubiquitin conjugating) and several
Mainak Guharoy, Rita Pancsa (173029), Pallab Bhowmick, Tompa, Péter, Pallab Bhowmick (416342), Peter Tompa, Bhowmick, Pallab, Pancsa Rita, Guharoy Mainak, Bhowmick Pallab, Tompa Peter, Guharoy, Majnak, Mainak Guharoy (416343), Peter Tompa (38445), Rita Pancsa, Pancsa, Rita   +15 more
core   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

L'Enzim deubiqüitinant USP25: cerca de substrats i relació estructura-funció [PDF]

, 2007
[cat] La degradació de proteïnes mitjançant el sistema de les ubiquitines i el proteasoma (UPS) és un procés altament regulat, en el qual diverses famílies enzimàtiques s'encarreguen de la correcte conjugació i deconjugació de molècules d'ubiquitina a un
Bosch Comas, Anna
core  

Conserved and variable correlated mutations in the plant MADS protein network [PDF]

, 2010
Background Plant MADS domain proteins are involved in a variety of developmental processes for which their ability to form various interactions is a key requisite.
Dijk, A.D.J., van, van Dijk Aalt DJ, Roeland CHJ van Ham, Ham, R.C.H.J., van, van Dijk, A.D.J., van Ham, R.C.H.J., Aalt DJ van Dijk, van Ham Roeland CHJ   +7 more
core   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

iLIR : a web resource for prediction of Atg8-family interacting proteins [PDF]

, 2014
Macroautophagy was initially considered to be a nonselective process for bulk breakdown of cytosolic material. However, recent evidence points toward a selective mode of autophagy mediated by the so-called selective autophagy receptors (SARs).
Nezis, I. P., Osgood, Richard, Mulakkal, Nitha Charles, Promponas, Vasilis J., Kalvari, Ioanna, Johansen, Terje, Tsompanis, Stelios   +6 more
core   +1 more source

Modular RNA interactions shape FXR1 condensates involved in mRNA localization and translation

Nature Communications
Biomolecular condensates are found throughout a diversity of eukaryotic cell types and cellular compartments, playing roles in various cellular functions. A given protein generally forms functionally and compositionally heterogeneous condensates, but the
Jiabin Yang, Zhongyang Chen, Jiayin He, Binbin Zou, Yanmin Si, Yanni Ma, Jia Yu   +6 more
doaj   +1 more source