Results 261 to 270 of about 165,231 (306)

HNRNPD Induces Radioresistance in Nasopharyngeal Carcinoma by Sequestering GRAMD4 mRNA in Stress Granules

Advanced Science, EarlyView.
HNRNPD promotes radioresistance in nasopharyngeal carcinoma by enhancing stress granule assembly and sequestering GRAMD4 mRNA. This suppresses GRAMD4 translation and inhibits mitochondrial apoptosis. Targeting the integrated stress response with ISRIB restores GRAMD4 expression and sensitizes tumors to radiotherapy, revealing a translational control ...
Yingzi Li, Tong Xiang, Yuanyuan Liu, Desheng Weng, Jingjing Zhao, Hao Chen, Yan Tang, Songzuo Xie, Hao Zhang, Jun Luo, Xinyi Yang, Qiuzhong Pan, Muping Di, Jianchuan Xia   +13 more
wiley   +1 more source

Structure-driven function of plant lncRNAs: conserved RNA architectures in transcriptional and post-transcriptional regulation. [PDF]

RNA Biol
Shen Y, Dong Q, Ding Y, Zhang H.
europepmc   +1 more source

A Bioinspired Three‐Dimensional High‐Curvature Nano‐Interface Integrated Microfluidic Chip for Small Extracellular Vesicles Enrichment and Machine Learning‐Assisted Prostate Cancer Precision Diagnosis

Advanced Science, EarlyView.
A biotin‐modified artificial insertion peptide functionalized three‐dimensional high‐curvature‐TiO2 nano‐interface was engineered in a microfluidic chip to improve the isolation efficiency of small extracellular vesicles (sEVs). This chip balanced affinity, releasability, and extendibility, enabling high‐throughput recovery of sEVs for downstream ...
Le Wang, Yizhong Liang, Manan Sulaiman, Jiaqi Du, Ming Jiang, Zhihua Wang, Xu Yu, Li Xu   +7 more
wiley   +1 more source

Genome-wide identification and characterization of the RNAi gene families in Brassica rapa L. highlighting their regulatory components and underlying functions involving crop improvement. [PDF]

BMC Genom Data
Akond Z, Habib SH, Ahmed FF, Mollah MNH.
europepmc   +1 more source

Dose‐Dependent Reprogramming of Chromatin Accessibility by SOX4 Drives the Transcriptional Response to Iron Overload

Advanced Science, EarlyView.
This study demonstrates that iron overload triggers widespread chromatin compaction and transcriptional repression in human granulosa cells, recapitulating features of endometriosis. The epigenetic reprogramming is orchestrated by a TFEB‐SOX4‐SWI/SNF axis, with SOX4 acting as a central, dosage‐sensitive regulator.
Feifei Li, Yaoqiu Wu, Guangyu Yang, Jingyi Lai, Xiaoyue Sun, Liyan Wang, Xiaoli Li, Jing Zhang, Qingxue Zhang, Hui Chen, Haiyan Lin, Bingxiang Xu, Junfeng Zhang, Hailong Wang, Anming Meng, Chunwei Cao   +15 more
wiley   +1 more source

Weak Phd2-Hif-1α Affinity Coupled with High Basal Expression Is Predicted to Enhance HIF Pathway Flexibility in Nile Tilapia (<i>Oreochromis niloticus</i>). [PDF]

Animals (Basel)
Yan J, Wang X, Liu D, Song J, Liu S, Liu Q, Guo Z.   +6 more
europepmc   +1 more source

Peer Review #1 of "SLiM-Enrich: computational assessment of protein–protein interaction data as a source of domain-motif interactions (v0.1)"

, 2018
openaire   +3 more sources

CARMIL membrane-binding domain regulates capping protein and actin assembly. [PDF]

J Biol Chem
Mooren OL, McConnell P, DeBrecht JD, Cooper JA.   +3 more
europepmc   +1 more source

Genome-Wide Identification of the <i>JAZ</i> Gene Family in Garlic (<i>Allium sativum</i> L.) and the Functional Role of <i>AsJAZ17</i> in Salt Tolerance. [PDF]

Plants (Basel)
Cao Z, Li N.
europepmc   +1 more source

Molecular regulation of PGC-1α: from protein-protein interactions and post-translational modifications to pharmacological modulation. [PDF]

J Mol Med (Berl)
Rios WQ, Silva CM, Ferreira R, Gomes JRB.   +3 more
europepmc   +1 more source