Results 41 to 50 of about 543,220 (340)
Mapping protein–protein interactions by mass spectrometry
Mass Spectrometry ReviewsAbstractProtein–protein interactions (PPIs) are essential for numerous biological activities, including signal transduction, transcription control, and metabolism. They play a pivotal role in the organization and function of the proteome, and their perturbation is associated with various diseases, such as cancer, neurodegeneration, and infectious ...
Xiaonan Liu +4 more
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Diplomats or Defendants? Defining the Future of Head-of-State Immunity [PDF]
, 2002 Fluorescence nanoscopy provides means to discernthe finer details of protein localization and interaction in cells by offeringan order of magnitude higher resolution than conventional optical imagingtechniques.
Amelie Eriksson Karlström +6 more
core +3 more sources
Cost-Effective Mapping of Genetic Interactions in Mammalian Cells
Frontiers in Genetics, 2021 Comprehensive maps of genetic interactions in mammalian cells are daunting to construct because of the large number of potential interactions, ~ 2 × 108 for protein coding genes. We previously used co-inheritance of distant genes from published radiation
Arshad H. Khan, Desmond J. Smith
doaj +1 more source
Molecular Systems Biology, 2012 Protein and genetic interaction maps can reveal the overall physical and functional landscape of a biological system. To date, these interaction maps have typically been generated under a single condition, even though biological systems undergo ...
Trey Ideker, Nevan J Krogan
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Analytical results for stochastically growing networks: connection to the zero range process
, 2007 We introduce a stochastic model of growing networks where both, the number of new nodes which joins the network and the number of connections, vary stochastically.
P. Erdös, P. K. Mohanty, Sarika Jalan
core +1 more source
Lexical Adaptation of Link Grammar to the Biomedical Sublanguage: a Comparative Evaluation of Three Approaches [PDF]
, 2006 We study the adaptation of Link Grammar Parser to the biomedical sublanguage with a focus on domain terms not found in a general parser lexicon. Using two biomedical corpora, we implement and evaluate three approaches to addressing unknown words ...
Aubin, Sophie +3 more
core +4 more sources
Comparative mapping of host–pathogen protein–protein interactions [PDF]
Current Opinion in Microbiology, 2015 Pathogens usurp a variety of host pathways via protein-protein interactions to ensure efficient pathogen replication. Despite the existence of an impressive toolkit of systematic and unbiased approaches, we still lack a comprehensive list of these PPIs and an understanding of their functional implications.
Shah, Priya S +3 more
openaire +4 more sources
Nature Communications, 2016 The AAA+ ATPase p97 is an essential hexameric protein with multiple protein interaction partners and cellular functions. Here, the authors use interaction mapping to examine partner proteins of this large complex, and assess the effects of these proteins
Anup Arumughan +18 more
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Mapping the druggable allosteric space of G-protein coupled receptors: a fragment-based molecular dynamics approach. [PDF]
, 2010 To address the problem of specificity in G-protein coupled receptor (GPCR) drug discovery, there has been tremendous recent interest in allosteric drugs that bind at sites topographically distinct from the orthosteric site. Unfortunately, structure-based
Ivetac, Anthony, McCammon, J Andrew
core +2 more sources
Pooled‐matrix protein interaction screens using Barcode Fusion Genetics
Molecular Systems Biology, 2016 High‐throughput binary protein interaction mapping is continuing to extend our understanding of cellular function and disease mechanisms. However, we remain one or two orders of magnitude away from a complete interaction map for humans and other major ...
Nozomu Yachie +32 more
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