Results 41 to 50 of about 1,237,822 (372)
A Map of Interactions between the Proteins of a Retrotransposon [PDF]
Journal of Virology, 1998 ABSTRACTThe yeast two-hybrid system and in vitro binding assays were used to characterize 54 potential interactions between the proteins of Tf1, an LTR-retrotransposon found inSchizosaccharomyces pombe. The Tf1 integrase (IN) protein was found to interact strongly with itself and not with other control proteins.
Scott J. Steele, Henry L. Levin
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Frontiers in Genetics, 2021 Inflammatory bowel disease (IBD) is the common name for chronic disorders associated with the inflammation of the gastrointestinal tract. IBD is triggered by environmental factors in genetically susceptible individuals and has a significant number of ...
Sefika Feyza Maden, Saliha Ece Acuner
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Detecting Mutually Exclusive Interactions in Protein-Protein Interaction Maps
PLoS ONE, 2012 Comprehensive protein interaction maps can complement genetic and biochemical experiments and allow the formulation of new hypotheses to be tested in the system of interest. The computational analysis of the maps may help to focus on interesting cases and thereby to appropriately prioritize the validation experiments.
Carmen Sánchez Claros +3 more
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FEBS Open Bio, 2022 Over the past few decades, dozens of in vitro methods have been developed to map, investigate and validate protein–protein interactions. However, most of these approaches are time‐consuming and labour‐intensive or require specialised equipment or ...
Zsuzsánna Réthi‐Nagy +2 more
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Protein-protein interaction map for yeast TFIID [PDF]
Nucleic Acids Research, 2003 A major rate-limiting step in transcription initiation by RNA polymerase II is recognition and binding of the TATA element by the transcription factor TFIID. TFIID is composed of TATA binding protein (TBP) and approximately a dozen TBP-associated factors (TAFs).
Gayatri Yatherajam +3 more
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Identification of Breast Cancer Biomarkers by Constructing Protein-Protein Interaction and miRNAs-mRNAs Networks [PDF]
Middle East Journal of CancerBackground: In cancer-related diseases, early detection and control of disease progression are very important for successful treatment. Breast cancer is a significant problem due to its high mortality rate in the female population worldwide. By the early
Azizeh Asadzadeh +3 more
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Mapping Soluble Guanylyl Cyclase and Protein Disulfide Isomerase Regions of Interaction. [PDF]
PLoS ONE, 2015 Soluble guanylyl cyclase (sGC) is a heterodimeric nitric oxide (NO) receptor that produces cyclic GMP. This signaling mechanism is a key component in the cardiovascular system.
Erin J Heckler +5 more
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PathExpand: Extending biological pathways using molecular interaction networks [PDF]
, 2011 We present a methodology for extending pre-defined protein sets representing cellular pathways and processes by mapping them onto a protein-protein interaction network, and extending them to include densely interconnected interaction partners.
Alfonso Valencia +3 more
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CrY2H-seq: a massively multiplexed assay for deep-coverage interactome mapping. [PDF]
, 2017 Broad-scale protein-protein interaction mapping is a major challenge given the cost, time, and sensitivity constraints of existing technologies. Here, we present a massively multiplexed yeast two-hybrid method, CrY2H-seq, which uses a Cre recombinase ...
Bartlett, Anna +12 more
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Comparison of human protein–protein interaction maps [PDF]
Bioinformatics, 2007 AbstractMotivation: Large-scale mappings of protein–protein interactions have started to give us new views of the complex molecular mechanisms inside a cell. After initial projects to systematically map protein interactions in model organisms such as yeast, worm and fly, researchers have begun to focus on the mapping of the human interactome. To tackle
Hanspeter Herzel +2 more
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