Results 121 to 130 of about 6,367,317 (393)

Δ133p53α and Δ160p53α isoforms of the tumor suppressor protein p53 exert dominant-negative effect primarily by co-aggregation

eLife
p53 is a tumor suppressor protein with multiple isoforms with shared or specific functions. However, two of its isoforms, Δ133p53α and Δ160p53α, with large N-terminal deletions, can cause cancer.
Liuqun Zhao, Tanel Punga, Suparna Sanyal
doaj   +1 more source

C/EBPβ-1 promotes transformation and chemoresistance in Ewing sarcoma cells. [PDF]

, 2017
CEBPB copy number gain in Ewing sarcoma was previously shown to be associated with worse clinical outcome compared to tumors with normal CEBPB copy number, although the mechanism was not characterized.
Abegglen, Lisa M, Amatruda, James F, Carter, Bryce E, Gardiner, Jamie D, Huang, Xiaomeng, Kovar, Heinrich, Lessnick, Stephen L, Lor Randall, R, Paxton, Christian N, Putnam, Angelica R, Schackmann, Elizabeth A, Schiffman, Joshua D, Stucki, Marcus   +12 more
core   +1 more source

Tunable protein synthesis by transcript isoforms in human cells

bioRxiv, 2015
Eukaryotic genes generate multiple mRNA transcript isoforms though alternative transcription, splicing, and polyadenylation. However, the relationship between human transcript diversity and protein production is complex and not well understood at a ...
S. Floor, J. Doudna
semanticscholar   +1 more source

IsoSel: Protein Isoform Selector for phylogenetic reconstructions

PLOS ONE, 2017
The reliability of molecular phylogenies is strongly dependent on the quality of the assembled datasets. In the case of eukaryotes, the selection of only one protein isoform per genomic locus is mandatory to avoid biases linked to redundancy. Here, we present IsoSel, a tool devoted to the selection of alternative isoforms in the context of phylogenetic
Héloïse Philippon, Alexia Souvane, Céline Brochier-Armanet, Guy Perrière   +3 more
openaire   +4 more sources

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

The complex of TRIP-Br1 and XIAP ubiquitinates and degrades multiple adenylyl cyclase isoforms

eLife, 2017
Adenylyl cyclases (ACs) generate cAMP, a second messenger of utmost importance that regulates a vast array of biological processes in all kingdoms of life.
Wenbao Hu, Xiaojie Yu, Zhengzhao Liu, Ying Sun, Xibing Chen, Xin Yang, Xiaofen Li, Wai Kwan Lam, Yuanyuan Duan, Xu Cao, Hermann Steller, Kai Liu, Pingbo Huang   +12 more
doaj   +1 more source

Increasing myosin light chain 3f (MLC3f) protects against a decline in contractile velocity [PDF]

, 2019
Disuse induces adaptations in skeletal muscle, which lead to muscle deterioration. Hindlimb-unloading (HU) is a well-established model to investigate cellular mechanisms responsible for disuse-induced skeletal muscle dysfunction.
Asakura, Atsushi, Graber, Ted G., Kim, Jong-Hee, Liu, Haiming, Thompson, LaDora V.   +4 more
core   +2 more sources

p53 Family: Role of Protein Isoforms in Human Cancer

Journal of Nucleic Acids, 2011
TP53, TP63, and TP73 genes comprise the p53 family. Each gene produces protein isoforms through multiple mechanisms including extensive alternative mRNA splicing.
Jinxiong Wei, E. Zaika, A. Zaika
semanticscholar   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source