Results 161 to 170 of about 648,804 (352)

MED19 encodes two unique protein isoforms that confer prostate cancer growth under low androgen through distinct gene expression programs. [PDF]

Sci Rep, 2023
Ruoff R, Weber H, Wang Y, Huang H, Shapiro E, Fenyö D, Garabedian MJ.   +6 more
europepmc   +1 more source

Muscle lim protein isoform negatively regulates striated muscle actin dynamics and differentiation [PDF]

, 2014
Elizabeth Vafiadaki, Demetrios A. Arvanitis, Vasiliki Papalouka, Gerasimos Terzis, Theodoros I. Roumeliotis, Konstantinos Spengos, Spiros D. Garbis, Panagiota Manta, Evangelia G. Kranias, Despina Sanoudou   +9 more
openalex   +1 more source

Next‐Generation Bio‐Reducible Lipids Enable Enhanced Vaccine Efficacy in Malaria and Primate Models

Advanced Functional Materials, EarlyView.
Structure–activity relationship (SAR) optimization of bio‐reducible ionizable lipids enables the development of highly effective lipid nanoparticle (LNP) mRNA vaccines. Lead LNPs show superior tolerability and antibody responses in rodents and primates, outperforming approved COVID‐19 vaccine lipids.
Ruben De Coen, Sabah Kasmi, Shrinivas Dumbre, Lies Baekens, Elise Seynaeve, Louise Van den Hauwe, Niccolò Cantini, Aello Garantoudi, Filipe Branco Madeira, Alain Marrot, Emma Tuypens, Sofie Seghers, Anna Kuchmiy, Elisabeth Brabants, Bart Vanderborght, Ine Maes, Sarah Vandenberghe, Jessica Filtjens, Alícia Gordún Peiró, Daliya Kancheva, Ayla Debraekeleer, Florence Lambolez, Emily De Lombaerde, Yong Chen, Rafael Miyazawa Martins, Pauline Formaglio, Damya Laoui, Sofie Deschoemaeker, Bruno G. De Geest, Rogerio Amino, Stefaan De Koker   +30 more
wiley   +1 more source

The fixation of complement protein pairs to CR2 isoforms

Biochemistry and Biophysics Reports
Reviewing old protocols, it was found that Raji, a CR2-posistive cell line, binds both endogenous (e-C3) and exogenous C3 (i-C3). The processing of i-C3 to an i-C3b-like protein and their fixation to CR2 isoforms resulted in the formation of heterodimers whose units might be linked via thioester by low m.w. molecule(s).
openaire   +3 more sources

A 3D Biofabricated Disease Model Mimicking the Brain Extracellular Matrix Suitable to Characterize Intrinsic Neuronal Network Alterations in the Presence of a Breast Tumor Disseminated to the Brain

Advanced Functional Materials, EarlyView.
A 3D disease model is developed using customized hyaluronic‐acid‐based hydrogels supplemented with extracellular matrix (ECM) proteins resembling brain ECM properties. Neurons, astrocytes, and tumor cells are used to mimic the native brain surrounding.
Esra Türker, Mateo S. Andrade Mier, Jessica Faber, Mike Friedrich, Zan Lamberger, Jeannette Weigelt, Christian Stigloher, Nicoletta Murenu, Natascha Schaefer, Jörg Tessmar, Gregor Lang, Silvia Budday, Katrin G. Heinze, Antje Appelt‐Menzel, Pamela L. Strissel, Reiner Strick, Carmen Villmann   +16 more
wiley   +1 more source

Modelling eNvironment for Isoforms (MoNvIso): A general platform to predict structural determinants of protein isoforms in genetic diseases. [PDF]

Front Chem, 2022
Oliva F, Musiani F, Giorgetti A, De Rubeis S, Sorokina O, Armstrong DJ, Carloni P, Ruggerone P.   +7 more
europepmc   +1 more source

Myristoylation of cGMP-dependent Protein Kinase Dictates Isoform Specificity for Serotonin Transporter Regulation [PDF]

, 2010
Yuan‐Wei Zhang, Gary Rudnick
openalex   +1 more source

Peptide Sequencing With Single Acid Resolution Using a Sub‐Nanometer Diameter Pore

Advanced Functional Materials, EarlyView.
To sequence a single molecule of Aβ1−42–sodium dodecyl sulfate (SDS), the aggregate is forced through a sub‐nanopore 0.4 nm in diameter spanning a 4.0 nm thick membrane. The figure is a visual molecular dynamics (VMD) snapshot depicting the translocation of Aβ1−42–SDS through the pore; only the peptide, the SDS, the Na+ (yellow/green) and Cl− (cyan ...
Apurba Paul, Archith Rayabharam, Lisa Almonte, Eveline Rigo, Joshy Joseph, Ashutosh Kumar, Zhuxin Dong, Narayana Aluru, Gregory Timp   +8 more
wiley   +1 more source

Lyssavirus P Protein Isoforms Diverge Significantly in Subcellular Interactions Underlying Mechanisms of Interferon Antagonism. [PDF]

J Virol, 2022
Brice AM, Rozario AM, Rawlinson SM, David CT, Wiltzer-Bach L, Jans DA, Ito N, Bell TDM, Moseley GW.   +8 more
europepmc   +1 more source

A ratiometric catalog of protein isoform shifts in the cardiac fetal gene program [PDF]

Yu Han, Shaonil Binti, Sara A. Wennersten, Boomathi Pandi, Dominic C. M. Ng, Edward Lau, Maggie P. Y. Lam   +6 more
openalex   +1 more source