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Interactions and conversions of prion protein isoforms
2001Publisher Summary The properties of amyloidogenic protease-resistant form (PrP-res) have failed attempts to determine its high resolution structure. Nonetheless, low resolution analyses have shown that PrP-res retains significant α-helical content, but has much higher β-sheet content than PrP C .
Cai'ne Wong +5 more
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Signalling by protein kinase C isoforms in the heart
Molecular and Cellular Biochemistry, 1996Understanding transmembrane signalling process is one of the major challenge of the decade. In most tissues, since Fisher and Krebs's discovery in the 1950's, protein phosphorylation has been widely recognized as a key event of this cellular function.
Michel Pucéat, Guy Vassort
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Contractile protein isoforms in muscle development
Developmental Biology, 1992The contractile proteins of skeletal muscle are often represented by families of very similar isoforms. Protein isoforms can result from the differential expression of multigene families or from multiple transcripts from a single gene via alternative splicing.
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The immunodetection of the abnormal isoform of prion protein. [PDF]
The Histochemical journal, 1999 Transmissible spongiform encephalopathies such as scrapie in sheep and goats, Creutzfeldt-Jakob disease in humans and bovine spongiform encephalopathy in cattle, are neurodegenerative disorders. A proposed causative agent for these diseases is an infectious protein, the so called 'prion'.
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1987
All active cell movement originates in the interaction of only a few different classes of protein molecules. The major representatives are Actin and Tropomyosin, which can assemble into long and thin filamentous polymers, and Myosin, which can also aggregate to form thick filaments.
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All active cell movement originates in the interaction of only a few different classes of protein molecules. The major representatives are Actin and Tropomyosin, which can assemble into long and thin filamentous polymers, and Myosin, which can also aggregate to form thick filaments.
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Protein kinase C isoforms in human erythrocytes
Annals of Hematology, 2001Erythrocytes are the most abundant cells in blood and carry out the vital function of oxygen transport. These cells lack nuclei and do not synthesise new proteins. Their cellular responses are modulated entirely by post-translational modifications in existing proteins.
Govekar Rb, Zingde Sm
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Allergenicity of some isoforms of white sesame proteins
Clinical & Experimental Allergy, 2002SummaryBackground Allergy to sesame seeds is often associated with particularly severe reactions, with a high risk of anaphylaxis. The increase in reports of allergic reactions to sesame is probably due to the growing use of sesame seeds or sesame oil in food.Objective To determine the molecular weights of the proteins in three variety of sesame seeds ...
N. Zitouni +6 more
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Isoform separation of proteins by mixed-mode chromatography
Protein Expression and Purification, 2015Mixed-mode chromatography uses a multimodal functional resin, mainly composed of electrostatic and aromatic/hydrophobic groups. Here we have tested 2 mixed-mode resins, anion-exchange Capto adhere and cation-exchange Capto MMC, using 2 model proteins, i.e., an Fc-fusion etanercept, and bovine serum albumin (BSA). When etanercept was produced in Chinese
Glen Young, Tsutomu Arakawa, Sean Ponce
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Absolute Quantitation of Protein Posttranslational Modification Isoform
2015Mass spectrometry has been widely applied in characterization and quantification of proteins from complex biological samples. Because the numbers of absolute amounts of proteins are needed in construction of mathematical models for molecular systems of various biological phenotypes and phenomena, a number of quantitative proteomic methods have been ...
Yang, Zhu, Li, Ning
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Prediction of novel isoforms of the mouse Mpv17l protein
Genome, 2009The Mpv17l protein has two isoforms, M-LPL and M-LPS, which both regulate the production of reactive oxygen species (ROS) and protect against mitochondrial oxidative stress and apoptosis. M-LPL is ubiquitously expressed, while M-LPS is expressed mostly in the kidney of aged animals.
Luis Lopez de Heredia +2 more
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