Results 71 to 80 of about 6,367,317 (393)

The slow sarco/endoplasmic reticulum Ca2+-ATPase declines independently of slow myosin in soleus muscle of diabetic rats [PDF]

, 2009
The sarcoplasmic reticulum Ca2+-ATPase (SERCA) isoforms are normally expressed in coordination with the corresponding myosin heavy chain (MyHC) isoforms in the fibers of skeletal muscle but this coordination is often disrupted in pathological conditions.
Rácz, Gábor, Szabó, András, Vér, Ágota, Zádor, Ernő   +3 more
core  

A novel human glucocorticoid receptor SNP results in increased transactivation potential. [PDF]

, 2017
Glucocorticoids are one of the most widely used therapeutics in the treatment of a variety of inflammatory disorders. However, it is known that there are variable patient responses to glucocorticoid treatment; there are responders and non-responders, or ...
Cho, Kiho, Green, Tajia L, Greenhalgh, David G, Leventhal, Stacey M, Lim, Debora, Tung, Kelly   +5 more
core   +3 more sources

Detecting p53 Isoforms at Protein Level

, 2012
The human p53 protein isoforms are expressed in several cell lines and modulate p53 tumor suppressor -activity, mainly through modulation of gene expression (1-4). Thus, identifying the pattern of p53 isoforms expression in cell lines is a key step for future studies of the p53 network (5).
Marcel, Virginie, Khoury, Marie, Fernandes, Kenneth, Diot, Alexandra, Lane, David, Bourdon, Jean-Christophe   +5 more
openaire   +3 more sources

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Targeted mutagenesis of the Sap47 gene of Drosophila: Flies lacking the synapse associated protein of 47 kDa are viable and fertile [PDF]

, 2004
BACKGROUND: Conserved proteins preferentially expressed in synaptic terminals of the nervous system are likely to play a significant role in brain function.
Becker, Sonja, Brunner, Marion, Buchner, Erich, Funk, Natalja, Huber, Saskia   +4 more
core   +3 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Down‐regulation of wheat Rubisco activase isoforms expression by virus‐induced gene silencing

Plant Direct
Rubisco activase (Rca) is an essential photosynthetic enzyme that removes inhibitors from the catalytic sites of the carboxylating enzyme Rubisco. In wheat, Rca is composed of one longer 46 kDa α‐isoform and two shorter 42 kDa β‐isoforms encoded by the ...
Juan Alejandro Perdomo, Joanna C. Scales, Wing‐Sham Lee, Kostya Kanyuka, Elizabete Carmo‐Silva   +4 more
doaj   +1 more source

PHLPP isoforms differentially regulate Akt isoforms and AS160 affecting neuronal insulin signaling and insulin resistance via Scribble

Cell Communication and Signaling, 2022
Background The aim of the present study was to determine the role of individual PHLPP isoforms in insulin signaling and insulin resistance in neuronal cells.
Medha Sharma, Chinmoy Sankar Dey
doaj   +1 more source

Improving Genome-Wide Scans of Positive Selection by Using Protein Isoforms of Similar Length

Genome Biology and Evolution, 2013
Large-scale evolutionary studies often require the automated construction of alignments of a large number of homologous gene families. The majority of eukaryotic genes can produce different transcripts due to alternative splicing or transcription ...
J. Villanueva-Cañas, S. Laurie, M. Albà, M. Albà   +3 more
semanticscholar   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source