Results 71 to 80 of about 242,506 (191)

PIP5KIβ Selectively Modulates Apical Endocytosis in Polarized Renal Epithelial Cells [PDF]

, 2013
Localized synthesis of phosphatidylinositol 4,5-bisphosphate [PtdIns(4,5)P2] at clathrin coated pits (CCPs) is crucial for the recruitment of adaptors and other components of the internalization machinery, as well as for regulating actin dynamics during ...
A Benmerah, A Gassama-Diagne, A Le Bivic, A Oztan, AL Rozelle, AV Oleinikov, BA Potter, BM Collins, Brianne E. Docter, Christina M. Szalinski, Christopher J. Guerriero, CJ Guerriero, CJ Maples, CJ Merrifield, CJ Merrifield, CN Antonescu, D Padron, DJ James, DK Strickland, F Gong, F Martin-Belmonte, F Martin-Belmonte, G Apodaca, G Apodaca, G Di Paolo, G Di Paolo, G Rohde, G Spudich, G Spudich, Gerard Apodaca, H Ishihara, H Ishihara, HY Naim, HY Naim, I van den Bout, J Hyman, J Zheng, JC Loijens, JM Anderson, Joshua Z. Rappoport, JR Henkel, JZ Rappoport, KM Vasudevan, KM Weixel, L Fang, LA Volpicelli-Daley, LA Volpicelli-Daley, LM Traub, M Bens, M Jost, M Krauss, M Nagai, MA Barbieri, MA Lemmon, MA Lokuta, MA Puthenveedu, Manojkumar A. Puthenveedu, MG Ford, Núria M. Pastor-Soler, O Cremona, O Idevall-Hagren, Ora A. Weisz, P Khandelwal, P Varnai, PC Stolt, PP Breitfeld, R Rohatgi, R Rohatgi, R Rojas, R Rojas, R Zoncu, RV Stahelin, RW Holz, S Benesch, S Boulant, S Cui, S Hardy, S Mukherjee, SF Bairstow, SJ Mundell, SK Mishra, T Hyman, T Itoh, TA Gottlieb, V Haucke, Wily G. Ruiz, Y Aikawa, Y Wang, Youssef Rbaibi, YS Mao   +89 more
core   +3 more sources

Long non‐coding RNAs as therapeutic targets in head and neck squamous cell carcinoma and clinical application

FEBS Open Bio, EarlyView.
Long non‐coding RNAs (lncRNAs) occupy an abundant fraction of the eukaryotic transcriptome and an emerging area in cancer research. Regulation by lncRNAs is based on their subcellular localization in HNSCC. This cartoon shows the various functions of lncRNAs in HNSCC discussed in this review.
Ellen T. Tran, Ruchi A. Patel, Amogh Chariyamane, Ratna B. Ray   +3 more
wiley   +1 more source

OPA1 processing controls mitochondrial fusion and is regulated by mRNA splicing, membrane potential, and Yme1L [PDF]

, 2007
OPA1, a dynamin-related guanosine triphosphatase mutated in dominant optic atrophy, is required for the fusion of mitochondria. Proteolytic cleavage by the mitochondrial processing peptidase generates long isoforms from eight messenger RNA (mRNA) splice ...
Alexander, Christiane, Chan, David C., Chen, Hsiuchen, Fiket, Maja, Song, Zhiyin   +4 more
core   +3 more sources

Neurotoxic amyloid β‐peptide and tau produce cytokine‐like effects on PMCA in glioblastoma cell lines, enhancing its activity and isoforms expression

FEBS Open Bio, EarlyView.
Two biomarkers of Alzheimer's disease, amyloid β‐peptide (Aβ) and tau, induce the transformation of U‐251 and other glioblastoma cell lines into neurotoxic A1‐like reactive astrocytes. This transformation is produced by cytokines and is followed by upregulation of PMCA activity and isoform expression, and is closely associated with inflammation, as ...
María Berrocal, Alberto Alvarez‐Barrientos, Ana M. Mata   +2 more
wiley   +1 more source

Iron‐dependent lysosomal LDL oxidation induces the expression of scavenger receptor A in human THP‐1 monocytes

FEBS Open Bio, EarlyView.
In human monocytic cells THP‐1, a limited uptake of native—not oxidized—LDL/VLDL induced expression of scavenger receptor A and cellular adhesion. Induction was inhibited by lysosomotropic (WR‐1065) and lipophilic (BHT) antioxidants and by siRNAs against ferritinophagy.
Martina Čierna, Richard Buchal, Martin Leníček, Amit Shachak, Jan Pláteník   +4 more
wiley   +1 more source

A novel protein isoform of the RON tyrosine kinase receptor transforms human pancreatic duct epithelial cells. [PDF]

, 2016
The MST1R gene is overexpressed in pancreatic cancer producing elevated levels of the RON tyrosine kinase receptor protein. While mutations in MST1R are rare, alternative splice variants have been previously reported in epithelial cancers.
Babicky, M, Chakedis, J, French, R, Holman, P, Howard, H, Jaquish, D, Lam, R, Lowy, AM, Miyamoto, J, Mose, E, Walterscheid, Z   +10 more
core   +2 more sources

The impact of frailty syndrome on skeletal muscle histology: preventive effects of exercise

FEBS Open Bio, EarlyView.
Frailty syndrome exacerbates skeletal muscle degeneration via increased ECM deposition and myofiber loss. This study, using a murine model, demonstrates that endurance exercise attenuates these histopathological alterations, preserving muscle integrity. Findings support exercise as a viable strategy to counteract frailty‐induced musculoskeletal decline
Fujue Ji, Hae Sung Lee, Haesung Lee, Jong‐Hee Kim   +3 more
wiley   +1 more source

Influence of Temperature, Hypercapnia, and Development on the Relative Expression of Different Hemocyanin Isoforms in the Common Cuttlefish Sepia officinalis [PDF]

, 2012
The cuttlefish Sepia officinalis expresses several hemocyanin isoforms with potentially different pH optima, indicating their reliance on efficient pH regulation in the blood.
Gutowska, Magdalena A., Hu, Marian Y.A., Lieb, Bernhard, Lucassen, Magnus, Mark, Felix Christopher, Melzner, Frank, Pörtner, Hans-Otto, Strobel, Anneli   +7 more
core   +1 more source

The role of circular RNAs in regulating cytokine signaling in cancer

FEBS Open Bio, EarlyView.
Cytokines present in the tumor microenvironment fuel cancer development. Aberrant expression of circRNAs contributes to cancer progression. Cytokines are involved in regulating circRNA biogenesis. Furthermore, aberrantly expressed circRNAs regulate the expression of ligands, receptors, and downstream effectors involved in cytokine signaling to promote ...
Vandana Joshi, Swati, Amit Mishra, Amaresh Panda, Vivek Sharma   +4 more
wiley   +1 more source

Galpha 12 and Galpha 13 Are Phosphorylated during Platelet Activation [PDF]

, 1996
The ubiquitously expressed G-proteins G12 and G13 whose function is currently not clear have been shown to be activated in platelet membranes through receptors that stimulate platelet aggregation. We used intact human platelets to determine whether alpha
Hu, Yi-Hui, Offmanns, Stefan, Simon, Melvin I.   +2 more
core