Results 81 to 90 of about 648,804 (352)

Smoking increases expression of the SARS-CoV-2 spike protein-binding long ACE2 isoform in bronchial epithelium [PDF]

, 2023
Simon D. Pouwels, Maarten van den Berge, Gwenda F. Vasse, Wim Timens, Corry‐Anke Brandsma, Hananeh Aliee, Pieter S. Hiemstra, Victor Guryev, Alen Faiz   +8 more
openalex   +1 more source

C/EBPβ-1 promotes transformation and chemoresistance in Ewing sarcoma cells. [PDF]

, 2017
CEBPB copy number gain in Ewing sarcoma was previously shown to be associated with worse clinical outcome compared to tumors with normal CEBPB copy number, although the mechanism was not characterized.
Abegglen, Lisa M, Amatruda, James F, Carter, Bryce E, Gardiner, Jamie D, Huang, Xiaomeng, Kovar, Heinrich, Lessnick, Stephen L, Lor Randall, R, Paxton, Christian N, Putnam, Angelica R, Schackmann, Elizabeth A, Schiffman, Joshua D, Stucki, Marcus   +12 more
core   +1 more source

Integration of circadian and hypoxia signaling via non‐canonical heterodimerization

FEBS Letters, EarlyView.
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley   +1 more source

Inhibitory effect of truncated isoforms on GPCR dimerization predicted by combinatorial computational strategy

Computational and Structural Biotechnology Journal
G protein-coupled receptors (GPCRs) play a pivotal role in fundamental biological processes and disease development. GPCR isoforms, derived from alternative splicing, can exhibit distinct signaling patterns.
Mengke Li, Rui Qing, Fei Tao, Ping Xu, Shuguang Zhang   +4 more
doaj   +1 more source

The TRIOBP Isoforms and Their Distinct Roles in Actin Stabilization, Deafness, Mental Illness, and Cancer

Molecules, 2020
The TRIOBP (TRIO and F-actin Binding Protein) gene encodes multiple proteins, which together play crucial roles in modulating the assembly of the actin cytoskeleton.
Beti Zaharija, Bobana Samardžija, Nicholas J. Bradshaw   +2 more
doaj   +1 more source

Genome-wide analysis of the UDP-glucose dehydrogenase gene family in Arabidopsis, a key enzyme for matrix polysaccharides in cell walls [PDF]

, 2007
Arabidopsis cell walls contain large amounts of pectins and hemicelluloses, which are predominantly synthesized via the common precursor UDP-glucuronic acid.
Klinghammer, Michaela, Tenhaken, Raimund
core   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Cardiac Actions of Protein Kinase C Isoforms [PDF]

Physiology, 2012
Protein kinase C (PKC) isoforms have emerged as important regulators of cardiac contraction, hypertrophy, and signaling pathways that influence ischemic/reperfusion injury. This review focuses on newer concepts regarding PKC isoform-specific activation mechanisms and actions that have implications for the development of PKC-targeted therapeutics.
openaire   +2 more sources

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Marshalin, a microtubule minus-end binding protein, regulates cytoskeletal structure in the organ of Corti

Biology Open, 2013
Summary Dramatic structural changes in microtubules (MT) and the assembly of complicated intercellular connections are seen during the development of the cellular matrix of the sense organ for hearing, the organ of Corti.
Jing Zheng, David Furness, Chongwen Duan, Katharine K. Miller, Roxanne M. Edge, Jessie Chen, Kazuaki Homma, Carole M. Hackney, Peter Dallos, Mary Ann Cheatham   +9 more
doaj   +1 more source