Results 81 to 90 of about 242,506 (191)

Alternative translation initiation in rat brain yields K2P2.1 potassium channels permeable to sodium. [PDF]

, 2008
K(2P) channels mediate potassium background currents essential to central nervous system function, controlling excitability by stabilizing membrane potential below firing threshold and expediting repolarization. Here, we show that alternative translation
Goldstein, Steve AN, McCrossan, Zoe A, Plant, Leigh D, Thomas, Dierk, Wilkens, Christina M   +4 more
core   +1 more source

Synaptic Vesicle Protein 2 (SV2) Isoforms

Asian Pacific Journal of Cancer Prevention, 2012
New molecular markers of cancer had emerged with novel applications in cancer prevention and therapeutics, including for breast cancer of unknown causes, which has a high impact on the health of women worldwide. The purpose of this research was to determine protein and mRNA expression of synaptic vesicle 2 (SV2) isoforms A, B and C in breast cancer ...
S. Juarez-Mendez, C.I. Bazan-Mendez, Cindy Bandala, Ángel Miliar-García, Eleazar Lara-Padilla, César M. Mejía-Barradas, Juan Pedro Luna-Arias, M. Anaya-Ruiz, Modesto Gómez-López   +8 more
openaire   +4 more sources

Electric Pulse Regulated MXene Based Nanozymes for Integrative Bioelectricity Immuno‐Cancer Therapy

Advanced Functional Materials, EarlyView.
MXenzyme‐mediated bioelectricity cancer therapy (MXenzyme‐BECT) enhances cancer cell death through irreversible depolarization, ion channel disruption, ROS generation, and immunogenic cell death. Computational simulations reveal the electrical mechanisms by which MXenzyme acts on single cells and support to predict treatment parameters. Next‐generation
Sanghee Lee, Seongchan Kim, Eui‐Sang Yu, Sian Lee, Min Jun Ko, Hyojin Lee, Dong‐Hyun Kim   +6 more
wiley   +1 more source

Multiple SecA protein isoforms in Escherichia coli [PDF]

Journal of Bacteriology, 1987
To define the anti-SecA-LacZ antiserum, immunoprecipitates produced with either whole anti-SecA-LacZ rabbit antiserum or affinity-purified antibodies were used to analyze nondenatured lysates of Escherichia coli. The antiserum contains antibodies that recognize different proteins.
openaire   +3 more sources

Flow‐Induced Vascular Remodeling on‐Chip: Implications for Anti‐VEGF Therapy

Advanced Functional Materials, EarlyView.
Flow‐induced vascular remodeling plays a critical role in network stabilization and function. Using a vasculature‐on‐chip system, this study reveals how physiological VEGF levels and flow affect vascular remodeling and provides insights into tumor vessel normalization.
Fatemeh Mirzapour‐Shafiyi, Elias Huber, Leonie Karr, Johnny Tong, Andreas Richard Bausch, Friedrich Christian Simmel, Karen Alim   +6 more
wiley   +1 more source

Utilizing RNA-Seq Data for Cancer Network Inference

, 2012
An important challenge in cancer systems biology is to uncover the complex network of interactions between genes (tumor suppressor genes and oncogenes) implicated in cancer. Next generation sequencing provides unparalleled ability to probe the expression
Atwal, Gurinder S., Cai, Ying, Fendler, Bernard   +2 more
core   +1 more source

Synthetic Strategy for mRNA Encapsulation and Gene Delivery with Nanoscale Metal‐Organic Frameworks

Advanced Functional Materials, EarlyView.
This research utilizes the ZIF‐8 for the encapsulation and intracellular delivery of nucleic acids, specifically mRNA, for applications in gene delivery. Integrating PEI addresses the issue of mRNA leakage from ZIF‐8, resulting in the delivery and expression of green fluorescent protein (GFP) in vitro and firefly luciferase in vivo.
Harrison Douglas Lawson, Huy Hoang Nguyen, Keng‐Jung Lee, Nattarat Wongsuwan, Ayesha Tupe, Mengrou Lu, Mariah Lynn Arral, Anne Behre, Zihan Ling, Kathryn Ann Whitehead, Adam Walter Feinberg, Xi Ren, Si‐Yang Zheng   +12 more
wiley   +1 more source

14-3-3 proteins. a highly conserved, widespread family of eukaryotic proteins [PDF]

, 1992
A family of proteins known as 14-3-3 is currently receiving increased attention by investigators studying a broad range of biological systems, including plants and invertebrates. The outstanding feature of this family is the extraordinarily high sequence
Aitken, Boston, Brandt, Bustos, Campbell, Celis, Celis, Hirsch, Ichimura, Ichimura, Ichimura, Isobe, Martens, Mochly-Rosen, Moore, Morgan, Nielsen, Parker, Pearson, Pepinsky, Rosenboom, Rosenfeld, Schejter, Schlaepfer, Swanson, Toker, Toker, van Heusden, Watanabe, Zupan   +29 more
core   +1 more source

Engineering Assembloids to Mimic Graft‐Host Skeletal Muscle Interaction

Advanced Healthcare Materials, EarlyView.
This study develops a graft‐host skeletal muscle assembloid model combining neuromuscular organoids with tissue‐engineered constructs. Pre‐seeding decellularized muscles with myogenic cells enhances cell migration and axon invasion from the organoid. The model exhibits regenerative capacity following acute damage, advancing the understanding of human ...
Lucia Rossi, Beatrice Auletta, Luigi Sartore, Marco La Placa, Giada Cecconi, Pietro Chiolerio, Edoardo Maghin, Silvia Angiolillo, Eugenia Carraro, Onelia Gagliano, Cecilia Laterza, Nicola Elvassore, Martina Piccoli, Anna Urciuolo   +13 more
wiley   +1 more source

A novel human glucocorticoid receptor SNP results in increased transactivation potential. [PDF]

, 2017
Glucocorticoids are one of the most widely used therapeutics in the treatment of a variety of inflammatory disorders. However, it is known that there are variable patient responses to glucocorticoid treatment; there are responders and non-responders, or ...
Cho, Kiho, Green, Tajia L, Greenhalgh, David G, Leventhal, Stacey M, Lim, Debora, Tung, Kelly   +5 more
core   +3 more sources