Results 291 to 300 of about 87,731 (343)

Demonstration of beat‐to‐beat, on‐demand ATP synthesis in ventricular myocytes reveals sex‐specific mitochondrial and cytosolic dynamics

The Journal of Physiology, EarlyView.
Abstract figure legend Beat‐locked mitochondrial ATP transients reveal modular, sex‐specific bioenergetic control during excitation–contraction coupling. A, each action potential activates L‐type CaV1.2 channels, producing a Ca2+ influx that triggers ryanodine receptors (RyR2) and elicits SR Ca2+ release.
Paula Rhana, Collin Matsumoto, L. Fernando Santana   +2 more
wiley   +1 more source

MAPK Signaling Pathway May Directly Regulate the Expression of Hydrophobin Genes in <i>Flammulina filiformis</i>. [PDF]

J Fungi (Basel)
Huang Q, Tong Z, Guan X, Qiao Q, Liu S, Zhang W, Wei Q, Xie B.   +7 more
europepmc   +1 more source

Targeted disruption of the RI and RII regulatory subunits of the cAMP-dependent protein kinase (PKA) in mice: physiological and neurobiological defects

, 1996
Eugene P. Brandon
openalex   +1 more source

Human‐derived cardiac‐neural microtissues reveal catecholaminergic polymorphic ventricular tachycardia is also a disease of the sympathetic neuron

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic diagram illustrating the proposed pathway in which regulatory defects might occur in sympathetic neurons derived from hiPSC in catecholaminergic polymorphic ventricular tachycardia (CPVT). Specifically, enhanced calcium transients appeared to derive from three sources: enhanced membrane excitability (due to loss of ...
Ni Li, Chenchen Zhang, Mengying Xu, YoonYoung Choi, Davi Sidarta‐Oliveira, Ruirui Dong, Xinyu Hu, Enrique M. Toledo, Cesar A. Prada‐Medina, Finbar Argus, Kun Liu, Mingyu Li, Linna Zhou, Hagan Bayley, Corey Smith, Chris Denning, Ana I. Domingos, Guoliang Hao, Dan Li, David J. Paterson   +19 more
wiley   +1 more source

MYCN inhibits TrkC-mediated differentiation in neuroblastoma cells via disruption of the PKA signalling pathway. [PDF]

Cell Death Discov
Maher S, Roe A, Wynne K, Zhernovkov V, Halasz M.   +4 more
europepmc   +1 more source

Translating cardiovascular ion channel and Ca2+ signalling mechanisms into therapeutic insights

The Journal of Physiology, EarlyView.
Abstract figure legend This white paper integrates mechanistic discoveries across ion channel biology, Ca2+ signalling and multiscale cardiovascular physiology to highlight new opportunities for accelerating research and guiding next‐generation therapies. Printed with permission from ®Anita Impagliazzo Medical Illustration. [Correction added on 2 March
Silvia Marchianò, Miguel Martín‐Aragón Baudel, Charlotte E. R. Smith, Gonzalo Hernandez Hernandez, Donald M. Bers, Patrick M. Boyle, Dobromir Dobrev, Shanna Hamilton, Osama F. Harraz, Na Li, Thomas A. Longden, William E. Louch, Madeline Nieves‐Cintron, Matthew A. Nystoriak, Walter Lee Murfee, Przemysław B. Radwański, Swapnil K. Sonkusare, Manuel F. Navedo, Eleonora Grandi   +18 more
wiley   +1 more source

Biophysical and aerodynamic properties of a peptide targeting the A-kinase anchoring function of PI3Kγ for pulmonary cAMP modulation. [PDF]

Sci Rep
Della Sala A, Sala V, Butnarasu CS, Tasca L, Costabile G, Mergiotti M, Gramegna A, Blasi F, Aliberti S, Ungaro F, Visentin S, Hirsch E, Ghigo A.   +12 more
europepmc   +1 more source

Medium Composition Determines the Dynamics of Boar In Vitro Sperm Capacitation-Associated Events. [PDF]

Int J Mol Sci
Klusackova B, Pilsova Z, Bryndova B, Pilsova A, Zelenkova N, Pecina P, Knezu M, Secova P, Tymich Hegrova P, Chmelikova E, Komrskova K, Simonik O, Postlerova P.   +12 more
europepmc   +1 more source

Dopamine D2 Receptors, D1/D2 Receptor Heteromers and CaMKII Signaling in the Neurobiology of Drug Addiction. [PDF]

Mol Neurobiol
Jia W, He X, Cheng A, He Y, Zhao F, Fukunaga K, Zhao W.   +6 more
europepmc   +1 more source

CaSR regulates SLC26A6 expression via the PKA-FOXO4 signaling axis to promote experimental calcium oxalate kidney stone formation in rats. [PDF]

Front Cell Dev Biol
Gan L, Li W, Luo P, Zhang F, Zhong H, Xie M, Lu Y, Qian B, Zheng L.   +8 more
europepmc   +1 more source