Results 301 to 310 of about 87,731 (343)

cAMP links PI3K to multiple signaling pathways

, 2007
Cosentino, Claudia
core  

The expanding landscape of the glucagon signaling network: mechanisms and outcomes.

Endocrinology
Foollee A, Wu Y, Rusu PM, Rose AJ.
europepmc   +1 more source

Context-Dependent Control: PKA Regulation of Vascular Ca_V1.2 Requires S1928 not Rad Phosphorylation. [PDF]

Arterioscler Thromb Vasc Biol
Voorhees HM, Taylor JL, Westhoff M, Hell JW, Dixon RE, Nieves-Cintrón M, Martín-Aragón Baudel M, Navedo MF.   +7 more
europepmc   +1 more source

Pathogenesis of nonfamilial somatotroph adenomas.

J Clin Endocrinol Metab
Ben-Shlomo A, Melmed S.
europepmc   +1 more source

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PKA: a portrait of protein kinase dynamics

Biochimica Et Biophysica Acta - Proteins and Proteomics, 2004
Protein kinases play a critical role in the integration of signaling networks in eukaryotic cells. cAMP-dependent protein kinase (PKA) serves as a prototype for this large and highly diverse enzyme family. The catalytic subunit of PKA provides the best example of how a protein kinase recognizes its substrates, as well as inhibitors, and also show how ...
Susan S Taylor, Elżbieta Radzio-Andzelm   +1 more
exaly   +3 more sources

Analysis of A-kinase anchoring protein (AKAP) interaction with protein kinase A (PKA) regulatory subunits: PKA isoform specificity in AKAP binding

Journal of Molecular Biology, 2000
Compartmentalization of cAMP-dependent protein kinase (PKA) is in part mediated by specialized protein motifs in the dimerization domain of the regulatory (R)-subunits of PKA that participate in protein-protein interactions with an amphipathic helix region in A-kinase anchoring proteins (AKAPs).
Friedrich W Herberg, Kjetil Taskén
exaly   +3 more sources

Protein Implicated in Nonsyndromic Mental Retardation Regulates Protein Kinase A (PKA) Activity [PDF]

Journal of Biological Chemistry, 2012
Mutation of the coiled-coil and C2 domain-containing 1A (CC2D1A) gene, which encodes a C2 domain and DM14 domain-containing protein, has been linked to severe autosomal recessive nonsyndromic mental retardation. Using a mouse model that produces a truncated form of CC2D1A that lacks the C2 domain and three of the four DM14 domains, we show that CC2D1A ...
Sung Yun Jung, Dou Liu, Bing Su
exaly   +4 more sources

Catalytic Subunit of PKA as a Prototype of the Eukaryotic Protein Kinase Family

Biochemistry (Moscow), 2020
The catalytic subunit of protein kinase A (PKAc) is conserved in all eukaryotic protein kinases. PKAc consists of two lobes that form the catalytic cleft containing the ATP-binding, peptide-binding site, and catalytic sites. During folding, PKAc secondary structures organize so that the non-polar regions form a globular core, while mobile loops and ...
B A, Reikhardt, P D, Shabanov
openaire   +2 more sources