Results 311 to 320 of about 87,731 (343)

cAMP-Dependent Protein Kinase A (PKA)–Mediated c-Myc Degradation Is Dependent on the Relative Proportion of PKA-I and PKA-II Isozymes

Molecular Pharmacology, 2015
The transcription factor c-Myc regulates numerous target genes that are important for multiple cellular processes such as cell growth and differentiation. It is commonly deregulated in leukemia. Acute promyelocytic leukemia (APL) is characterized by a blockade of granulocytic differentiation at the promyelocyte stage.
Qingyuan, Liu, Eric, Nguyen, Stein, Døskeland, Évelyne, Ségal-Bendirdjian   +3 more
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Interaction of gdt1 and protein kinase A (PKA) in the growth-differentiation-transition in Dictyostelium

Differentiation, 2001
The gdt1 gene is a negative regulator of the growth-differentiation-transition (GDT) in Dictyostelium. gdt1- cells express the GDT marker discoidin earlier and at higher levels and prematurely enter the differentiation pathway. Protein kinase A is a positive regulator of the GDT and is required for multicellular development.
C, Zeng, C, Anjard, G, Primpke, B, Wetterauer, S, Wille, W, Nellen   +5 more
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Inhibitors of PKA and Related Protein Kinases

2005
The AGC group of protein kinases comprises a number of pharmacologically important members—targets for small molecule inhibitors of therapeutic value. Crystal structure data assist in the design of new or improved inhibitory molecules. Protein kinase A (PKA), one of the longest and best-known members of the AGC kinase group, has been cocrystallized ...
M. Gaßel, C. Breitenlechner, S. Herrero, R. Engh, D. Bossemeyer   +4 more
openaire   +1 more source

PKA Cβ: a forgotten catalytic subunit of cAMP-dependent protein kinase opens new windows for PKA signaling and disease pathologies

Biochemical Journal, 2021
3′,5′-cyclic adenosine monophosphate (cAMP) dependent protein kinase or protein kinase A (PKA) has served as a prototype for the large family of protein kinases that are crucially important for signal transduction in eukaryotic cells. The PKA catalytic subunits are encoded by the two major genes PRKACA and PRKACB, respectively.
Susan S. Taylor, Maximilian Wallbott, Erik M. F. Machal, Kristoffer Søberg, Faihaa Ahmed, Jessica Bruystens, Lily Vu, Blaine Baker, Jian Wu, Francesco Raimondi, Elimelda M. Ongeri, Friedrich W. Herberg, Bjørn S. Skålhegg   +12 more
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Crystallography for protein kinase drug design: PKA and SRC case studies

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2005
Protein crystallography can be used throughout the drug discovery process to obtain diverse information critical for structure based drug design. At a minimum, a single target structure may be available. Optimally, and especially for protein kinases, a broad range of crystal structures should be obtained to characterize target flexibility, structure ...
Christine B, Breitenlechner, Dirk, Bossemeyer, Richard A, Engh   +2 more
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Periodic Signaling Controlled by an Oscillatory Circuit That Includes Protein Kinases ERK2 and PKA

Science, 2004
Self-regulating systems often use robust oscillatory circuits. One such system controls the chemotactic signaling mechanism of Dictyostelium , where pulses of adenosine 3′,5′-monophosphate (cAMP) are generated with a periodicity of 7 minutes.
Mineko, Maeda, Sijie, Lu, Gad, Shaulsky, Yuji, Miyazaki, Hidekazu, Kuwayama, Yoshimasa, Tanaka, Adam, Kuspa, William F, Loomis   +7 more
openaire   +2 more sources

Protein Kinase A (PKA) - A Potential Target for Therapeutic Intervention of Dysfunctional Immune Cells

Current Drug Targets, 2005
In several cases of immunodeficiency and autoimmunity, the dysfunctional immune system is associated with either hypo- or hyperactive T and B cells. In autoimmune conditions such as systemic lupus erythematosus (SLE) and immunodeficiencies such as acquired immunodeficiency syndrome (AIDS), it has been demonstrated that the regulatory effect of the ...
Bjørn Steen, Skålhegg, Ane, Funderud, Heidi Hatledal, Henanger, Tilahun Tolesa, Hafte, Anja Camilla, Larsen, Anne-Katrine, Kvissel, Sissel, Eikvar, Sigurd, Ørstavik   +7 more
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Effect of cAMP-dependent protein kinase A (PKA) on HCV nucleocapsid assembly and degradation

Biochemistry and Cell Biology, 2007
The primary function of the hepatitis C virus (HCV) core protein is genome encapsidation. Core protein is also subject to post-translational modifications that can impact on the assembly process. In this report, we have studied the effect of cAMP-dependent protein kinase A (PKA) phosphorylation on its assembly and stability in a yeast Pichia pastoris ...
Nathalie, Majeau, Marilène, Bolduc, Jean-Baptiste, Duvignaud, Rémi, Fromentin, Denis, Leclerc   +4 more
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α/β-tubulin are A kinase anchor proteins for type I PKA in neurons

Brain Research, 2009
Expression, localization and regulation of different cAMP-dependent protein kinase A (PKA) subunits account for specificity in the intracellular cAMP/PKA signaling pathway. In Aplysia neurons, two classes of PKA (I and II) differing in their regulatory (R) subunits have been characterized. Type I is mostly soluble in the cell body, and type II enriched
Takeshi, Kurosu, A Iván, Hernández, Jason, Wolk, Jinming, Liu, James H, Schwartz   +4 more
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The transcription factor FOXM1c is activated by protein kinase CK2, protein kinase A (PKA), c-Src and Raf-1

Biochemical and Biophysical Research Communications, 2011
The transcription factor FOXM1c possesses a very strong C-terminal TAD (transactivation domain), but full-length FOXM1c is only a weak transactivator because the TAD is completely inhibited by the auto-inhibitory N-terminus. The N-terminus blocks the TAD by directly binding to the TAD.
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