Results 71 to 80 of about 1,861,293 (359)
Protein kinase C coordinates histone H3 phosphorylation and acetylation
eLife, 2015 The re-assembly of chromatin following DNA replication is a critical event in the maintenance of genome integrity. Histone H3 acetylation at K56 and phosphorylation at T45 are two important chromatin modifications that accompany chromatin assembly.
Zoulfia Darieva +3 more
doaj +1 more source
Protein kinase FAM20C—when subcellular localization matters
FEBS Letters, EarlyView.FAM20C is a Golgi‐resident kinase that phosphorylates proteins along the entire secretory pathway. The presence of potential FAM20C substrates in the cytoplasm or nucleus raises the question of how the kinase and its substrates encounter each other. Protein kinases achieve signaling specificity through consensus sequence recognition and subcellular ...
Francesca Noventa, Mauro Salvi
wiley +1 more source
Protein kinase C in transmembrane signalling [PDF]
FEBS Letters, 1990 Protein kinase C functions as the transducer of a second messenger, diacylglycerol, and is the major receptor for tumour‐promoting phorbol esters. The enzyme is a family of proteins with closely but distinct structures and individual enzymological properties.
Anna Faragó, Yasutomi Nishizuka
openaire +3 more sources
Epicatechin induces NF-kappa B, activator rotein-1 (AP-1) and nuclear transcription factor erythroid 2p45-related factor-2 (Nrf2) via phosphatidylinositol-3-kinase/protein kinase B (PI3K/AKT) and extracellular regulated kinase (ERK) signalling in HepG2 cells [PDF]
, 2009 The dietary flavonoid epicatechin has been reported to exhibit a wide range of biological activities. The objective of the present study was to investigate the time-dependent regulation by epicatechin on the activity of the main transcription factors (NF-
Bravo, Laura +5 more
core +4 more sources
RAD50 missense variants differentially affect the DNA damage response and mitotic progression
FEBS Letters, EarlyView.RAD50 incorporates into the MRN complex and initiates the DNA damage response. Furthermore, RAD50 promotes mitotic progression. RAD50 missense variants capable of forming an MRN complex supported the DNA damage response and mitotic features to different extents in complementation experiments, indicating these functions are separable and might impact ...
Hanna Redeker +9 more
wiley +1 more source
Frontiers in Pharmacology, 2020 FGIN-1-27 is a synthetic mitochondrial diazepam binding inhibitor receptor (MDR) agonist that has demonstrated pro-apoptotic, anti-anxiety, and steroidogenic activity in various studies.
Jinpeng Lv +6 more
doaj +1 more source
Galpha 12 and Galpha 13 Are Phosphorylated during Platelet Activation [PDF]
, 1996 The ubiquitously expressed G-proteins G12 and G13 whose function is currently not clear have been shown to be activated in platelet membranes through receptors that stimulate platelet aggregation. We used intact human platelets to determine whether alpha
Hu, Yi-Hui +2 more
core
Mapping the evolution of mitochondrial complex I through structural variation
FEBS Letters, EarlyView.Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin +2 more
wiley +1 more source
Journal of Ayurveda and Integrative Medicine, 2017 Background: Macrophages are the first line of defense and constitute important participant in the bi-directional interaction between innate and specific immunity. Macrophages are in a quiescent form and get activated when given a stimulus.
Priti More, Kalpana Pai
doaj +1 more source
Tumor suppression by RNA from C/EBPβ 3'UTR through the inhibition of protein kinase Cε activity. [PDF]
PLoS ONE, 2011 BACKGROUND: Since the end of last century, RNAs from the 3'untranslated region (3'UTR) of several eukaryotic mRNAs have been found to exert tumor suppression activity when introduced into malignant cells independent of their whole mRNAs.
Ying Wang, Da-Quan Sun, Ding-Gan Liu
doaj +1 more source