Results 71 to 80 of about 2,013,902 (341)
A three-state kinetic mechanism for scaffold mediated signal transduction [PDF]
, 2008 Signaling events in eukaryotic cells are often guided by a scaffolding protein. Scaffold proteins assemble multiple proteins in a spatially localized signaling complex and exert numerous physical effects on signaling pathways. To study these effects, we consider a minimal, three-state kinetic model of scaffold mediated kinase activation.
arxiv +1 more source
LAST: Latent Space Assisted Adaptive Sampling for Protein Trajectories [PDF]
arXiv, 2022 Molecular dynamics (MD) simulation is widely used to study protein conformations and dynamics. However, conventional simulation suffers from being trapped in some local energy minima that are hard to escape. Thus, most computational time is spent sampling in the already visited regions.
arxiv
Protein kinase C in transmembrane signalling [PDF]
FEBS Letters, 1990 Protein kinase C functions as the transducer of a second messenger, diacylglycerol, and is the major receptor for tumour‐promoting phorbol esters. The enzyme is a family of proteins with closely but distinct structures and individual enzymological properties.
Anna Faragó, Yasutomi Nishizuka
openaire +3 more sources
A major role for protein kinase C in calcium-activated exocytosis in permeabilised adrenal chromaffin cells [PDF]
, 1988 The role of endogenously activated protein kinase C in calcium-activated exocytosis was examined in digitonin-permeabilised bovine adrenal chromaffin cells.
Burgoyne, Robert D. +2 more
core +1 more source
FEBS Letters, EarlyView.Spot‐14 and Spot‐14R play distinct roles in regulating metabolism in brown and beige adipocytes. While both influence lipid and glucose pathways, Spot‐14 uniquely controls thermogenic gene expression. This dual regulation balances energy storage and heat production, highlighting potential therapeutic targets for obesity and metabolic disorders. Spot 14
Lidia Itzel Castro‐Rodríguez +3 more
wiley +1 more source
Journal of Ayurveda and Integrative Medicine, 2017 Background: Macrophages are the first line of defense and constitute important participant in the bi-directional interaction between innate and specific immunity. Macrophages are in a quiescent form and get activated when given a stimulus.
Priti More, Kalpana Pai
doaj +1 more source
Predicting Relative Populations of Protein Conformations without a Physics Engine Using AlphaFold2 [PDF]
arXiv, 2023 This paper presents a novel approach for predicting the relative populations of protein conformations using AlphaFold 2, an AI-powered method that has revolutionized biology by enabling the accurate prediction of protein structures. While AlphaFold 2 has shown exceptional accuracy and speed, it is designed to predict proteins' single ground state ...
arxiv
Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation
FEBS Letters, EarlyView.Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley +1 more source
Frontiers in Pharmacology, 2020 FGIN-1-27 is a synthetic mitochondrial diazepam binding inhibitor receptor (MDR) agonist that has demonstrated pro-apoptotic, anti-anxiety, and steroidogenic activity in various studies.
Jinpeng Lv +6 more
doaj +1 more source
Conformational changes in human fibrinogen after in vitro phosphorylation and their relation to fibrinogen behaviour [PDF]
, 1990 The far-ultraviolet circular dichroism spectra of fibrinogens phosphorylated by protein kinase C or casein kinase II indicated a conformational change corresponding to an increase in ordered secondary structure. The spectra of protein kinase A- or casein
Björk, Ingemar, Martin, Steven C.
core +1 more source