Results 71 to 80 of about 3,523,322 (409)

Protein Kinase C Inhibitors Reduce SARS-CoV-2 Replication in Cultured Cells

Microbiology Spectrum, 2022
Infection by severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) has posed a severe threat to global public health. The current study revealed that several inhibitors of protein kinases C (PKCs) possess protective activity against SARS ...
Changbai Huang, Fei Feng, Yongxia Shi, Wenhui Li, Ziqiao Wang, Yunkai Zhu, Shuai Yuan, Dandan Hu, Jun Dai, Qiqi Jiang, Rong Zhang, Chao Liu, Ping Zhang   +12 more
doaj   +1 more source

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

FEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu, Huseyn Babayev, Ismail Ogulur, Sena Ardicli, Yagiz Pat, Duygu Yazici, Bingjie Zhao, Lihong Chang, Xiaoqing Liu, Paolo D'Avino, Manru Li, Ceren Biçer, Fatma Hacer Kurtoğlu Babayev, Raja Dhir, Kari C. Nadeau, Marie‐Charlotte Brüggen, Mubeccel Akdis, Cezmi A. Akdis   +17 more
wiley   +1 more source

Galpha 12 and Galpha 13 Are Phosphorylated during Platelet Activation [PDF]

, 1996
The ubiquitously expressed G-proteins G12 and G13 whose function is currently not clear have been shown to be activated in platelet membranes through receptors that stimulate platelet aggregation. We used intact human platelets to determine whether alpha
Hu, Yi-Hui, Offmanns, Stefan, Simon, Melvin I.   +2 more
core  

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Tumor suppression by RNA from C/EBPβ 3'UTR through the inhibition of protein kinase Cε activity. [PDF]

PLoS ONE, 2011
BACKGROUND: Since the end of last century, RNAs from the 3'untranslated region (3'UTR) of several eukaryotic mRNAs have been found to exert tumor suppression activity when introduced into malignant cells independent of their whole mRNAs.
Ying Wang, Da-Quan Sun, Ding-Gan Liu
doaj   +1 more source

Regulation of sertoli-germ cell adherens junction dynamics via changes in protein-protein interactions of the N-cadherin-β-catenin protein complex which are possibly mediated by c-Src and myotubularin-related protein 2: An in vivo study using an androgen suppression model [PDF]

, 2005
Using a well characterized model of cell-cell actin-based adherens junction (AJ) disruption by suppressing the intratesticular testosterone level in adult rats with testosterone-estradiol implants, we have confirmed earlier findings that Sertoli-germ ...
Cheng, CY, Lee, NPY, Lee, WM, Mruk, DD, Wong, CH, Xia, W, Zhang, J   +6 more
core   +1 more source

Phosphorylation of Hepatitis C Virus Core Protein by Protein Kinase A and Protein Kinase C

Virology, 2002
Hepatitis C virus (HCV) core protein can form capsid-like particles and is believed to be the viral capsid protein. Besides its structural functions, this protein is also known to possess multiple regulatory functions. In this article, we have studied the possible phosphorylation of HCV core protein in two different human liver-derived cell lines Huh7 ...
Jing-Hsiung Ou, Wen Lu
openaire   +3 more sources

Interaction of protein kinase C ζ with ZIP, a novel protein kinase C-binding protein [PDF]

Proceedings of the National Academy of Sciences, 1997
The atypical protein kinase C (PKC) member PKC-ζ has been implicated in several signal transduction pathways regulating differentiation, proliferation or apoptosis of mammalian cells. We report here the identification of a cytoplasmic and membrane-associated protein that we name zeta-interacting protein (ZIP) and that interacts with the ...
Ferdi Grawe, Axel Puls, Sandra Schmidt, Silvia Stabel   +3 more
openaire   +3 more sources

ERBIN limits epithelial cell plasticity via suppression of TGF‐β signaling

FEBS Letters, EarlyView.
In breast and lung cancer patients, low ERBIN expression correlates with poor clinical outcomes. Here, we show that ERBIN inhibits TGF‐β‐induced epithelial‐to‐mesenchymal transition in NMuMG breast and A549 lung adenocarcinoma cell lines. ERBIN suppresses TGF‐β/SMAD signaling and reduces TGF‐β‐induced ERK phosphorylation.
Chao Li, Gerard van der Zon, Peter ten Dijke, Tong Shen   +3 more
wiley   +1 more source

Effects of Newly Synthesized DCP-LA-Phospholipids on Protein Kinase C and Protein Phosphatases

Cellular Physiology and Biochemistry, 2013
Background/Aims: The linoleic acid derivative DCP-LA selectively activates PKCε and inhibits protein phosphatase 1 (PP1). In the present study, we have newly synthesized phosphatidyl-ethanolamine, -serine, -choline, and -inositol containing DCP-LA at the
Takeshi Kanno, Ayako Tsuchiya, Tadashi Shimizu, Syuhei Nakao, Akito Tanaka, Tomoyuki Nishizaki   +5 more
doaj   +1 more source