Results 251 to 260 of about 18,219,543 (287)

Protein kinase R and the metabolic syndrome

Journal of Cellular Biotechnology, 2015
Abstract Metabolic syndrome greatly increases the risk for developing metabolic and cardiovascular disorders and has reached epidemic proportions globally. Despite recent advances in medical science, scientific understandings on the root mechanisms of metabolic syndrome are still not fully understood, and such insufficient knowledge contributes to the ...
Bahal, Rishabh, Lakhani, Prit, Bhat, Audesh, Kondiparthi, Lavanya, Dhar, Indu, Desai, Kaushik, Dhar, Arti   +6 more
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The role of protein kinase R in placental inflammation, mtUPR and apoptosis

Placenta, 2023
Placental inflammation is implicated in the pathophysiology of many pregnancy complications, including fetal growth restriction, preeclampsia, gestational diabetes, and choriocarcinoma. Mitochondrial dysfunction, one of the outcomes of placental inflammation, is characterized by loss of membrane potential, accumulation of oxygen radicals, mitochondrial
Umut Kerem, Kolac, Gizem, Donmez Yalcin, Ramazan, Karayel, Abdullah, Yalcin   +3 more
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Structure and Function of the Protein Kinase R

2007
The protein kinase R (PKR) is an intracellular sensor of stress, exemplified by viral infection. Double-stranded (ds) RNA produced during viral replication activates PKR, which in turn arrests protein synthesis by phosphorylating the alpha subunit of the translation initiation factor eIF2.
A J, Sadler, B R G, Williams
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Kinase fusion proteins: intracellular R-proteins in plant immunity

Trends in Plant Science
Resistance (R) genes in the Triticeae tribe include not only genes encoding the canonical intracellular nucleotide-binding leucine-rich-repeat proteins (NLRs) but also genes encoding kinase fusion proteins (KFPs). Exploring these unconventional KFPs may expand the scope of effector-triggered immunity (ETI) and will have significant implications for ...
Yukun Liu, Shuguo Hou, Shisheng Chen
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Design and synthesis of novel protein kinase R (PKR) inhibitors

Molecular Diversity, 2016
Protein kinase RNA-activated (PKR) plays an important role in a broad range of intracellular regulatory mechanisms and in the pathophysiology of many human diseases, including microbial and viral infections, cancer, diabetes and neurodegenerative disorders. Recently, several potent PKR inhibitors have been synthesized.
Sagiv, Weintraub, Tali, Yarnitzky, Shirin, Kahremany, Iliana, Barrera, Olga, Viskind, Kobi, Rosenblum, Masha Y, Niv, Arie, Gruzman   +7 more
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Activation of protein kinase R in the manganese-induced apoptosis of PC12 cells

Toxicology, 2020
Manganese neurotoxicity leads to Parkinson-like symptoms associated with the apoptotic cell death of dopaminergic neurons. Protein kinase R (PKR) is a serine/threonine-specific protein kinase that has been implicated in several cellular signal transduction pathways, including the induction of apoptosis.
Kazuya Yagyu, Yuto Hasegawa, Mina Sato, Kentaro Oh-hashi, Yoko Hirata   +4 more
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Regulation of Protein Kinase R by Epstein-Barr Virus EBER1 RNA

Biochemistry, 2020
Protein kinase R (PKR) is a key antiviral component of the innate immune pathway and is activated by viral double-stranded RNAs (dsRNAs). Adenovirus-associated RNA 1 (VAI) is an abundant, noncoding viral RNA that functions as a decoy by binding PKR but not inducing activation, thereby inhibiting the antiviral response. In VAI, coaxial stacking produces
Cassie M. Zerbe, James L. Cole
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Orchestration of the Activation of Protein Kinase R by the RNA-Binding Motif

Journal of Interferon & Cytokine Research, 2010
The protein kinase R (PKR) constitutes part of the host antiviral response. PKR activation is regulated by the N-terminus of protein, which encodes tandem RNA-binding motifs (RBMs). The full capabilities of RBMs from PKR and other proteins have surpassed the narrow specificities initially determined as merely binding double-stranded RNA. Recognition of
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Identification of new inhibitors of protein kinase R guided by statistical modeling

Bioorganic & Medicinal Chemistry Letters, 2011
We report the identification of new, structurally diverse inhibitors of interferon-induced, double-stranded RNA-activated protein kinase (PKR) using a combined experimental and computational approach. A training set with which to build a predictive statistical model was generated by screening a set of 80 known Ser/Thr kinase inhibitors against ...
Ruslana, Bryk, Kangyun, Wu, Brian C, Raimundo, Paul E, Boardman, Ping, Chao, Graeme L, Conn, Eric, Anderson, James L, Cole, Nigel P, Duffy, Carl, Nathan, John H, Griffin   +10 more
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Crystallization of a Deletion Mutant of the R-subunit of cAMP Dependent Protein Kinase

Journal of Molecular Biology, 1993
A single deletion (delta 1 to 91) mutant of the regulatory subunit of the cAMP dependent protein kinase was crystallized. The crystals are hexagonal P6(1)22 (P6(5)22) with a = b = 88.7 A and c = 179.9 A. The crystals diffract to 3 A resolution. There is one molecule per asymmetric unit.
Y, Su, S S, Taylor, W R, Dostmann, N H, Xuong, K I, Varughese   +4 more
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