Results 1 to 10 of about 864,608 (212)
Journal of Advanced Research, 2023 Introduction: The structural and dynamic determinants that confer highly selective RET kinase inhibition are poorly understood. Objectives: To explore the druggability landscape of the RET active site in order to uncover structural and dynamic ...
Moustafa A. Shehata +6 more
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ERK5 Inhibition Induces Autophagy-Mediated Cancer Cell Death by Activating ER Stress
Frontiers in Cell and Developmental Biology, 2021 Autophagy is a highly conserved intracellular process that preserves cellular homeostasis by mediating the lysosomal degradation of virtually any component of the cytoplasm.
Andrés Gámez-García +12 more
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Scientific Reports, 2023 Resistance to therapy remains a major obstacle in cancer management. Although treatment with hormone and CDK4/6 inhibitors is successful in luminal breast cancer, resistance to these treatments is frequent, highlighting the need for novel therapeutic ...
María Jimena Rodriguez +12 more
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Nature Communications, 2023 Autophosphorylation controls the transition between discrete functional and conformational states in protein kinases, yet the structural and molecular determinants underlying this fundamental process remain unclear.
Hipólito Nicolás Cuesta-Hernández +10 more
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Protein kinases in cardiovascular diseases
Chinese Medical Journal, 2022 . Cardiovascular disease (CVD) remains the leading cause of death worldwide. Therefore, exploring the mechanism of CVDs and critical regulatory factors is of great significance for promoting heart repair, reversing cardiac remodeling, and reducing ...
Jiawen Chen +6 more
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A framework for classification of prokaryotic protein kinases. [PDF]
PLoS ONE, 2010 BACKGROUND: Overwhelming majority of the Serine/Threonine protein kinases identified by gleaning archaeal and eubacterial genomes could not be classified into any of the well known Hanks and Hunter subfamilies of protein kinases.
Nidhi Tyagi +2 more
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Author Correction: YAP1/TAZ drives ependymoma-like tumour formation in mice
Nature Communications, 2020 An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Noreen Eder +14 more
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Toxoplasma and Plasmodium protein kinases: roles in invasion and host cell remodelling [PDF]
, 2011 Some apicomplexan parasites have evolved distinct protein kinase families to modulate host cell structure and function. Toxoplasma gondii rhoptry protein kinases and pseudokinases are involved in virulence and modulation of host cell signalling.
Abdi +105 more
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YAP1/TAZ drives ependymoma-like tumour formation in mice
Nature Communications, 2020 YAP1 gene fusions are found in subgroups of paediatric ependymomas. Here the authors show that YAP1 activation in NeuroD6 positive neuronal precursor cells can induce ependymoma-like tumours in mice.
Noreen Eder +14 more
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Tv-RIO1 – an atypical protein kinase from the parasitic nematode Trichostrongylus vitrinus [PDF]
, 2008 Background: Protein kinases are key enzymes that regulate a wide range of cellular processes, including cell-cycle progression, transcription, DNA replication and metabolic functions. These enzymes catalyse the transfer of phosphates to serine, threonine
Gasser, Robin B. +3 more
core +6 more sources