Results 1 to 10 of about 800,949 (384)
Positional information readout in $Ca^{2+}$ signaling [PDF]
Phys. Rev. Lett. 123, 058102 (2019), 2017 Living cells respond to spatial signals. Signal transmission to the cell interior often involves the release of second messengers like $Ca^{2+}$ . They will eventually trigger a physiological response by activating kinases that in turn activate target proteins through phosphorylation. Here, we investigate theoretically how positional information can be
Kruse, Karsten +2 more
arxiv +3 more sources
Alternative Splicing in Oncogenic Kinases: From Physiological Functions to Cancer [PDF]
Journal of Nucleic Acids, 2012 Among the 518 protein kinases encoded by the human kinome, several of them act as oncoproteins in human cancers. Like other eukaryotic genes, oncogenes encoding protein kinases are frequently subjected to alternative splicing in coding as well as ...
Sabine Druillennec +2 more
doaj +4 more sources
Comparative kinomics of human and chimpanzee reveal unique kinship and functional diversity generated by new domain combinations [PDF]
BMC Genomics, 2008 Background Phosphorylation by protein kinases is a common event in many cellular processes. Further, many kinases perform specialized roles and are regulated by non-kinase domains tethered to kinase domain. Perturbation in the regulation of kinases leads
Martin Juliette +2 more
doaj +4 more sources
Inferring the Sign of Kinase-Substrate Interactions by Combining Quantitative Phosphoproteomics with a Literature-Based Mammalian Kinome Network [PDF]
, 2010 Protein phosphorylation is a reversible post-translational modification commonly used by cell signaling networks to transmit information about the extracellular environment into intracellular organelles for the regulation of the activity and sorting of proteins within the cell.
Hernandez, Marylens +4 more
arxiv +3 more sources
Functional diversity of human protein kinase splice variants marks significant expansion of human kinome [PDF]
BMC Genomics, 2009 Background Protein kinases are involved in diverse spectrum of cellular processes. Availability of draft version of the human genomic data in the year 2001 enabled recognition of repertoire of protein kinases.
Anamika Krishanpal +2 more
doaj +4 more sources
Analysis of the human kinome using methods including fold recognition reveals two novel kinases. [PDF]
PLoS ONE, 2008 Protein sequence similarity is a commonly used criterion for inferring the unknown function of a protein from a protein of known function. However, proteins can diverge significantly over time such that sequence similarity is difficult, if not impossible,
Kristine M Briedis +2 more
doaj +7 more sources
Protein Kinases in Leukemias [PDF]
Cancers, 2021 Protein kinases (PK) make up around 2% of the human genome and their expression profile varies depending on the organ and tissue [...]
Paulo De Sepulveda, Jean-Max Pasquet
openaire +4 more sources
ERK5 Inhibition Induces Autophagy-Mediated Cancer Cell Death by Activating ER Stress
Frontiers in Cell and Developmental Biology, 2021 Autophagy is a highly conserved intracellular process that preserves cellular homeostasis by mediating the lysosomal degradation of virtually any component of the cytoplasm.
Andrés Gámez-García +12 more
doaj +1 more source
Scientific Reports, 2023 Resistance to therapy remains a major obstacle in cancer management. Although treatment with hormone and CDK4/6 inhibitors is successful in luminal breast cancer, resistance to these treatments is frequent, highlighting the need for novel therapeutic ...
María Jimena Rodriguez +12 more
doaj +1 more source
, 2021 Proteins are the work horses of the cell. As regulators of protein function, protein kinases are involved in the control of cellular functions via intricate signalling pathways, allowing for fine tuning of physiological functions.
core +1 more source