Results 1 to 10 of about 6,498,377 (268)

Mapping proteome-wide targets of protein kinases in plant stress responses

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance Despite the importance of phosphorylation-dependent signaling for cellular physiology, identification of kinase substrates remains very challenging.
Pengcheng Wang, Chuan-Chih Hsu, Yanyan Du, Yanyan Du, Peipei Zhu, Chunzhao Zhao, Chunzhao Zhao, Xing Fu, Chunguang Zhang, J. S. Paez, A. Macho, W. Tao, Jian-Kang Zhu, Jian-Kang Zhu   +13 more
semanticscholar   +1 more source

The Landscape of Atypical and Eukaryotic Protein Kinases.

TIPS - Trends in Pharmacological Sciences, 2019
Kinases are attractive anticancer targets due to their central role in the growth, survival, and therapy resistance of tumor cells. This review explores the two primary kinase classes, the eukaryotic protein kinases (ePKs) and the atypical protein ...
Georgi K. Kanev, C. de Graaf, I. D. de Esch, R. Leurs, T. Würdinger, B. Westerman, A. Kooistra   +6 more
semanticscholar   +1 more source

Progress towards a public chemogenomic set for protein kinases and a call for contributions

bioRxiv, 2017
Protein kinases are highly tractable targets for drug discovery. However, the biological function and therapeutic potential of the majority of the 500+ human protein kinases remains unknown.
D. Drewry, C. Wells, D. Andrews, R. Angell, H. Al-Ali, Alison D. Axtman, Stephen J. Capuzzi, J. Elkins, P. Ettmayer, Mathias Frederiksen, O. Gileadi, N. Gray, Alice Hooper, S. Knapp, S. Laufer, U. Luecking, M. Michaelides, S. Müller, E. Muratov, R. Denny, K. Saikatendu, Daniel, K. Treiber, W. Zuercher, T. Willson   +24 more
semanticscholar   +1 more source

The Regulation of AP-1 Activity by Mitogen-activated Protein Kinases (*)

Journal of Biological Chemistry, 1995
AP-1 is a collection of dimeric sequence specific, DNA binding, transcriptional activators composed ofJun and Fos subunits. The composition, the level and the activity of AP1 complexes are regulated in response to extracellular stimuli. An important role
M. Karin
semanticscholar   +1 more source

Auxin efflux by PIN-FORMED proteins is activated by two different protein kinases, D6 PROTEIN KINASE and PINOID

eLife, 2014
The development and morphology of vascular plants is critically determined by synthesis and proper distribution of the phytohormone auxin. The directed cell-to-cell distribution of auxin is achieved through a system of auxin influx and efflux ...
M. Zourelidou, Birgit Absmanner, Benjamin Weller, Inês C R Barbosa, B. Willige, A. Fastner, V. Streit, S. Port, J. Colcombet, Sergio de la Fuente van Bentem, H. Hirt, B. Kuster, W. Schulze, Ulrich Z. Hammes, C. Schwechheimer   +14 more
semanticscholar   +1 more source

Mechanisms of regulation of SNF1/AMPK/SnRK1 protein kinases

Frontiers in Plant Science, 2014
The SNF1 (sucrose non-fermenting 1)-related protein kinases 1 (SnRKs1) are the plant orthologs of the budding yeast SNF1 and mammalian AMPK (AMP-activated protein kinase).
P. Crozet, Leonor Margalha, Ana Confraria, Américo Rodrigues, Cláudia Martinho, Mattia Adamo, C. A. Elias, Elena Baena-González   +7 more
semanticscholar   +1 more source

SUMO enables substrate selectivity by mitogen-activated protein kinases to regulate immunity in plants [PDF]

, 2021
Vivek Verma, Anjil Kumar Srivastava, Catherine Gough, Alberto Campanaro, Moumita Srivastava, Rebecca Morrell, Joshua Joyce, Mark Bailey, Cunjin Zhang, Patrick J. Krysan, Ari Sadanandom   +10 more
openalex   +1 more source

Mitogen-Activated Protein Kinases and Reactive Oxygen Species: How Can ROS Activate MAPK Pathways?

Journal of signal transduction, 2011
Mitogen-activated protein kinases (MAPKs) are serine-threonine protein kinases that play the major role in signal transduction from the cell surface to the nucleus.
Yong Son, Y. Cheong, Nam‐Ho Kim, Hun-taeg Chung, D. Kang, H. Pae   +5 more
semanticscholar   +1 more source

Complexes between the LKB1 tumor suppressor, STRADα/β and MO25α/β are upstream kinases in the AMP-activated protein kinase cascade

Journal of Biology, 2003
Background The AMP-activated protein kinase (AMPK) cascade is a sensor of cellular energy charge that acts as a 'metabolic master switch' and inhibits cell proliferation. Activation requires phosphorylation of Thr172 of AMPK within the activation loop by
S. Hawley, J. Boudeau, J. L. Reid, K. J. Mustard, Lina Udd, T. Mäkelä, D. Alessi, G. Hardie   +7 more
semanticscholar   +1 more source

The roles of protein kinases in learning and memory.

Learning & memory (Cold Spring Harbor, N.Y.), 2013
In the adult mammalian brain, more than 250 protein kinases are expressed, but only a few of these kinases are currently known to enable learning and memory.
K. Giese, K. Mizuno
semanticscholar   +1 more source