Results 31 to 40 of about 6,714,405 (407)

Protein Kinase C [PDF]

IUBMB Life, 2000
Phosphorylation is a universal language used by cells to relay information between and within cells. One family of kinases that plays a key role in transducing information is the protein kinase C family. Members of this family interpret information from signals that result in phospholipid hydrolysis; they communicate to substrates throughout the cell ...
openaire   +3 more sources

Extracellular signal-regulated kinases mediate the enhancing effects of inflammatory mediators on resurgent currents in dorsal root ganglion neurons [PDF]

, 2019
Previously we reported that a group of inflammatory mediators significantly enhanced resurgent currents in dorsal root ganglion neurons. To understand the underlying intracellular signaling mechanism, we investigated the effects of inhibition of ...
Cummins, Theodore R., Knopp, Kelly L., Krajewski, Jeffrey L., McDermott, Jeff S., Nisenbaum, Eric S., Tan, Zhi-Yong, Wu, Bin   +6 more
core   +1 more source

Roscovitine Targets, Protein Kinases and Pyridoxal Kinase [PDF]

Journal of Biological Chemistry, 2005
(R)-Roscovitine (CYC202) is often referred to as a "selective inhibitor of cyclin-dependent kinases." Besides its use as a biological tool in cell cycle, neuronal functions, and apoptosis studies, it is currently evaluated as a potential drug to treat cancers, neurodegenerative diseases, viral infections, and glomerulonephritis.
Bach, S., Knockaert, M., Reinhardt, J., Lozach, O., Schmitt, S., Baratte, B., Koken, M., S. P., Coburn, Tang, L., Jiang, T., D. C., Liang, Galons, H., J. F., Dierick, L. A., Pinna, Meggio, F., Totzke, F., Schachtele, C., Lerman, A. S., Carnero, A., Wan, Y., Gray, N., Meijer, L.   +21 more
openaire   +6 more sources

Non-degradative Ubiquitination of Protein Kinases. [PDF]

PLoS Computational Biology, 2016
Growing evidence supports other regulatory roles for protein ubiquitination in addition to serving as a tag for proteasomal degradation. In contrast to other common post-translational modifications, such as phosphorylation, little is known about how non ...
K Aurelia Ball, Jeffrey R Johnson, Mary K Lewinski, John Guatelli, Erik Verschueren, Nevan J Krogan, Matthew P Jacobson   +6 more
doaj   +1 more source

Protein phosphorylation in yeast mitochondria [PDF]

, 1987
We describe the identification and submitochondrial localization of four protein kinases and of their target proteins in derepressed yeast mitochondria. The activity of one of the kinases depends on the presence of cyclic AMP (cAMP).
Ashwell, Bandlow, Bandlow, Barrera, Bradford, Chandrasekaran, Chock, Daum, De Vendittis, Dimino, Douglas, Eraso, Fang, Heil, Henriksson, Hixson, Kim, Kitagawa, Krebs, Lastick, Linn, Mahler, Mahler, Matsumoto, Matsumoto, Matsumoto, Pall, Racker, Rigobello, Rittenhouse, Rödel, Steinberg, Steinberg, Suissa, Towbin, Van der Plaat, Vardanis, Wang   +37 more
core   +2 more sources

Secreted protein kinases [PDF]

Trends in Biochemical Sciences, 2013
Protein kinases constitute one of the largest gene families and control many aspects of cellular life. In retrospect, the first indication for their existence was reported 130 years ago when the secreted protein, casein, was shown to contain phosphate.
Jack E. Dixon, Jack E. Dixon, Lorenzo A. Pinna, Vincent S. Tagliabracci   +3 more
openaire   +4 more sources

c-Jun N-Terminal Kinase in Inflammation and Rheumatic Diseases. [PDF]

, 2012
The c-Jun N-terminal kinases (JNKs) are members of the mitogen-activated protein kinase (MAPK) family and are activated by environmental stress. JNK is also activated by proinflammatory cytokines, such as TNF and IL-1, and Toll-like receptor ligands ...
Firestein, Gary S, Guma, Monica
core   +1 more source

Protein kinases as antituberculosis targets: The case of thymidylate kinases

Frontiers in Bioscience-Landmark, 2020
This review is a concise summary of studies involving the design, synthesis and characterization of potential inhibitors against thymidylate kinase of Mycobacterium tuberculosis.
Sudarkodi Sukumar, Arunika Krishnan, Mohammad Khurshid Alam Khan   +2 more
doaj   +1 more source

Structural and dynamic determinants for highly selective RET kinase inhibition reveal cryptic druggability

Journal of Advanced Research, 2023
Introduction: The structural and dynamic determinants that confer highly selective RET kinase inhibition are poorly understood. Objectives: To explore the druggability landscape of the RET active site in order to uncover structural and dynamic ...
Moustafa A. Shehata, Julia Contreras, Ana Martín-Hurtado, Aurane Froux, Hossam Taha Mohamed, Ahmed A. El-Sherif, Iván Plaza-Menacho   +6 more
doaj  

Leishmania infection engages non-receptor protein kinases differentially to persist in infected hosts

Frontiers in Immunology, 2016
Protein kinases play important roles in the regulation of cellular activities. In cells infected by pathogens, there is increasing appreciation that dysregulated expression of protein kinases promotes the success of intracellular infections.
Peter Epeh Kima, Naixin eZhang
doaj   +1 more source