Results 31 to 40 of about 875,741 (363)

Kinases on Double Duty: A Review of UniProtKB Annotated Bifunctionality within the Kinome

Biomolecules, 2022
Phosphorylation facilitates the regulation of all fundamental biological processes, which has triggered extensive research of protein kinases and their roles in human health and disease.
Aziz M. Rangwala, Victoria R. Mingione, George Georghiou, Markus A. Seeliger   +3 more
doaj   +1 more source

MAP3Kinase-dependent SnRK2-kinase activation is required for abscisic acid signal transduction and rapid osmotic stress response. [PDF]

, 2020
Abiotic stresses, including drought and salinity, trigger a complex osmotic-stress and abscisic acid (ABA) signal transduction network. The core ABA signalling components are snf1-related protein kinase2s (SnRK2s), which are activated by ABA-triggered ...
Ceciliato, Paulo HO, Dubeaux, Guillaume, Ge, Chennan, Hauser, Felix, Hsu, Po-Kai, Munemasa, Shintaro, Schroeder, Julian I, Takahashi, Yohei, Zhang, Jingbo, Zhang, Li, Zhao, Yunde   +10 more
core  

Analysis of somatic mutations across the kinome reveals loss-of-function mutations in multiple cancer types [PDF]

, 2017
In this study we use somatic cancer mutations to identify important functional residues within sets of related genes. We focus on protein kinases, a superfamily of phosphotransferases that share homologous sequences and structural motifs and have many ...
Bose, Ron, Kumar, Runjun D
core   +2 more sources

Exploring the chemotherapeutic potential of currently used kinase inhibitors: An update

Frontiers in Pharmacology, 2023
Protein kinases are enzymes that transfer phosphate to protein, resulting in the modification of the protein. The human genome encodes approximately 538 kinases.
Rajashri R. Naik, Ashok K. Shakya
doaj   +1 more source

JNK signalling in cancer: In need of new, smarter therapeutic targets [PDF]

, 2013
Copyright © 2013 The British Pharmacological Society. This is the accepted version of the following article: Bubici, C. and Papa, S. (2014), JNK signalling in cancer: in need of new, smarter therapeutic targets.
Adams, Ahmed, Anbalagan, Annunziata, Antonyak, Bain, Barbarulo, Barr, Behrens, Bennett, Bharti, Bogoyevitch, Bogoyevitch, Borsello, Bost, Carboni, Cazanave, Cellurale, Cellurale, Cellurale, Chang, Chang, Chauhan, Chen, Chen, Chen, Chen-Deutsch, Cho, Choi, Chromik, Cilloni, Cripe, Cui, Cui, Das, Davis, Deininger, Dérijard, Eferl, Estey, Farazi, Ferrandi, Finegan, Fuchs, Gaillard, Gao, Gao, Gilmore, Goenka, Graff, Gururajan, Hagiwara, He, Heo, Hess, Hideshima, Hideshima, Hideshima, Hirosumi, Ho, Huang, Hui, Hunot, Jaeschke, Jagtap, Jemal, Johnson, Kamenecka, Kaneto, Kaoud, Ke, Keats, Kersting, Kuan, Kuperwasser, Li, Llovet, Lloyd, LoGrasso, Luedde, Maclean, Maeda, Mamay, Manning, Manning, Min, Mucha, Murati, Nagata, Nateri, Ngoei, Ngoei, Nitta, Oleinik, Owens, Papa, Papa, Plantevin Krenitsky, Qiu, Raitano, Reinecke, Ricard, Rodrigues, Ronaldson, Roy, Sabapathy, Sakurai, Schramek, Seki, She, Siddiqui, Smeal, Srivastava, Stebbins, Su, Su, Szczepankiewicz, Takahashi, Tong, Tournier, Tsuiki, Waetzig, Wagner, Wang, Wang, Webster, Whitmarsh, Whitmarsh, Yamamoto, Yan, Yang, Yao, Yoon, Yoshida, Zhang, Zhang, Zhang, Zhang   +137 more
core   +2 more sources

Neuronal migration and protein kinases

Frontiers in Neuroscience, 2015
The formation of the six-layered structure of the mammalian cortex via the inside-out pattern of neuronal migration is fundamental to neocortical functions.
Toshio eOhshima
doaj   +1 more source

Phospho.ELM:a database of experimentally verified phosphorylation sites in eukaryotic proteins [PDF]

, 2004
BACKGROUND: Post-translational phosphorylation is one of the most common protein modifications. Phosphoserine, threonine and tyrosine residues play critical roles in the regulation of many cellular processes.
Blom, Nikolaj, Cameron, Scott, Diella, Francesca, Gemünd, Christine, Gibson, Toby J., Kuster, Bernhard, Linding, Rune, Sicheritz-Pontén, Thomas, Via, Allegra   +8 more
core   +4 more sources

Lipid activation of protein kinases

Journal of Lipid Research, 2009
Lipids acutely control the amplitude, duration, and subcellular location of signaling by lipid second messenger-responsive kinases. Typically, this activation is controlled by membrane-targeting modules that allosterically control the function of kinase ...
Alexandra C. Newton
doaj   +1 more source

KSP: an integrated method for predicting catalyzing kinases of phosphorylation sites in proteins

BMC Genomics, 2020
Background Protein phosphorylation by kinases plays crucial roles in various biological processes including signal transduction and tumorigenesis, thus a better understanding of protein phosphorylation events in cells is fundamental for studying protein ...
Hongli Ma, Guojun Li, Zhengchang Su
doaj   +1 more source

A mitotic kinase scaffold depleted in testicular seminomas impacts spindle orientation in germ line stem cells. [PDF]

, 2015
Correct orientation of the mitotic spindle in stem cells underlies organogenesis. Spindle abnormalities correlate with cancer progression in germ line-derived tumors.
Bucko, Paula, Canton, David, Gelman, Irwin, Hehnly, Heidi, Langeberg, Lorene K, Ogier, Leah, Santana, L Fernando, Scott, John D, Wordeman, Linda   +8 more
core   +1 more source