Heterologous prion-forming proteins interact to cross-seed aggregation in Saccharomyces cerevisiae [PDF]
Scientific Reports, 2017 The early stages of protein misfolding remain incompletely understood, as most mammalian proteinopathies are only detected after irreversible protein aggregates have formed.
Kathryn M. Keefer +2 more
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Intra-FCY1: a novel system to identify mutations that cause protein misfolding [PDF]
Frontiers in Genetics, 2023 Protein misfolding is a common intracellular occurrence. Most mutations to coding sequences increase the propensity of the encoded protein to misfold. These misfolded molecules can have devastating effects on cells.
N. Quan +4 more
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Exploring Protein Misfolding in Amyotrophic Lateral Sclerosis: Structural and Functional Insights [PDF]
BiomedicinesProtein functionality depends on its proper folding, making protein misfolding crucial for the function of proteins and, by extension, cells and the whole organism.
Ouliana Ivantsik +4 more
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Protein Misfolding and Aggregation in Proteinopathies: Causes, Mechanism and Cellular Response [PDF]
Diseases, 2023 Proteins are central to life functions. Alterations in the structure of proteins are reflected in their function. Misfolded proteins and their aggregates present a significant risk to the cell.
Mohammad Rehan Ajmal
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A widespread protein misfolding mechanism is differentially rescued in vitro by chaperones based on gene essentiality [PDF]
Nature CommunicationsProtein misfolding involving changes in non-covalent lasso entanglement (NCLE) status has been proposed based on simulations and biochemical assays of a small number of proteins.
Ian Sitarik +5 more
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Protein misfolding and mitochondrial dysfunction in glaucoma [PDF]
Frontiers in Cell and Developmental BiologyGlaucoma is a leading cause of irreversible blindness worldwide. Elevated intraocular pressure caused by restricted outflow of the aqueous humor leads to the degeneration of retinal ganglion cells (RGCs) and their axons.
Arunkumar Venkatesan +2 more
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C-reactive protein: the nexus between inflammation and protein misfolding diseases [PDF]
Frontiers in ImmunologyC-reactive protein (CRP), an acute-phase protein primarily produced by hepatocytes in response to pro-inflammatory cytokines, is a widely used clinical marker for inflammation and tissue damage. In its native state, CRP exists in a stable pentameric form
Abhishek Roy +19 more
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Proteostasis Response to Protein Misfolding in Controlled Hypertension [PDF]
Cells, 2022 Hypertension is the most determinant risk factor for cardiovascular diseases. Early intervention and future therapies targeting hypertension mechanisms may improve the quality of life and clinical outcomes.
Manuel Teixeira +12 more
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Editorial: Protein misfolding, altered mechanisms and neurodegeneration [PDF]
Frontiers in Molecular Neuroscience, 2023 Neha Gogia +7 more
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A dopamine metabolite stabilizes neurotoxic amyloid-β oligomers
Communications Biology, 2021 Cataldi et al. investigates the impact of the dopamine derivative DOPAL on the Aβ peptide oligomer formation. They report that DOPAL promotes the formation of stable Aβ oligomers that exert toxicity on neuroblastoma cells by increasing cytosolic calcium ...
Rodrigo Cataldi +15 more
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