Results 91 to 100 of about 92,071 (194)

Protein Aggregates and Polyglutamine Tracts In Neurodegenerative Disease [PDF]

, 2018
The incidence of neurodegenerative diseases such as Alzheimer\u27s Disease, Parkinson\u27s Disease, Huntington\u27s Disease and other Polyglutamine Diseases is projected to dramatically increase throughout the developed world, and yet the pathology of ...
Mack, John
core   +1 more source

In vivo conformational space and defects of misfolded CFTR variants by covalent protein painting

Nature Communications
In vivo characterization of protein structures and structural changes after perturbation is still a major challenge and has impacted our understanding of the molecular events involved in protein misfolding diseases.
Sandra Pankow, Tom Casimir Bamberger, Salvador Martínez-Bartolomé, Robin Park, John R. Yates   +4 more
doaj   +1 more source

Unraveling the Role of Proteinopathies in Parasitic Infections

Biomedicines
Proteinopathies, characterized by the misfolding, aggregation, and deposition of proteins, are hallmarks of various neurodegenerative and systemic diseases.
Mikołaj Hurła, Damian Pikor, Natalia Banaszek-Hurła, Alicja Drelichowska, Jolanta Dorszewska, Wojciech Kozubski, Elżbieta Kacprzak, Małgorzata Paul   +7 more
doaj   +1 more source

Protein evolution speed depends on its stability and abundance and on chaperone concentrations. [PDF]

, 2018
Proteins evolve at different rates. What drives the speed of protein sequence changes? Two main factors are a protein's folding stability and aggregation propensity. By combining the hydrophobic-polar (HP) model with the Zwanzig-Szabo-Bagchi rate theory,
Agozzino, Luca, Dill, Ken A
core   +1 more source

Characterization of a PNLIP variant identified in Amish pediatric patients with congenital pancreatic lipase deficiency

Journal of Lipid Research
Congenital pancreatic lipase deficiency (CPLD, OMIM #614338) is a rare exocrine pancreatic disorder presenting in late infancy with steatorrhea, fat-soluble vitamin deficiency, and low pancreatic lipase activity.
Grace E. Curry, Nicole L. Bertsch, Tran Quach, Rhonda Anderson, Neel Matiwala, Karlla W. Brigatti, Steven J. Wilhelm, Katie B. Williams, Mark E. Lowe, Zineb Ammous, Xunjun K. Xiao   +10 more
doaj   +1 more source

Phenylhydrazone-based endoplasmic reticulum proteostasis regulator compounds with enhanced biological activity

eLife
Pharmacological enhancement of endoplasmic reticulum (ER) proteostasis is an attractive strategy to mitigate pathology linked to etiologically diverse protein misfolding diseases.
Gabriel M Kline, Lisa Boinon, Adrian Guerrero, Sergei Kutseikin, Gabrielle Cruz, Marnie P Williams, Ryan J Paxman, William E Balch, Jeffery W Kelly, Tingwei Mu, R Luke Wiseman   +10 more
doaj   +1 more source

Protein Misfolding and Human Disease

The Scientific World Journal, 2002
Christopher Dobson
doaj   +1 more source

Protein Misfolding and Neurodegenerative Diseases

International Journal of Cell Biology, 2014
Alessio Cardinale, Roberto Chiesa, Michael Sierks   +2 more
doaj   +1 more source

Protein misfolding [PDF]

Nature, 2003
openaire   +1 more source

Challenges and limitations in computational prediction of protein misfolding in neurodegenerative diseases. [PDF]

Front Comput Neurosci, 2023
Krokidis MG, Dimitrakopoulos GN, Vrahatis AG, Exarchos TP, Vlamos P.   +4 more
europepmc   +1 more source