Results 111 to 120 of about 53,939 (158)

Fitness defects due to cytosolic protein misfolding in S. cerevisiae can be alleviated by decreasing mitochondrial protein import capacity

Zaidi Z, Dash DP, Sharma A, Kundu S, Bhatt S, Rao S, Padia K, Rai M, Chakraborty K.   +8 more
europepmc   +1 more source

Some of the next articles are maybe not open access.

Related searches:

Protein Misfolding and Aggregation

Biotechnology Progress, 2008
Interest in the problem of protein misfolding and aggregation has exploded in recent years for two reasons: (1) the sharp rise in the number and volume of therapeutic proteins produced commercially and (2) the recognition of the central role of protein aggregates in degenerative diseases.
Regina M, Murphy, Brent S, Kendrick
openaire   +2 more sources

The Misfolding of Proteins

2020
Protein folding is considered strongly linked with genetics. The deeper understanding of the mechanisms that allow the folding of proteins is expected to lead to advances in the pharmaceutical sector. The shape of a protein dictates its biological activity, and any exceptions from its natural form can lead to diseases such as Alzheimer's, Parkinson's ...
openaire   +2 more sources

Protein folding and misfolding

Nature, 2003
The manner in which a newly synthesized chain of amino acids transforms itself into a perfectly folded protein depends both on the intrinsic properties of the amino-acid sequence and on multiple contributing influences from the crowded cellular milieu.
openaire   +2 more sources

Protein Misfolding and Human Disease

Annual Review of Genomics and Human Genetics, 2006
Protein misfolding is a common event in living cells. In young and healthy cells, the misfolded protein load is disposed of by protein quality control (PQC) systems. In aging cells and in cells from certain individuals with genetic diseases, the load may overwhelm the PQC capacity, resulting in accumulation of misfolded proteins.
Niels, Gregersen, Peter, Bross, Søren, Vang, Jane H, Christensen   +3 more
openaire   +2 more sources

Protein misfolding in neurodegenerative diseases

Neuropathology and Applied Neurobiology, 2004
A common pathogenic mechanism shared by diverse neurodegenerative disorders, like Alzheimer's disease, Parkinson's disease, Huntington's disease and transmissible spongiform encephalopathies, may be altered protein homeostasis leading to protein misfolding and aggregation of a wide variety of different proteins in the form of insoluble fibrils ...
E I, Agorogiannis, G I, Agorogiannis, A, Papadimitriou, G M, Hadjigeorgiou   +3 more
openaire   +2 more sources

Protein degradation, aggregation, and misfolding

Movement Disorders, 2010
AbstractThe cellular surveillance systems guarantee proper removal of altered components from inside cells. Alterations of these systems in neurons have been proposed to be involved in the pathogenesis of different neurodegenerative disorders. In this review, we comment on the advances in our current understanding of how changes in the intracellular ...
Ana Maria, Cuervo, Esther S P, Wong, Marta, Martinez-Vicente   +2 more
openaire   +2 more sources

Protein misfolding in hemophilia

Over the past century, the development of advancements in hemophilia therapy has experienced unprecedented success, starting with virally contaminated blood product infusions and progressing to safe plasma-derived and recombinant factor replacements, non-factor based rebalancing agents, long-lasting gene therapies, and moving forward into an era of ...
Bilgimol, Chumappumkal Joseph, Juan A, De Pablo-Moreno, Nicca, Falah, Dana H, Simmons, Annette, von Drygalski   +4 more
openaire   +2 more sources

Misfolded Proteins and Human Diseases

Protein & Peptide Letters, 2004
Though protein folding is a regular phenomenon inside the cellular milieu, slight differences in the folding pattern of proteins may lead to disease-causing forms. Many diseases have been identified that are caused by these misfolded macromolecules and a considerable amount of focus is still directed towards better understanding of the processes that ...
M S, Nayeem, Rizwan H, Khan
openaire   +2 more sources

Principles of Protein Misfolding

2008
Publisher Summary This chapter discusses the principles of protein misfolding. The process of incorrect folding is called “protein misfolding.” It is associated with a number of pathological states in humans, collectively termed “protein-misfolding diseases.” Among these protein-misfolding diseases, amyloid diseases are characterized by the presence ...
openaire   +2 more sources