Results 111 to 120 of about 3,647,798 (263)
Chemistry – A European Journal, EarlyView.Balancing Act: Se─M bond serving as the fulcrum of the balance scale to compare the different weight of toxicity and therapeutic effects in biological environment. ABSTRACT The synthesis and characterization of organo‐selenium compounds have attracted considerable interest for decades, driven by the search for efficient catalysts and bioinspired ...
Matteo Filippi +6 more
wiley +1 more source
Protein folding assisted by chaperones
, 2015 Molecular chaperones are one of the most important cell defense mechanisms against protein aggregation and misfolding. These specialized proteins bind non-native states of other proteins and assist them in reaching a correctly folded and functional ...
Borges, JC, Ramos, CHI
core +1 more source
Biochemistry and Biophysics ReportsSignal peptides are a sequence of peptides located at the N-terminus of proteins and determine the protein secretion pathway and their destinations. The N-region is positively charged and influences the orientation of translocation.
Natalie G. Horgan +3 more
doaj +1 more source
DNA Nanotechnology Meets Peptide and Protein Self‐Assembly
Chemistry – A European Journal, EarlyView.Combining DNA nanotechnology with peptide and protein assembly provides complementary platforms for the rational engineering of functional biomaterials. This Perspective discusses the emerging field of self‐assembling DNA‐peptide and DNA‐protein hybrid systems that combine the structural precision and programmability of DNA nanotechnology with the ...
Marcel Hanke +4 more
wiley +1 more source
Molecular targets in protein misfolding and neurodegenerative disease /
Aimed at "drug discoverers"--I.e. any scientist who is interested in neurodegenerative diseases in general, and in finding disease-modifying treatments in particular - the first edition of Molecular Targets in Protein Misfolding and Neurodegenerative ...
Seneci, Pierfausto,author.
core
Role of intermediate states in protein folding and misfolding.
, 2014 Most proteins fold into their native structure through defined pathways which involve a limited number of transient intermediates. Intermediates play a relevant role in the folding process; many diseases of genetic nature are in fact coupled with protein
Santucci, R +10 more
core +1 more source
Developmental Dynamics, EarlyView.Abstract Background The promoters and enhancers of heat shock genes, such as the 1.5‐kb promoter of the zebrafish hsp70l gene, are valuable tools for temporal activation of transgenes. It has been widely purported that heat shock treatments result in ubiquitous expression of hsp70l‐driven transgenes.
Jong‐Su Park, Xiangyun Wei
wiley +1 more source
Remodeling of the conformational ensemble of the repeat domain of tau by an aggregation enhancer
, 2019 Misfolding of the microtubule‐associated protein Tau is a hallmark of Alzheimer disease and several other neurodegenerative disorders. Because of the dynamic nature of the Tau protein, little is known about the changes in Tau structure that occur during ...
Tepper, Katharina +7 more
core +1 more source
In vivo conformational space and defects of misfolded CFTR variants by covalent protein painting
Nature CommunicationsIn vivo characterization of protein structures and structural changes after perturbation is still a major challenge and has impacted our understanding of the molecular events involved in protein misfolding diseases.
Sandra Pankow +4 more
doaj +1 more source
Unraveling the Role of Proteinopathies in Parasitic Infections
BiomedicinesProteinopathies, characterized by the misfolding, aggregation, and deposition of proteins, are hallmarks of various neurodegenerative and systemic diseases.
Mikołaj Hurła +7 more
doaj +1 more source