Results 91 to 100 of about 3,647,798 (263)
Injectable Peptide‐Based Functional Amyloid Hydrogels as Tunable Depots for Sustained Drug Delivery
Advanced Science, EarlyView.An injectable and tunable peptide‐based functional amyloid hydrogel provides sustained insulin release while preserving insulin stability and bioactivity. The hydrogel enables prolonged glycemic regulation in vivo, exhibits excellent biocompatibility, and shows no detectable IAPP and α‐Syn heterologous cross‐seeding, highlighting its potential as a ...
Ranjit Shaw +4 more
wiley +1 more source
Nanoimaging for protein misfolding diseases
, 2010 Misfolding and aggregation of proteins are widespread phenomena leading to the development of numerous neurodegenerative disorders such as Parkinson\u27s, Alzheimer\u27s, and Huntington\u27s diseases.
Junping Yu +7 more
core +1 more source
The VES hypothesis and protein misfolding
Discrete and Continuous Dynamical Systems - S, 2011 Proteins function by changing conformation. These conformational changes, which involve the concerted motion of a large number of atoms are classical events but, in many cases, the triggers are quantum mechanical events such as chemical reactions. Here the initial quantum states after the chemical reaction are assumed to be vibrational excited states ...
openaire +2 more sources
Biomolecules, 2020 Many devastating neurodegenerative diseases are driven by the misfolding of normal proteins into a pathogenic abnormal conformation. Examples of such protein misfolding diseases include Alzheimer’s disease, Parkinson’s disease, Huntington’s disease ...
Cristóbal Marrero-Winkens +2 more
doaj +1 more source
Animal Models and Experimental Medicine, EarlyView.Animal models enable mechanistic testing of how ischemic injury disrupts neurovascular trafficking and drives cognitive vulnerability after stroke. Complementary models capture distinct vascular, cellular, white matter, and cognitive features of PSCI.
Pratchaya Kaewkaen
wiley +1 more source
Blood SOD1 Activity in ALS Patients Receiving Tofersen Treatment
Annals of Neurology, EarlyView.Objective The antisense oligonucleotide tofersen is the first disease‐modifying drug for SOD1‐related amyotrophic lateral sclerosis (ALS) and was approved because of its ability to reduce SOD1 protein and neurofilament levels. The effect of tofersen on SOD1 activity is unclear but of clinical relevance because homozygous SOD1 mutations, linked to ...
Katharina Goehring +18 more
wiley +1 more source
Estimating the mean first passage time of protein misfolding
, 2018 MFPT of the misfolded protein is directly correlated to the age of onset and appearance of misfolding diseases in humans.
Vishal Singh, Parbati Biswas
core +1 more source
Studies of protein folding and misfolding on the ribosome [PDF]
, 2023 Protein folding is one of the most important processes for maintaining cellular homeostasis. It begins co-translationally on the ribosome, however, it also competes with protein misfolding.
Plessa, Eleni
core +1 more source
Protein Misfolding Diseases and Therapeutic Approaches
, 2019 Protein folding is the process by which a polypeptide chain acquires its functional, native 3D structure. Protein misfolding, on the other hand, is a process in which proteins fails to fold into its native functional conformation.
Yadav, Kusum +4 more
core +1 more source
Protein misfolding disorders and macroautophagy
Current Opinion in Cell Biology, 2011 A large group of diseases, termed protein misfolding disorders, share the common feature of the accumulation of misfolded proteins. The possibility of a common mechanism underlying either the pathogenesis or therapy for these diseases is appealing. Thus, there is great interest in the role of protein degradation via autophagy in such conditions where ...
Menzies, Fiona M +2 more
openaire +2 more sources