Results 101 to 110 of about 3,647,798 (263)

Single-molecule studies of prion protein folding and misfolding [PDF]

, 2013
Protein folding involves a stochastic search through the configurational energy landscape towards the native structure. Although most proteins have evolved to fold efficiently into a unique native structure, misfolding (the formation of non-native ...
Yu, Hao
core   +1 more source

Cellular Chaperones As Therapeutic Targets in ALS to Restore Protein Homeostasis and Improve Cellular Function

Frontiers in Molecular Neuroscience, 2017
Heat shock proteins (Hsps) are ubiquitously expressed chaperone proteins that enable cells to cope with environmental stresses that cause misfolding and denaturation of proteins.
Bernadett Kalmar, Linda Greensmith, Linda Greensmith   +2 more
doaj   +1 more source

Disulfide Bonding in Neurodegenerative Misfolding Diseases

International Journal of Cell Biology, 2013
In recent years an increasing number of neurodegenerative diseases has been linked to the misfolding of a specific protein and its subsequent accumulation into aggregated species, often toxic to the cell.
Maria Francesca Mossuto
doaj   +1 more source

Template-directed protein misfolding in neurodegenerative disease

, 2012
Protein misfolding diseases represent a large burden to human health for which only symptomatic treatment is generally available. These diseases, such as Creutzfeldt-Jakob disease, amyotrophic lateral sclerosis, and the systemic amyloidoses, are ...
Guest, William Clay
core   +1 more source

Plant-Derived Nanomaterials and Protein Misfolding Disorders: Green Production Approaches, Biological Interactions, and Research Trends (2015–2025)

Applied Sciences
Protein misfolding and aggregation represent key pathological mechanisms in neurodegenerative and systemic amyloid disorders, yet disease-modifying therapeutic strategies remain limited.
Corina Dalia Toderescu, Iulia Cresneac, Alexandru Oancea, Svetlana Trifunschi, Melania Florina Munteanu, Casiana Boru   +5 more
doaj   +1 more source

Disulfide Bond–Modified Proteomics Reveals the Effects of Riboflavin on Protein Folding Dynamics

Animal Research and One Health, EarlyView.
Riboflavin deficiency impairs oxidative protein folding, causing ER misfolded protein accumulation, CHOP activation, and apoptosis, revealing a role of riboflavin in proteostasis. ABSTRACT Riboflavin is a crucial micronutrient essential for maintaining cellular homeostasis, acting as an important precursor for flavoproteins that utilize flavin ...
Bo Zhang, Shuisheng Hou, Jing Tang
wiley   +1 more source

Reporters of amyloid structural polymorphism

, 2014
Misfolding of proteins induced by environmental conditions or by the presence of destabilizing mutations often triggers squestration (aggresome formation) or cellular removal (unfolded protein response (UPR), autophagy) intracellular responses ...
Nilsson, Peter,, LeVine III, Harry,, Hammarström, Per,   +2 more
core  

Protein thermal stability in the undergraduate biochemistry laboratory: Exploring protein thermal stability with yeast alcohol dehydrogenase

Biochemistry and Molecular Biology Education, Volume 53, Issue 2, Page 209-217, March/April 2025.
Abstract We created a novel laboratory experience where undergraduate students explore the techniques used to study protein misfolding, unfolding, and aggregation. Despite the importance of protein misfolding and aggregation diseases, protein unfolding is not typically explored in undergraduate biochemistry laboratory classes.
Alison Bates, Kathryn M. Williams, Ann E. Hagerman   +2 more
wiley   +1 more source

Bridging the translational gap in clinical nanomedicine: From rational design to clinical reality

BMEMat, EarlyView.
Nanotechnology offers a multi‐faceted approach to modern healthcare, encompassing high‐sensitivity diagnostic imaging, innovative vaccine delivery, and targeted therapeutics. This review explores how these nanomedicine applications address critical challenges in cancer recurrence and the treatment of neurologic and respiratory diseases to combat rising
Ahmed H. Ghonaim, Marwa Ahmed El‐Naka, Wedad M. Nageeb, Atta Ullah Khan, Noura M. Seleem, Aliaa Abdelghafar, Doaa Zamel, Yang Liu, Qigai He, Wentao Li   +9 more
wiley   +1 more source

A biosensor toolbox for monitoring recombinant protein production in Escherichia coli

Frontiers in Bioengineering and Biotechnology
Recombinant protein production can be a challenging process. To help users troubleshoot and optimize experiments in Escherichia coli we have compiled and characterized a toolbox of biosensor plasmids.
Maurice Mürköster, Mateusz Balka, Christina J. Kamp, Judit Källström, Linus Karlsson, Claudia A. Rodriguez Aparicio, Erik Tunäng, Hanna-Louise Ögren, Silvia Theopold, Alister J. Cumming, Alex Toftgaard Nielsen, Daniel O. Daley   +11 more
doaj   +1 more source