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Modeling of Protein Misfolding in Disease
2008A short review of the results of molecular modeling of prion disease is presented in this chapter. According to the "one-protein theory" proposed by Prusiner, prion proteins are misfolded naturally occurring proteins, which, on interaction with correctly folded proteins may induce misfolding and propagate the disease, resulting in insoluble amyloid ...
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Involvement of molecular chaperone in protein-misfolding brain diseases
Biomedicine and Pharmacotherapy, 2022Nitu L Wankhede +2 more
exaly
Thermodynamic and kinetic approaches for drug discovery to target protein misfolding and aggregation
Expert Opinion on Drug Discovery, 2023Michele Vendruscolo
exaly
Mechanism of misfolding of the human prion protein revealed by a pathological mutation
Proceedings of the National Academy of Sciences of the United States of America, 2021Máximo Sanz-Hernández +2 more
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Protein-misfolding diseases and chaperone-based therapeutic approaches
FEBS Journal, 2006Tapan K Chaudhuri, Subhankar Paul
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