Results 151 to 160 of about 3,403,581 (279)

Covalent Modulation of Protein Misfolding and Aggregation Processes in the Context of Neurodegenerative Diseases. [PDF]

Arch Pharm (Weinheim)
Basagni F, Roggiolani E, Minarini A, Rosini M.   +3 more
europepmc   +1 more source

Directional information flow in human frataxin defines allosteric pathways connecting the hydrophobic core to the iron‐binding ridge

The FEBS Journal, EarlyView.
Human frataxin deficiency causes Friedreich's ataxia, yet how iron‐binding events are communicated across the protein is unclear. Using transfer entropy analysis of molecular dynamics simulations, we identify buried hydrophobic core leucines (LEU136, LEU140) as the source of directional signaling toward the iron‐binding acidic ridge.
Kevser Kübra Kırboğa, Ecir Uğur Küçüksille   +1 more
wiley   +1 more source

AI-driven insights into protein misfolding and innate immunity in neurodegenerative diseases. [PDF]

Front Immunol
Deng HX, Cao JL, Wu Y, Jiang SJ, Fang QQ, Zhu BY, Jiang YJ.   +6 more
europepmc   +1 more source

Integrated multitissue analysis reveals distinct oxidative stress responses during recovery from cold shock in the Amazonian fish Colossoma macropomum

Journal of Fish Biology, EarlyView.
Abstract Tambaqui (Colossoma macropomum) is a tropical fish widely cultivated in South America. The increasing demand for this species has heightened interest in its cultivation in subtropical regions with greater thermal variability, where cold shock may induce oxidative stress. This study evaluated the effects of cold shock and subsequent recovery on
Naiara Melo, Isaac Konig, Stefania Priscilla de Souza, Maria Fernanda Aquino Freitas, Daniella Aparecida de Jesus Paula, Ronald Kennedy Luz, Priscila Vieira Rosa, Luis David Solis Murgas   +7 more
wiley   +1 more source

Functional Proteomics and Biological Screening of Protein Misfolding Under ER Stress Conditions in a Neuroblastoma Cell Model. [PDF]

Curr Issues Mol Biol
Serra A, Morretta E, Pecoraro M, Monti MC, Pascale M, Franceschelli S.   +5 more
europepmc   +1 more source

Challenges and limitations in computational prediction of protein misfolding in neurodegenerative diseases. [PDF]

Front Comput Neurosci, 2023
Krokidis MG, Dimitrakopoulos GN, Vrahatis AG, Exarchos TP, Vlamos P.   +4 more
europepmc   +1 more source

Auxin response and PIN‐mediated transport in chlorophyte algae

Journal of Integrative Plant Biology, EarlyView.
Like multicellular plants, green algae respond to auxin and move it across their cells. However, their PIN‐like proteins do not act like plant auxin exporters, suggesting that basic auxin transport evolved early and specialized directional transport appeared later in plant evolution.
Adrijana Smoljan, Sarah Koutnik‐Abele, Dmitrii Vladimirtsev, Petr Klíma, Anita Bírošíková, Yuzhou Zhang, Jack Merrin, Maximilian Schuster, Katarina Kurtović, Ulrich Z. Hammes, Jan Petrášek, Jiří Friml   +11 more
wiley   +1 more source

Tracking Protein Misfolding and Oligomerization: A Temperature-Controlled Ion Mobility-Mass Spectrometry Approach. [PDF]

Anal Chem
Svingou D, McAlary L, Harrison JA, Zenobi R.   +3 more
europepmc   +1 more source

Transcriptomic profiling of subpopulations of mouse embryonic subplate neurons

Journal of Anatomy, EarlyView.
To study gene expression in subpopulations of cortical subplate neurons (Lpar1‐EGFP‐positive and D1B‐positive SpN clusters), we applied gene expression profiling, including bulk microarray analysis, single‐cell RNA sequencing (scRNA‐seq), and Visium spatial transcriptomics, and identified both overlapping and unique gene expression signatures ...
Hitomi Achiwa, Yuichiro Hara, Hideya Kawaji, Minori Oshima, Noe Kaneko, Ayumu Morioka, Anna Hoerder‐Suabedissen, Zoltán Molnár, Chiaki Ohtaka‐Maruyama   +8 more
wiley   +1 more source

Scalable assay to identify inhibitors of prion-like propagation of protein misfolding as potential therapeutics for neurodegeneration. [PDF]

Protein Sci
Narayan A, Neupane K, Woodside MT.
europepmc   +1 more source