Results 141 to 150 of about 92,071 (194)

Misfolded protein oligomers: mechanisms of formation, cytotoxic effects, and pharmacological approaches against protein misfolding diseases. [PDF]

Mol Neurodegener
Rinauro DJ, Chiti F, Vendruscolo M, Limbocker R.   +3 more
europepmc   +1 more source

Dysbiosis of the gut microbiota and its effect on α-synuclein and prion protein misfolding: consequences for neurodegeneration. [PDF]

Front Cell Infect Microbiol
Mahbub NU, Islam MM, Hong ST, Chung HJ.
europepmc   +1 more source

Sestrin2 drives ER-phagy in response to protein misfolding.

Dev Cell
De Leonibus C, Maddaluno M, Ferriero R, Besio R, Cinque L, Lim PJ, Palma A, De Cegli R, Gagliotta S, Montefusco S, Iavazzo M, Rohrbach M, Giunta C, Polishchuk E, Medina DL, Di Bernardo D, Forlino A, Piccolo P, Settembre C.   +18 more
europepmc   +1 more source

Fitness defects due to cytosolic protein misfolding inS. cerevisiaecan be alleviated by decreasing mitochondrial protein import capacity

Zaidi Z, Dash DP, Sharma A, Kundu S, Bhatt S, Rao S, Padia K, Rai M, Chakraborty K.   +8 more
europepmc   +1 more source

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Protein Misfolding and Aggregation

Biotechnology Progress, 2008
Interest in the problem of protein misfolding and aggregation has exploded in recent years for two reasons: (1) the sharp rise in the number and volume of therapeutic proteins produced commercially and (2) the recognition of the central role of protein aggregates in degenerative diseases.
Regina M, Murphy, Brent S, Kendrick
openaire   +2 more sources

Protein Misfolding: Optional Barriers, Misfolded Intermediates, and Pathway Heterogeneity

Journal of Molecular Biology, 2004
To investigate the character and role of misfolded intermediates in protein folding, a recombinant cytochrome c without the normally blocking histidine to heme misligation was studied. Folding remains heterogeneous as in the wild-type protein. Half of the population folds relatively rapidly to the native state in a two-state manner.
Mallela M G, Krishna, Yan, Lin, S Walter, Englander   +2 more
openaire   +2 more sources

The Misfolding of Proteins

2020
Protein folding is considered strongly linked with genetics. The deeper understanding of the mechanisms that allow the folding of proteins is expected to lead to advances in the pharmaceutical sector. The shape of a protein dictates its biological activity, and any exceptions from its natural form can lead to diseases such as Alzheimer's, Parkinson's ...
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Trashing misfolded membrane proteins

Science, 2014
A branch of the endoplasmic reticulum–associated protein degradation system degrades inner nuclear membrane proteins in yeast.
openaire   +1 more source

Protein Misfolding Cyclic Amplification

2012
Prion diseases are caused by a conformational conversion of the cellular prion protein (PrPC) to a pathological conformer (PrPSc). The “prion-only” hypothesis suggests that PrPSc is the infectious agent that propagates the disease acting as a template for the conversion of PrPC.
Moda F., Pritzkow S., Soto C.
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Proteomics in protein misfolding diseases

Clinical Chemistry and Laboratory Medicine, 2009
Protein misfolding and deposition as amyloid, with consequent tissue damage, plays a key role in the group of diseases generically termed amyloidoses. In the systemic forms, amyloid deposition is widespread and causes severe dysfunction of vital organs.
STOPPINI, MONICA, LAVATELLI, FRANCESCA, GIORGETTI, SOFIA, MORATTI, REMIGIO, BELLOTTI, VITTORIO, MERLINI, GIAMPAOLO, Laura Obici, Loredana Marchese   +7 more
openaire   +3 more sources