Results 91 to 100 of about 30,129 (222)

Optical control over monomeric and multimeric protein hybrids [PDF]

, 2017
Living materials are based on proteins that adapt and change in structure and function continuously when in use; cellular microtubules, ATP synthases and ribosomes are but a few examples. Breathing life into semi-synthetic materials would allow improved understanding over protein regulation and dynamics, and how their integration into complex systems ...
openaire   +2 more sources

Motor‐Assisted Co‐Migration of Intracellular Organelles and Microtubules as a Mechanism for Directed Cargo Transport

BioEssays, Volume 48, Issue 3, March 2026.
Directional intracellular cargo transport is traditionally attributed to motor stepping along stationary microtubule (MT) tracks. We propose a complementary mechanism of cargo co‐migration with moving MTs. This mode requires cargo–MT tethering and directed MT motion.
Chuying Zhou, Mineko Kengaku
wiley   +1 more source

Intracellular interactions between APOBEC3G, RNA, and HIV-1 Gag: APOBEC3G multimerization is dependent on its association with RNA

Retrovirology, 2009
Background Host restriction factor APOBEC3G (A3G) blocks human immunodeficiency virus type 1 (HIV-1) replication by G-to-A hypermutation, and by inhibiting DNA synthesis and provirus formation.
Friew Yeshitila N, Boyko Vitaly, Hu Wei-Shau, Pathak Vinay K   +3 more
doaj   +1 more source

Heterogeneous Activated B Cell Compartments Arising Early and Transiently After SARS‐CoV‐2 Vaccination

European Journal of Immunology, Volume 56, Issue 3, March 2026.
Characterization of the early antigen‐specific B cell response post‐SARS‐CoV‐2 vaccination reveals novel activated B cell clusters, showing different phenotypes and contraction dynamics. Some short‐lived activated B cells expressed both CD71 and the extrafollicular marker CD11c.
Laura Fernandez Blanco, Lisan H. Kuijper, Laura Y.L. Kummer, Niels J.M. Verstegen, Amélie Bos, Mathieu Claireaux, Mariël C. Duurland, Tineke Jorritsma, Maurice Steenhuis, Gius Kerster, Juan J. Garcia Vallejo, Marit J. van Gils, Koos P.J. van Dam, Eileen W. Stalman, Luuk Wieske, Laura Boekel, Gertjan J. Wolbink, Sander W. Tas, Theo Rispens, Taco W. Kuijpers, Filip Eftimov, Anja ten Brinke, S. Marieke van Ham, of T2B! Immunity Against SARS‐CoV‐2 Study Group   +23 more
wiley   +1 more source

The structural and mechanistic bases for the viral resistance to allosteric HIV-1 integrase inhibitor pirmitegravir

mBio
Allosteric HIV-1 integrase (IN) inhibitors (ALLINIs) are investigational antiretroviral agents that potently impair virion maturation by inducing hyper-multimerization of IN and inhibiting its interaction with viral genomic RNA. The pyrrolopyridine-based
Tung Dinh, Zahira Tber, Juan S. Rey, Seema Mengshetti, Arun S. Annamalai, Reed Haney, Lorenzo Briganti, Franck Amblard, James R. Fuchs, Peter Cherepanov, Kyungjin Kim, Raymond F. Schinazi, Juan R. Perilla, Baek Kim, Mamuka Kvaratskhelia   +14 more
doaj   +1 more source

The hexamer structure of Rift Valley fever virus nucleoprotein suggests a mechanism for its assembly into ribonucleoprotein complexes.

PLoS Pathogens, 2011
Rift Valley fever virus (RVFV), a Phlebovirus with a genome consisting of three single-stranded RNA segments, is spread by infected mosquitoes and causes large viral outbreaks in Africa.
François Ferron, Zongli Li, Eric I Danek, Dahai Luo, Yeehwa Wong, Bruno Coutard, Violaine Lantez, Rémi Charrel, Bruno Canard, Thomas Walz, Julien Lescar   +10 more
doaj   +1 more source

How Does Biological Sex Impact Mucosal Bacterial Infection? Mucosal Defenses and Bacterial Detection

Immunological Reviews, Volume 338, Issue 1, March 2026.
ABSTRACT Urinary tract infections possess substantial sex disparities in the incidence, immune response, and progression of infection. Some of these distinctions may be due to sexual dimorphism in mucosal barriers or sex differences in the initial immune response to infection.
Laura Ramirez Finn, Molly A. Ingersoll
wiley   +1 more source

Critical domains for NACC2-NTRK2 fusion protein activation.

PLoS ONE
Neurotrophic receptor tyrosine kinases (NTRKs) belong to the receptor tyrosine kinase (RTK) family. NTRKs are responsible for the activation of multiple downstream signaling pathways that regulate cell growth, proliferation, differentiation, and ...
Wei Yang, April N Meyer, Zian Jiang, Xuan Jiang, Daniel J Donoghue   +4 more
doaj   +1 more source

IL40: A Newly Described Cytokine With Conflicting Measurements and Detection Variability—Are There Different Forms?

Scandinavian Journal of Immunology, Volume 103, Issue 3, March 2026.
IL40 has previously been reported to be elevated in rheumatic disease. Here we did not observe higher IL40 plasma levels in rheumatoid arthritis (RA) patients or ANCA‐associated vasculitis (AAV) patients compared to healthy donors and further found large discrepancies in IL40 measurements by two commercial ELISAs.
Nora Euler, Wenqi Huang, Peter Hemmingsson, Anna Juto, Erik Hellbacher, Lars Klareskog, Vivianne Malmström, Iva Gunnarsson, Eva Baecklund, Caroline Grönwall   +9 more
wiley   +1 more source

SMXL3 controls multiple aspects of Arabidopsis development via EAR motif‐dependent and ‐independent functions

The Plant Journal, Volume 125, Issue 5, March 2026.
SUMMARY SMAX1‐LIKE (SMXL) proteins, previously linked to strigolactone and karrikin signalling, play diverse and partially redundant roles in plant development. The divergent SMXL4 superclade—comprising SMXL3, SMXL4 and SMXL5—is not subject to strigolactone‐ or karrikin‐dependent proteolysis.
Zoltán Tolnai, Eszter Badics, Imran Khan, Martin Posta, Attila Fábián, Vilmos Soós   +5 more
wiley   +1 more source