Results 21 to 30 of about 30,129 (222)
Viruses, 2021 Apolipoprotein B mRNA editing catalytic polypeptide-like (APOBEC) proteins belong to a family of deaminase proteins that can catalyze the deamination of cytosine to uracil on single-stranded DNA or/and RNA.
Xiaojiang S. Chen
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Relationship between HIV-1 Gag Multimerization and Membrane Binding
Viruses, 2022 HIV-1 viral particle assembly occurs specifically at the plasma membrane and is driven primarily by the viral polyprotein Gag. Selective association of Gag with the plasma membrane is a key step in the viral assembly pathway, which is traditionally ...
Christopher Sumner, Akira Ono
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Cell Death and Disease, 2022 Transient receptor potential melastatin 8 (TRPM8) functions as a Ca2+-permeable channel in the plasma membrane (PM). Dysfunction of TRPM8 is associated with human pancreatic cancer and several other diseases in clinical patients, but the underlying ...
Yuan Huang +15 more
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A tyrosine residue on the TSH receptor stabilizes multimer formation. [PDF]
PLoS ONE, 2010 The thyrotropin stimulating hormone receptor (TSHR) is a G protein coupled receptor (GPCR) with a large ectodomain. The ligand, TSH, acting via this receptor regulates thyroid growth and thyroid hormone production and secretion.
Rauf Latif +3 more
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Blockade of the BAK hydrophobic groove by inhibitory phosphorylation regulates commitment to apoptosis. [PDF]
PLoS ONE, 2012 The BCL-2 family protein BAK is a key regulator of mitochondrial apoptosis. BAK activation first involves N-terminal conformational changes that lead to the transient exposure of the BAK BH3 domain that then inserts into a hydrophobic groove on another ...
Abul Azad +3 more
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Plant coilin: structural characteristics and RNA-binding properties. [PDF]
PLoS ONE, 2013 Cajal bodies (CBs) are dynamic subnuclear compartments involved in the biogenesis of ribonucleoproteins. Coilin is a major structural scaffolding protein necessary for CB formation, composition and activity.
Valentine Makarov +7 more
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eLife, 2021 Sterile alpha and toll/interleukin receptor (TIR) motif–containing protein 1 (SARM1) is a neuronally expressed NAD+ glycohydrolase whose activity is increased in response to stress.
Heather S Loring +6 more
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Stabilization of Multimeric Proteins via Intersubunit Cyclization [PDF]
Applied and Environmental Microbiology, 2017 ABSTRACT Proteins with high catalytic efficiency and selectivity under mild conditions have long been appreciated by industrial and medicinal fields. These proteins, which are commonly multimeric, often possess low stability, impeding wider application.
Lu Zhu +10 more
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Quantifying Asymmetry of Multimeric Proteins
The Journal of Physical Chemistry A, 2018 A large number of proteins assemble as homooligomers. These homooligomers accomplish their function either symmetrically or asymmetrically. If asymmetry is prevalent in a structure ensemble, the asymmetric motion will occur in any of the subunits. Many computational analysis tools implicitly use ensemble averages to determine protein motions, e.g ...
Julian T. Brennecke, Bert L. de Groot
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Mapping the binding interface between an HIV-1 inhibiting intrabody and the viral protein Rev. [PDF]
PLoS ONE, 2013 HIV-1 Rev is the key protein in the nucleocytoplasmic export and expression of the late viral mRNAs. An important aspect for its function is its ability to multimerize on these mRNAs.
Thomas Vercruysse +7 more
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