Results 31 to 40 of about 30,129 (222)
DNA-Mediated Stack Formation of Nanodiscs
Molecules, 2021 Membrane-scaffolding proteins (MSPs) derived from apolipoprotein A-1 have become a versatile tool in generating nano-sized discoidal membrane mimetics (nanodiscs) for membrane protein research.
Madhumalar Subramanian +4 more
doaj +1 more source
Adiponutrin: A multimeric plasma protein
Biochemical and Biophysical Research Communications, 2014 The interest in adiponutrin stems from adiponutrin variant I148M, which is strongly associated to non-alcoholic fatty liver disease. Adiponutrin has to date been considered to be solely an intracellular protein, with a role in lipid metabolism in liver and adipose tissue. However, a physiologically relevant role for adiponutrin has not been found.
Tinnerfelt Winberg, Martin +4 more
openaire +4 more sources
Retrovirology, 2008 Background The formation of new infectious human immunodeficiency type 1 virus (HIV-1) mainly relies on the homo-multimerization of the viral structural polyprotein Pr55Gag and on the recruitment of host factors.
Mouland Andrew J +3 more
doaj +1 more source
Analysis of the initiating events in HIV-1 particle assembly and genome packaging. [PDF]
PLoS Pathogens, 2010 HIV-1 Gag drives a number of events during the genesis of virions and is the only viral protein required for the assembly of virus-like particles in vitro and in cells.
Sebla B Kutluay, Paul D Bieniasz
doaj +1 more source
RL-MLZerD: Multimeric protein docking using reinforcement learning
Frontiers in Molecular Biosciences, 2022 Numerous biological processes in a cell are carried out by protein complexes. To understand the molecular mechanisms of such processes, it is crucial to know the quaternary structures of the complexes. Although the structures of protein complexes have been determined by biophysical experiments at a rapid pace, there are still many important complex ...
Tunde Aderinwale +3 more
openaire +3 more sources
Microbiology Spectrum, 2023 The capsid protein (CA), an essential component of human immunodeficiency virus type 1 (HIV-1), represents an appealing target for antivirals. Small molecules targeting the CAI-binding cavity in the C-terminal domain of HIV-1 CA (CA CTD) confer potent ...
Da-Wei Zhang +4 more
doaj +1 more source
FEBS Open Bio, 2014 Aquaporin-11 (AQP11) is the latest member of the mammalian water channel protein family to be described. Recent in vivo studies have shown that mutation at Cys227 causes renal failure.
Saki Takahashi +5 more
doaj +1 more source
Order Statistics Theory of Unfolding of Multimeric Proteins [PDF]
Biophysical Journal, 2010 Dynamic force spectroscopy has become indispensable for the exploration of the mechanical properties of proteins. In force-ramp experiments, performed by utilizing a time-dependent pulling force, the peak forces for unfolding transitions in a multimeric protein (D)(N) are used to map the free energy landscape for unfolding for a protein domain D.
Zhmurov, A., Dima, R.I., Barsegov, V.
openaire +2 more sources
The Evolution of Multimeric Protein Assemblages [PDF]
Molecular Biology and Evolution, 2011 Although the mechanisms by which complex cellular features evolve constitute one of the great unsolved problems of evolutionary biology, it is clear that the emergence of new protein-protein interactions, often accompanied by the diversification of duplicate genes, is involved.
openaire +2 more sources
Brighter Reporter Genes from Multimerized Fluorescent Proteins
BioTechniques, 2005 If low signal-to-noise ratios in GFP assays have you singing a sad tune, Genové et al. (p. 814) can offer a solution. Recognizing that GFP fluorescence can be almost undetectable when reporters are used downstream of relatively weak promoters or during detection in problematic tissues such as the CNS, the authors investigated whether tandem repeats of ...
Guillem Genové +2 more
openaire +3 more sources