Results 11 to 20 of about 17,355 (136)

Exploring the role of protein palmitoylation in cancer progression and therapy: a comprehensive bibliometric study (2004–2024) [PDF]

Discover Oncology
Objective This study aims to qualitatively and quantitatively assess the research landscape of palmitoylation in oncology using bibliometric analysis, thereby providing insights into research hotspots and emerging trends.
Yu Chen, Yuxuan Dai, Xing Wang, Jian Liu
doaj   +2 more sources

ZDHHC18‐Mediated Palmitoylation of ORF3a Promotes SARS‐CoV‐2 Pathogenesis by Antagonizing TRIM16‐Mediated Ubiquitination and Proteasomal Degradation

Advanced Science
SARS‐CoV‐2 accessory protein ORF3a contributes to viral pathogenesis through membrane remodeling, immune evasion, and inflammation induction. However, the molecular mechanisms underlying ORF3a‐mediated pathogenesis remain poorly characterized, and no ...
Sidi Yang, Kun Li, Lihong Liu, Linsen Zeng, Qifeng Deng, Jiacheng Huang, Xiaoran Dong, Xin Wang, Jianwei Liang, Hongchao Liu, Hong Peng, Yuxin Lin, Xiaolu Xie, Yuzhen Ye, Tiefeng Xu, Zhaohuan Wang, Chun‐Mei Li, Deyin Guo   +17 more
doaj   +2 more sources

Crosstalk of Synapsin1 palmitoylation and phosphorylation controls the dynamicity of synaptic vesicles in neurons

Cell Death and Disease, 2022
The dynamics of synaptic vesicles (SVs) within presynaptic domains are tightly controlled by synapsin1 phosphorylation; however, the mechanism underlying the anchoring of synapsin1 with F-actin or SVs is not yet fully understood. Here, we found that Syn1
Peipei Yan, Huicong Liu, Tao Zhou, Pu Sun, Yilin Wang, Xibin Wang, Lin Zhang, Tian Wang, Jing Dong, Jiangli Zhu, Luxian Lv, Wenqiang Li, Shiqian Qi, Yinming Liang, Eryan Kong   +14 more
doaj   +1 more source

Protein palmitoylation and cancer [PDF]

EMBO Reports, 2018
Scott Dixon
exaly   +2 more sources

Palmitoylation landscapes across human cancers reveal a role of palmitoylation in tumorigenesis

Journal of Translational Medicine, 2023
Background Protein palmitoylation, which is catalyzed by palmitoyl-transferase and de-palmitoyl-transferase, plays a crucial role in various biological processes. However, the landscape and dynamics of protein palmitoylation in human cancers are not well
Yue Kong, Yugeng Liu, Xianzhe Li, Menglan Rao, Dawei Li, Xiaolan Ruan, Shanglin Li, Zhenyou Jiang, Qiang Zhang   +8 more
doaj   +1 more source

S-Palmitoylation of Synaptic Proteins in Neuronal Plasticity in Normal and Pathological Brains

Cells, 2023
Protein lipidation is a common post-translational modification of proteins that plays an important role in human physiology and pathology. One form of protein lipidation, S-palmitoylation, involves the addition of a 16-carbon fatty acid (palmitate) onto ...
Anna Buszka, Agata Pytyś, Domnic Colvin, Jakub Włodarczyk, Tomasz Wójtowicz   +4 more
doaj   +1 more source

Malignant progression of liver cancer progenitors requires lysine acetyltransferase 7–acetylated and cytoplasm‐translocated G protein GαS

Hepatology, EarlyView., 2022
KAT7‐acetylated and cytoplasm‐translocated G‐protein GαS enhances IL‐6 effect and drives HCC progenitor cell progression. Abstract Background and Aims Hepatocarcinogenesis goes through HCC progenitor cells (HcPCs) to fully established HCC, and the mechanisms driving the development of HcPCs are still largely unknown.
Ye Zhou, Kaiwei Jia, Suyuan Wang, Zhenyang Li, Yunhui Li, Shan Lu, Yingyun Yang, Liyuan Zhang, Mu Wang, Yue Dong, Luxin Zhang, Wannian Zhang, Nan Li, Yizhi Yu, Xuetao Cao, Jin Hou   +15 more
wiley   +1 more source

Protein palmitoylation: Palmitoyltransferases and their specificity [PDF]

Experimental Biology and Medicine, 2017
Agnieszka Biernatowska, Aleksander Czogalla, Aleksander F Sikorski   +2 more
exaly   +2 more sources

PPT1 regulation of HSP90α depalmitoylation participates in the pathogenesis of hyperandrogenism

iScience, 2023
Summary: Ovarian granulosa cells (GCs) in the follicle are the important mediator of steroidogenesis and foster oocyte maturation. Evidences suggested that the function of GCs could be regulated by S-palmitoylation.
Tongmin Xue, Shanmeizi Zhao, Hong Zhang, Ting Tang, Lu Zheng, Jun Jing, Xie Ge, Rujun Ma, Jinzhao Ma, Xiaoyan Ren, Kadiliya Jueraitetibaike, Zhigang Guo, Li Chen, Bing Yao   +13 more
doaj   +1 more source

Function of Protein S-Palmitoylation in Immunity and Immune-Related Diseases

Frontiers in Immunology, 2021
Protein S-palmitoylation is a covalent and reversible lipid modification that specifically targets cysteine residues within many eukaryotic proteins. In mammalian cells, the ubiquitous palmitoyltransferases (PATs) and serine hydrolases, including acyl ...
Yuqi Zhang, Ziran Qin, Wenhuan Sun, Feng Chu, Fangfang Zhou   +4 more
doaj   +1 more source