Results 21 to 30 of about 3,365,420 (200)

Functional characterisation of the lipid raft protein stomatin [PDF]

, 2005
The function of the integral membrane protein stomatin is as yet poorly understood. Stomatin is deficient from the erythrocyte membrane of patients suffering with Overhydrated Hereditary Stomatocytosis (OHSt).
Wilkinson, Dorothy Kate
core   +7 more sources

Adipocyte-Derived Palmitic Acid Promotes Breast Cancer Malignancy via ZDHHC15-Mediated S-Palmitoylation of PPARγ. [PDF]

Cancer Sci
Adipocyte‐derived palmitic acid induces ZDHHC15‐mediated PPARγ S‐palmitoylation at Cys159, triggering its proteasomal degradation and promoting breast cancer malignancy with rosiglitazone resistance. Inhibition of PPARγ S‐palmitoylation by 2‐bromopalmitate suppresses breast cancer progression and synergistically enhances rosiglitazone efficacy ...
Moon GH, Lee MY, Koh J, Hong KY, Fukuda J, Kim SJ, Chun YS.   +6 more
europepmc   +2 more sources

The on-off story of protein palmitoylation

Trends in Cell Biology, 2003
Palmitoylation is one of the most frequent post-translational modifications found on proteins. It contributes to membrane association, protein sorting and many other processes.
Marsh, M, Bijlmakers, M J
core   +4 more sources

Crosstalk of Synapsin1 palmitoylation and phosphorylation controls the dynamicity of synaptic vesicles in neurons

Cell Death and Disease, 2022
The dynamics of synaptic vesicles (SVs) within presynaptic domains are tightly controlled by synapsin1 phosphorylation; however, the mechanism underlying the anchoring of synapsin1 with F-actin or SVs is not yet fully understood. Here, we found that Syn1
Peipei Yan, Huicong Liu, Tao Zhou, Pu Sun, Yilin Wang, Xibin Wang, Lin Zhang, Tian Wang, Jing Dong, Jiangli Zhu, Luxian Lv, Wenqiang Li, Shiqian Qi, Yinming Liang, Eryan Kong   +14 more
doaj   +1 more source

On the mechanism of protein palmitoylation [PDF]

The EMBO Reports, 2004
Protein palmitoylation or, more specifically, S-acylation is a reversible post-translational lipid modification. Despite the identification of several proteins that are altered in this way, our understanding of the enzymology of this process has been hampered by the lack of well-characterized acyltransferases.
Lars E P, Dietrich, Christian, Ungermann
openaire   +2 more sources

Altered Protein Palmitoylation as Disease Mechanism in Neurodegenerative Disorders. [PDF]

J Neurosci
Palmitoylation, a lipid-based posttranslational protein modification, plays a crucial role in regulating various aspects of neuronal function through altering protein membrane-targeting, stabilities, and protein-protein interaction profiles.
Wlodarczyk J, Bhattacharyya R, Dore K, Ho GPH, Martin DDO, Mejias R, Hochrainer K.   +6 more
europepmc   +3 more sources

Palmitoylation landscapes across human cancers reveal a role of palmitoylation in tumorigenesis

Journal of Translational Medicine, 2023
Background Protein palmitoylation, which is catalyzed by palmitoyl-transferase and de-palmitoyl-transferase, plays a crucial role in various biological processes. However, the landscape and dynamics of protein palmitoylation in human cancers are not well
Yue Kong, Yugeng Liu, Xianzhe Li, Menglan Rao, Dawei Li, Xiaolan Ruan, Shanglin Li, Zhenyou Jiang, Qiang Zhang   +8 more
doaj   +1 more source

Malignant progression of liver cancer progenitors requires lysine acetyltransferase 7–acetylated and cytoplasm‐translocated G protein GαS

Hepatology, EarlyView., 2022
KAT7‐acetylated and cytoplasm‐translocated G‐protein GαS enhances IL‐6 effect and drives HCC progenitor cell progression. Abstract Background and Aims Hepatocarcinogenesis goes through HCC progenitor cells (HcPCs) to fully established HCC, and the mechanisms driving the development of HcPCs are still largely unknown.
Ye Zhou, Kaiwei Jia, Suyuan Wang, Zhenyang Li, Yunhui Li, Shan Lu, Yingyun Yang, Liyuan Zhang, Mu Wang, Yue Dong, Luxin Zhang, Wannian Zhang, Nan Li, Yizhi Yu, Xuetao Cao, Jin Hou   +15 more
wiley   +1 more source

Palmitoylation of Hedgehog Proteins [PDF]

, 2012
Hedgehog (Hh) proteins are secreted signaling proteins that contain amide-linked palmitate at the N-terminus and cholesterol at the C-terminus. Palmitoylation of Hh proteins is critical for effective long- and short-range signaling. The palmitoylation reaction occurs during transit of Hh through the secretory pathway, most likely in the lumen of the ER.
John A, Buglino, Marilyn D, Resh
openaire   +2 more sources

Palmitoylated proteins in Ureaplasma urealyticum [PDF]

Infection and Immunity, 1991
After incubation of Ureaplasma urealyticum serotype 8 in the presence of 3H-labeled palmitic acid, about 25 acylated proteins were detected by electrophoresis and fluorography. Of these, at least six were shown to be antigenic by immunoprecipitation of solubilized palmitate-labeled cells with a homologous polyclonal serum.
D, Thirkell, A D, Myles, W C, Russell
openaire   +2 more sources