Results 171 to 180 of about 1,442,861 (307)
Estudos de inibição de proteínas tirosina fosfatases de Mycobacterium tuberculosis e Yersinia enterocolitica, e caracterização de uma proteína serina/treonina fosfatase de Mycoplasma synoviae [PDF]
, 2014 A fosforilação reversível de proteínas mediada por proteínas cinases e fosfatases tem uma função reguladora central em muitos processos celulares em eucariotos e procariotos. Especialmente, proteínas tirosina fosfatases (PTPs), que constituem uma família
Menegatti, Angela Camila Orbem
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Advanced Science, EarlyView.In a lumbar spine instability model, dorsal root ganglion cells mediate the perception of relevant mechanical stresses through Piezo2 and subsequently release CGRP. CGRP activates the NF‐κB signaling pathway in cartilage endplate cells through the receptor RAMP1.
Hanpeng Xu +16 more
wiley +1 more source
Protein tyrosine phosphatase SHP2 suppressespodosome rosette formation in Src-transformedfibroblasts
, 2014 Podosomes are actin-enriched membrane protrusions that play important roles in extracellular matrix degradation and invasive cell motility. Podosomes undergo self-assembly into large rosette-like structures in Src-transformed fibroblasts, osteoclasts and
Hong-Chen Chen +4 more
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Advanced Science, EarlyView.IL‐15‐engineered stem cell–NK cell complexes, assembled via bioorthogonal chemistry, enable effective lung cancer immunotherapy. Abstract Natural killer (NK) cells represent a powerful immunotherapeutic strategy due to their intrinsic cytotoxicity and ability to target tumor cells independently of antigen presentation.
Qian Zhang +15 more
wiley +1 more source
SARP2 como marcador molecular de morfologia de espermatozóides humanos
, 2011 Mestrado em Biologia Aplicada - Biologia Molecular e CelularA fosforilação proteica resulta de um equilíbrio entre fosfatases e quinases constituindo o principal regulador da maioria dos mecanismos existentes nos sistemas biológicos.
Santos, Nadine Castelhano
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Filament structure and phosphatase activity in the Rivulariaceae [PDF]
, 1989 A study was carried out on phosphatase activity, phosphate uptake and its relationship to hair formation in the Rivulariaceae. The Rivulariaceae was chosen as it is a widespread taxon, where hair formation is a common occurrence, and previous studies ...
Grainger, Stewart L.J.
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A Bifunctional T3SS‐Effector Simultaneously Cleaves Host MAP Kinase and Inhibits PPM1A Phosphatase
Advanced Science, EarlyView.Pathogenic bacteria exploit the metalloprotease effector NleD to subvert host defenses. Structural, biochemical, and infection analyses reveal a bifunctional mechanism by which NleD binds and inhibits the host phosphatase PPM1A while preserving its proteolytic activity against MAPKs.
Yaakov Socol +18 more
wiley +1 more source
Advanced Science, EarlyView.Perivascular matrix densification promotes the emergence of aberrant endothelial tip cells (ATECs) that invade and persist within fibrotic microenvironments. Using in vivo lineage tracing and a human microvessel model, this study shows that fibrous matrix cues destabilize VE‐cadherin–mediated junctions to gate TGF‐β signaling, inducing a pro ...
Jingyi Xia +17 more
wiley +1 more source
, 2008 We define phosphovariants as genetic variations that change phosphorylation sites or their interacting kinases. Considering the essential role of phosphorylation in protein functions, it is highly likely that phosphovariants change protein functions and ...
Pamela Song +4 more
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