Results 191 to 200 of about 1,442,861 (307)

Dual-specificity protein phosphatase 1: A potential therapeutic target in cancer. [PDF]

iScience
Niture S, Mooers BHM, Wu DH, Hart M, Jaboin J, Seneviratne D.   +5 more
europepmc   +1 more source

Unraveling the Molecular Mechanisms Underlying Spontaneous Multipolar Mitosis Through CIN‐seq

Advanced Science, EarlyView.
Multipolar mitosis, a hallmark of chromosomal instability (CIN), drives tumor heterogeneity but is challenging to study in live cells. Using CIN‐seq, a single‐cell multiomics method, we profiled rare CIN events and identified mechanisms associated with viable multipolar mitosis, including PTEN attenuation, Rho GTPase‐driven cytokinesis failure, and ...
Pin‐Rui Su, Ting‐Chun Chou, Maria Teresa López‐Cascales, Junfeng Huang, Tsai‐Ying Chen, Sjoukje van Wieren, Chan Li, Cecile Beerens, Li You, Jelle Storteboom, Miao‐Ping Chien   +10 more
wiley   +1 more source

Protein phosphatase 2Cδ/Wip1 regulates phospho-p90RSK2 activity in lesional psoriatic skin

, 2017
Mads K Rasmussen, Jakob Nielsen, Rasmus B Kjellerup, Stine M Andersen, Anne H Rittig, Claus Johansen, Lars Iversen, Borbala Gesser Department of Dermatology, Aarhus University Hospital, Aarhus, Denmark Objectives: P90 ...
Rittig AH, Kjellerup RB, Andersen SM, Gesser B, Johansen C, Rasmussen MK, Nielsen J, Iversen L   +7 more
core  

Exploring the feasibility of protein phosphatase 1-docking motif-mimetic cell-penetrating peptides for modulating prostate carcinogenesis. [PDF]

JNCI Cancer Spectr
Rodrigues RM, Felgueiras J, Jones S, Camilo V, Matos B, Jerónimo C, Howl J, Fardilha M.   +7 more
europepmc   +1 more source

Dysregulated expression of slingshot protein phosphatase 1 (SSH1) disrupts circadian rhythm and WNT signaling associated to hepatocellular carcinoma pathogenesis. [PDF]

Aging (Albany NY), 2023
Lai SW, Cheng YC, Huang WC, Yadav VK, Fong IH, Yeh CT, Yang CK, Lee WH, Chen MY.   +8 more
europepmc   +1 more source

Electroacupuncture Improves the Learning and Memory by Modulating Hippocampal Glucose Metabolism through IGF1/IGF1R Signaling in Alzheimer's Disease

Advanced Science, EarlyView.
Electroacupuncture (EA) ameliorates learning and memory function in 5×FAD mice by regulating the brain glucose metabolic network. This neuroprotective effect is closely related to enhancing neuronal energy utilization via the IGF1/IGF1R signaling pathway.
Shengxiang Liang, Qingqing Zhang, Xiuxiu Wang, Lixin Peng, Xinru Ji, Jiawei Wang, Yusi Zhang, Jiayang Huang, Junchao Yang, Shiqi Zhan, Yiping Xiao, Weilin Liu, Lidian Chen   +12 more
wiley   +1 more source

Characterization of the Regulatory AAA-ATPase Subunit Rpt3 in <i>Plasmodium berghei</i> as an Activator of Protein Phosphatase 1. [PDF]

Int J Mol Sci
Lainé C, De Witte C, Martoriati A, Farce A, Metatla I, Guerrera IC, Cailliau K, Khalife J, Pierrot C.   +8 more
europepmc   +1 more source

Knockout of protein phosphatase 1 in Leishmania major reveals its role during RNA polymerase II transcription termination. [PDF]

Nucleic Acids Res, 2023
Kieft R, Zhang Y, Yan H, Schmitz RJ, Sabatini R.   +4 more
europepmc   +1 more source

Gut Mycobiota‐Associated Tryptophan Catabolites Protect Against Metabolic Dysfunction‐Associated Steatotic Liver Disease

Advanced Science, EarlyView.
ABSTRACT Accumulating evidence suggests that the intestinal microbiota participates in the progression of metabolic dysfunction‐associated steatotic liver disease (MASLD) through microbiota‐host interaction. However, the beneficial role of commensal mycobiota in MASLD progression remains poorly understood.
Shuping Qiao, Shuangya Fan, Juan Xu, Zhen Xu, Chen Peng, Junxing Qu, Ziqian Bing, Shizhen Zhou, Sunan Shen, Guifang Xu, Yue Zhao, Tingting Wang   +11 more
wiley   +1 more source

Alphaherpesvirus pUL21 homologs use non-canonical sequences to compete with cellular adaptors for protein phosphatase 1 binding. [PDF]

J Biol Chem
Monkhouse H, Carter-Lopez DS, Benedyk TH, Deane JE, Graham SC.   +4 more
europepmc   +1 more source