Results 261 to 270 of about 1,444,803 (306)

Lilrb4a Suppression Reprograms Microglia to Mitigate APOE4‐Associated Amyloid Plaques and Cerebral Amyloid Angiopathy in Association With a PPAR‐Linked Pro‐Clearance State

Advanced Science, EarlyView.
Targeting Lilrb4a in Apolipoprotein E4 (APOE4)‐associated Alzheimer's disease (AD) reprograms microglia toward a beneficial, phagocytic state. Genetic deletion or antisense inhibition of Lilrb4a suppresses p‐SHP2/NF‐κB/STAT1 signaling, restores PPAR‐linked lipid and energy metabolism, and reduces amyloid plaque burden and cerebral amyloid angiopathy ...
Changxu Nie, Ruixi Yang, Xiaotong Wang, Ping Jia, Xueqi Zhang, Yaqi Dai, Xue Bai, Sijia Duan, Yufeng Li, Peng Zheng, Xin Tian, Li Jiang, Chao Wang   +12 more
wiley   +1 more source

Thermochemical Micro‐Explosion for Prompt Thrombolysis via Proximal Injection of Liquid Alkali Metal

Advanced Science, EarlyView.
We report a micro‐explosive thermochemical thrombolysis (METCT) therapy via injectable liquid alkali metal encapsulated in dimethyl silicone (LAM@oil). METCT enables prompt and safe vascular recanalization within 90 s. Critically, the LAM@oil system demonstrates significantly higher thrombolytic efficacy compared to clinically available thrombolytic ...
Xin Liao, Yi Hou, Jie Zhang, Bo Wang, Minghui Guo, Hua Qu, Wei Rao, Jing Liu   +7 more
wiley   +1 more source

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Protein phosphatase-1 and insulin action

Molecular and Cellular Biochemistry, 1998
Protein Phosphatase-1 (PP-1) appears to be the key component of the insulin signalling pathway which is responsible for bridging the initial insulin-simulated phosphorylation cascade with the ultimate dephosphorylation of insulin sensitive substrates.
L, Ragolia, N, Begum
openaire   +2 more sources

Tautomycin’s Interactions with Protein Phosphatase 1

Chemistry – An Asian Journal, 2010
AbstractIt has been a long journey since tautomycin (TTM) was isolated in 1987 and the discovery that it inhibited protein phosphatase 1 (PP1) more strongly than PP2A until finally the cocrystal structure of TTM and PP1 was presented early in 2009. The fact that TTM shows preference to inhibit PP1 over PP2A makes this compound unique among the known ...
Magne O, Sydnes, Minoru, Isobe
openaire   +2 more sources

Protein phosphatase 1 dephosphorylates Orc2

Biochemical and Biophysical Research Communications, 2014
Phosphorylation of Thr(116) and Thr(226) on Orc2, one of the six subunits of the origin recognition complex (ORC), by cyclin A/CDK2 during S phase leads to the dissociation of Orc2, Orc3, Orc4, and Orc5 subunits (Orc2-5) from human chromatin and replication origins. The phosphorylated Orc2 becomes dephosphorylated in the late M phase of the cell cycle.
Kyung Yong, Lee, June Sung, Bae, Gwang Su, Kim, Deog Su, Hwang   +3 more
openaire   +2 more sources

Protein phosphatase 1

2003
Protein phosphatase 1 (PP1) is one of the first protein phosphatases whose activity was detected and whose catalytic subunit (PP1c) was purified and cloned. It is the representative of the most ancient protein phosphatase family that has a ubiquitous distribution in all eukaryotic organisms. The high level of conservation of the amino acid sequence and
Viktor Dombrádi, Endre Kókai, Ilona Farkas   +2 more
openaire   +1 more source

Phosphoprotein Inhibitors of Protein Phosphatase-1

2003
Publisher Summary The chapter discusses phosphoprotein inhibitors of protein phosphatase-1(PP1). Over 25 years ago, a search for proteins that could regulate phosphorylase phosphatase yielded heat-stable proteins that were called “inhibitor-1” (I-1) and “inhibitor-2” (I-2).
Masumi, Eto, Craig, Leach, Nikolaos A, Tountas, David L, Brautigan   +3 more
openaire   +2 more sources

Assay of Protein Phosphatase 1 Complexes

2003
Publisher Summary This chapter provides an overview on assay of Protein phosphatase 1 (PP1) complexes. PP1 catalyzes the dephosphorylation of serine and threonine residues in proteins at neutral pH. The PP1 catalytic subunit is a member of the PPP family of protein phosphatases, and found in complex form, compared to a variety of different regulatory
Patricia T, Cohen, Gareth J, Browne, Mirela, Delibegovic, Shonagh, Munro   +3 more
openaire   +2 more sources

Validation of Interactions with Protein Phosphatase-1

2003
Publisher Summary This chapter presents an overview of the techniques that are available to study the interaction of protein phosphatase 1 (PP1) with other proteins. Most interactors of PP1 are inhibitors of the phosphorylase phosphatase activity of the catalytic subunit.
Aleyde, Van Eynde, Mathieu, Bollen
openaire   +2 more sources