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Carcinogenic Aspects of Protein Phosphatase 1 and 2A Inhibitors
2009Okadaic acid is functionally a potent tumor promoter working through inhibition of protein phosphatases 1 and 2A (PP1 and PP2A), resulting in sustained phosphorylation of proteins in cells. The mechanism of tumor promotion with okadaic acid is thus completely different from that of the classic tumor promoter phorbol ester.
Hirota, Fujiki, Masami, Suganuma
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[Advances of protein phosphatase-1--a review].
Wei sheng wu xue bao = Acta microbiologica Sinica, 2009Protein phosphatase-1 (PP1) is a member of the Ser/Thr phosphatases and widely distributed in many organisms. The enzyme regulates many important physiological processes, including gene transcription, translation, metabolism, cell growth and division.
Baijing, Wang, Xiujie, Xie, Qun, Wei
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PTEN Dual Lipid- and Protein-Phosphatase Function in Tumor Progression
Cancers, 2022Glenn Merlino, Yanlin Yu, Yu Yanlin
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Molecular basis for TPR domain-mediated regulation of protein phosphatase 5
EMBO Journal, 2005David Barford +2 more
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Rearrangement of the Protein Phosphatase 1 Interactome During Heart Failure Progression
Circulation, 2018Xander Wehrens +2 more
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Systematic Analysis of Human Protein Phosphatase Interactions and Dynamics
Cell Systems, 2017Markku Varjosalo +2 more
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Development of a Peptide that Selectively Activates Protein Phosphatase‐1 in Living Cells
Angewandte Chemie - International Edition, 2012Junbin Qian, Maja Köhn, Darren Hart
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