Results 111 to 120 of about 4,239,129 (300)

Activation of Protein Phosphatase 2A by the Fe2+/Ascorbate System [PDF]

Journal of Biochemistry, 1998
Freshly isolated protein phosphatase 2A (PP2A) was highly active as to the dephosphorylation of protein substrates, but lost most of its spontaneous activity on prolonged storage, and was converted to a latent form requiring Mn2+ or Co2+ ions for activity.
openaire   +2 more sources

Self‐Healing Hydrogel‐Enabled Modular Assembly of Bilayered Skin Construct for Hair Follicle Regeneration

Advanced Healthcare Materials, EarlyView.
Self‐healing assembly of two cell‐laden hydrogel layers creates a biomimetic skin construct that restores both dermal and epidermal functions, resulting in accelerated wound healing and enhanced hair follicle regeneration in a full‐thickness skin wound model. ABSTRACT Alopecia remains a pervasive clinical challenge, largely owing to the limited ability
JaeWook Park, Su Yong Kim, MinSu Jeong, Beom Joon Kim, Shin Hyuk Kang, Won‐Gun Koh   +5 more
wiley   +1 more source

Protein phosphatase 2A modulates podocyte maturation and glomerular functional integrity in mice

Cell Communication and Signaling, 2019
Background Protein phosphorylation & dephosphorylation are ubiquitous cellular processes that allow for the nuanced and reversible regulation of protein activity.
Xiujuan Zhu, Yuhong Ye, Chengxian Xu, Cunji Gao, Yingying Zhang, Jing Zhou, Weiqiang Lin, Jianhua Mao   +7 more
doaj   +1 more source

Atom‐Efficient Cerium‐Based Molecular Cages as Biocompatible Reactive Oxygen Scavengers

Advanced Healthcare Materials, EarlyView.
Discrete mixed‐valent cerium molecular cages organize accessible redox centers within confined coordination environments and scavenge superoxide, hydrogen peroxide, and hydroxyl radicals. Encapsulation of the lead cage in an ROS‐responsive DTP nanoplatform enables lesion‐associated delivery, attenuates macrophage oxidative stress and inflammation, and ...
Chao Li, Chunbai Xiang, Ye Xu, Yu Liu, Keze Hong, Fanchu Zeng, Gelin Xu, Zhao‐Xi Wang, Jonathan L. Sessler, Ping Gong   +9 more
wiley   +1 more source

Histone chaperone NAP1 mediates sister chromatid resolution by counteracting protein phosphatase 2A.

PLoS Genetics, 2013
Chromosome duplication and transmission into daughter cells requires the precisely orchestrated binding and release of cohesin. We found that the Drosophila histone chaperone NAP1 is required for cohesin release and sister chromatid resolution during ...
Yuri M Moshkin, Cecile M Doyen, Tsung-Wai Kan, Gillian E Chalkley, Karen Sap, Karel Bezstarosti, Jeroen A Demmers, Zeliha Ozgur, Wilfred F J van Ijcken, C Peter Verrijzer   +9 more
doaj   +1 more source

Anhydride modified cantharidin analogues. Is ring opening important in the inhibition of protein phosphatase 2A?

, 2000
A series of anhydride modified cantharidin analogues have been synthesised and screened for their ability to inhibit protein phosphatase 2A. Surprisingly only analogues capable of undergoing a facile ring opening of the anhydride moiety displayed any ...
Mirella A. Keane, McCluskey, A, Ronald J. Quinn, Quinn, RJ, Adam McCluskey, Jennette Sakoff, Alistair T.R. Sim, Mudgee, LM, Sakoff, J, Lisa-Maree Mudgee, Keane, MA, Sim, ATR   +11 more
core   +1 more source

Hybrid Biofabrication of a Hierarchically Organized Periosteum‐Inspired In Vitro Platform

Advanced Healthcare Materials, EarlyView.
A hybrid biofabrication strategy integrates melt electrowriting with extrusion‐based 3D bioprinting to create a hierarchically organized periosteum‐inspired in vitro platform. Spatially defined osteogenic, fibrous, and endothelial cell‐containing compartments support long‐term culture, osteogenic maturation, and CD31+ endothelial cell organization ...
Yakui Liu, Xinggui Tian, Anne Bernhardt, Anja Lode, Max von Witzleben, Ege Kirbas, Stefan Zwingenberger, Michael Gelinsky   +7 more
wiley   +1 more source

Roles of Phosphotase 2A in Nociceptive Signal Processing

Molecular Pain, 2013
Multiple protein kinases affect the responses of dorsal horn neurons through phosphorylation of synaptic receptors and proteins involved in intracellular signal transduction pathways, and the consequences of this modulation may be spinal central ...
Yun Wang, Yongzhong Lei, Li Fang, Yonggao Mu, Jing Wu, Xuan Zhang   +5 more
doaj   +1 more source

Bone Organoids Across the Development‐to‐Remodeling Continuum: From Tissue Formation to Functional Competence and Translation

Advanced Healthcare Materials, EarlyView.
Mineralization alone does not establish a mature bone organoid. This Review integrates biological foundations, materials design, adaptive remodeling, and translational validation through the development‐to‐remodeling continuum (DRC). By separating biological functions from the evidence supporting them, the framework exposes critical gaps in current ...
Xijie Tang, Haijia Xu, Xiangzhong Liu, Yi Yang, Zhanghua Li   +4 more
wiley   +1 more source

PROTEIN PHOSPHATASE 2A (PP2A) AS A THERAPEUTIC TARGET IN ACUTE MYELOID LEUKEMIA

Frontiers in Oncology, 2016
Acute myeloid leukemia (AML) is a heterogeneous malignant disorder of hematopoietic progenitor cells in which several genetic and epigenetic aberrations have been described.
Elena eArriazu, Raffaella ePippa, Maria D Odero   +2 more
doaj   +1 more source