Results 21 to 30 of about 573,078 (335)

Monotherapy efficacy of blood–brain barrier permeable small molecule reactivators of protein phosphatase 2A in glioblastoma

Brain Communications, 2020
Glioblastoma is a fatal disease in which most targeted therapies have clinically failed. However, pharmacological reactivation of tumour suppressors has not been thoroughly studied as yet as a glioblastoma therapeutic strategy.
J. Merisaari, Oxana V. Denisova, M. Doroszko, V. Le Joncour, Patrik Johansson, W. Leenders, David B. Kastrinsky, Nilesh Zaware, G. Narla, P. Laakkonen, S. Nelander, M. Ohlmeyer, J. Westermarck   +12 more
semanticscholar   +1 more source

ULK1 phosphorylation of striatin activates protein phosphatase 2A and autophagy

Cell Reports, 2021
Summary: The evolutionarily conserved ULK1 kinase complex acts as gatekeeper of canonical autophagy and regulates induction of autophagosome biogenesis.
Zehan Hu, Devanarayanan Siva Sankar, Bich Vu, Alexandre Leytens, Christine Vionnet, Wenxian Wu, Michael Stumpe, Esther Martínez-Martínez, Björn Stork, Jörn Dengjel   +9 more
doaj   +1 more source

The Cell-Cycle Regulatory Protein p21CIP1/WAF1 Is Required for Cytolethal Distending Toxin (Cdt)-Induced Apoptosis. [PDF]

, 2020
The Aggregatibacter actinomycetemcomitans cytolethal distending toxin (Cdt) induces lymphocytes to undergo cell-cycle arrest and apoptosis; toxicity is dependent upon the active Cdt subunit, CdtB.
Boesze-Battaglia, Kathleen, Shenker, Bruce J, Walker, Lisa M, Weiss, Robert H, Zekavat, Ali   +4 more
core   +2 more sources

Cancerous inhibitor of protein phosphatase 2A determines bortezomib-induced apoptosis in leukemia cells

Haematologica, 2013
The multiple cellular targets affected by proteasome inhibition implicate a potential role for bortezomib, a first-in-class proteasome inhibitor, in enhancing antitumor activities in hematologic malignancies.
Chun-Yu Liu, Chung-Wai Shiau, Hsin-Yu Kuo, Hsiang-Po Huang, Ming-Huang Chen, Cheng-Hwai Tzeng, Kuen-Feng Chen   +6 more
doaj   +1 more source

Hyperglycemia triggers HIPK2 protein degradation [PDF]

, 2016
Homeodomain interacting protein kinase-2 (HIPK2) is an evolutionary conserved kinase that modulates several key molecular pathways to restrain tumor growth and induce p53-depending apoptotic cell-death in response to anticancer therapies. HIPK2 silencing
Baldari, Silvia, Cirone, Mara, Cuomo, Laura, D'Orazi, Gabriella, Garufi, Alessia, Granato, Marisa, Pistritto, Giuseppa   +6 more
core   +2 more sources

Protein phosphatase beta, a putative type-2A protein phosphatase from the human malaria parasite Plasmodium falciparum. [PDF]

, 1997
Protein phosphatases play a critical role in the regulation of the eukaryotic cell cycle and signal transduction. A putative protein serine/threonine phosphatase gene has been isolated from the human malaria parasite Plasmodium falciparum.
Arndt K. T., Barton G. J., Bruce M. C., Chen J., Chen J., Day K. P., Favre B., Kamibayashi C., Kennelly P. I., Lee J., Li I. L., Lin F. C., Lorca T., Nussenzweig R. S., Pallas D. C., Posas F., Rangachari K., Read L. K., Ronne H., Ross-MacDonald P. B., Shima H., Snaith H. A., Sneddon A. A., Stone S. R., Sutton A., Wera S., Xie H., Zhang Z., Zhang Z., Zhao Y., Zhao Y., Zhuo S., Zolnierowicz S.   +32 more
core   +1 more source

The structural requirements for ceramide activation of serine-threonine protein phosphatases

Journal of Lipid Research, 2004
The protein phosphatases1 (PP1) and 2A (PP2A) serve as ceramide-activated protein phosphatases (CAPP). In this study, the structural requirements for interaction between ceramide and CAPP were determined.
Charles E. Chalfant, Zdzislaw Szulc, Patrick Roddy, Alicja Bielawska, Yusuf A. Hannun   +4 more
doaj   +1 more source

MicroRNA exporter HuR clears the internalized pathogens by promoting pro‐inflammatory response in infected macrophages

EMBO Molecular Medicine, 2020
HuR is a miRNA derepressor protein that can act as miRNA sponge for specific miRNAs to negate their action on target mRNAs. Here we have identified how HuR, by inducing extracellular vesicles‐mediated export of miRNAs, ensures robust derepression of ...
Avijit Goswami, Kamalika Mukherjee, Anup Mazumder, Satarupa Ganguly, Ishita Mukherjee, Saikat Chakrabarti, Syamal Roy, Shyam Sundar, Krishnananda Chattopadhyay, Suvendra N Bhattacharyya   +9 more
doaj   +1 more source

Novel prokaryotic expression of thioredoxin-fused insulinoma associated protein tyrosine phosphatase 2 (IA-2), its characterization and immunodiagnostic application [PDF]

, 2016
Background The insulinoma associated protein tyrosine phosphatase 2 (IA-2) is one of the immunodominant autoantigens involved in the autoimmune attack to the beta-cell in Type 1 Diabetes Mellitus.
A Trabucchi, A Trabucchi, A Trabucchi, A Villalba, A Villalba, A Westerlund-Karlsson, Adriana Victoria Sabljic, AG Krochik, AL Notkins, Aldana Trabucchi, BD Spangler, Bruno David Rovitto, C Levy-Marchal, C Tiberti, C Torn, CA Baer, CC Richardson, CF Verge, D Barford, DU Rabin, DU Rabin, E Bonifacio, E Bonifacio, E Kawasaki, EA Gale, Edgardo Poskus, ELD Harlow, ER LaVallie, ER LaVallie, ET Mambetisaeva, Expert Committee on the Diagnosis and Classification of Diabetes Mellitus, F Baneyx, F Sodoyez-Goffaux, G Hannig, GS Eisenbarth, H Goetz, H Mziaut, H Mziaut, H Shägger, H Xie, I Kikkas, J Sambrook, J Seissler, J Suckale, JA Berzofsky, JA Berzofsky, JA Dromey, JC Sodoyez, JM Gonzalez-Buitrago, JM Wenzlau, JP Palmer, K Lobner, KT Elvers, L Castano, LL Guerra, Luciano Lucas Guerra, M Hawa, M Knip, M Masuda, M Solimena, M Trajkovski, M Trajkovski, MA Payton, ML Papouchado, ML Papouchado, MP Sica, MS Lan, MS Lan, Natalia Inés Faccinetti, NG Morgenthaler, O Pines, P Tompa, PD Burbelo, PJ Bingley, PZ Zimmet, R Gianani, R Turner, RD Hoffman, RR Stumpo, Ruben Francisco Iacono, S Chen, S Krause, S Schubert, S Torii, Silvina Noemí Valdez, SJ Kim, SLBP Thrower, SN Valdez, SN Valdez, T Ort, T Tuomi, VN Uversky, WA Hagopian, X Jia, X Palomer, Z Zhao   +95 more
core   +5 more sources

Memantine Attenuates Alzheimer's Disease-Like Pathology and Cognitive Impairment.

PLoS ONE, 2015
Deficiency of protein phosphatase-2A is a key event in Alzheimer's disease. An endogenous inhibitor of protein phosphatase-2A, inhibitor-1, I1PP2A, which inhibits the phosphatase activity by interacting with its catalytic subunit protein phosphatase-2Ac,
Xiaochuan Wang, Julie Blanchard, Inge Grundke-Iqbal, Khalid Iqbal   +3 more
doaj   +1 more source