Results 31 to 40 of about 573,078 (335)

Structure of the Protein Phosphatase 2A Holoenzyme [PDF]

Cell, 2006
Protein Phosphatase 2A (PP2A) plays an essential role in many aspects of cellular physiology. The PP2A holoenzyme consists of a heterodimeric core enzyme, which comprises a scaffolding subunit and a catalytic subunit, and a variable regulatory subunit.
Yanhui Xu, Y. Xing, Yu Chen, Y. Chao, Zheng Lin, Eugene Fan, Jong W. Yu, S. Strack, P. Jeffrey, Yigong Shi   +9 more
semanticscholar   +3 more sources

The glucocorticoid-Angptl4-ceramide axis induces insulin resistance through PP2A and PKCζ. [PDF]

, 2017
Chronic glucocorticoid exposure is associated with the development of insulin resistance. We showed that glucocorticoid-induced insulin resistance was attenuated upon ablation of Angptl4, a glucocorticoid target gene encoding the secreted protein ...
Benjamin, Daniel I, Chen, Tzu-Chieh, Costello, Damian E, Kuo, Taiyi, Lee, Rebecca A, Li, Mei-Lan, Mar, Darryl J, Nomura, Daniel K, Wang, Jen-Chywan   +8 more
core   +1 more source

Purification and characterization of a protein inhibitor from rat liver that inhibits type 1 protein phosphatase when 3-hydroxy-3-methylglutaryl CoA reductase is the substrate.

Journal of Lipid Research, 1990
A protein inhibitor of HMG-CoA reductase phosphatase activity from rat liver was purified to homogeneity. The protein was purified 4,000-fold with an overall yield of 4%. The purified protein had a molecular mass of 31 kDa.
D Serra, G Asins, FG Hegardt
doaj   +1 more source

Protein phosphatase 2A stimulates activation of TFEB and TFE3 transcription factors in response to oxidative stress

Journal of Biological Chemistry, 2018
Adaptations and responses to stress conditions are fundamental processes that all cells must accomplish to maintain or restore cellular homeostasis. Cells have a plethora of response pathways to mitigate the effect of different environmental stressors ...
J. Martina, R. Puertollano
semanticscholar   +1 more source

Establishment of a PPP2CA homozygous knockout human embryonic stem cell line via CRISPR/Cas9 system

Stem Cell Research, 2023
Protein phosphatase 2A (PPP2CA) is one of the four main Ser/Thr phosphatase enzymes, which involved in the negative control of cell growth and division. PPP2CA is the main protein phosphatase in the heart, which regulates Ca (2+) through a series of ion ...
Tongbin Ding, Zhe Gao, Hang Liu, Yuan Li, Shichao Liu, Liguo Jian   +5 more
doaj   +1 more source

Transient PP2A inhibition alleviates normal tissue stem cell susceptibility to cell death during radiotherapy [PDF]

, 2018
Unintended outcomes of cancer therapy include ionizing radiation (IR)-induced stem cell depletion, diminished regenerative capacity, and accelerated aging.
Fabbrizi, Maria Rita, Hallahan, Dennis E., Meyer, Barbara, Misri, Sandeep, Raj, Suyash, Sharma, Girdhar G., Zobel, Cheri L.   +6 more
core   +3 more sources

Protein phosphatase 2A in Alzheimer's disease

Pathophysiology, 2009
Protein phosphatase 2A (PP2A) is the predominant serine/threonine phosphatase in eukaryotic cells. In Alzheimer's disease (AD), PP2A activity is decreased. Decreased PP2A activity is suggested to be involved in NFT formation and neurodegeneration. PP2A is also involved in APP secreting pathway, thus probably participating the Abeta production. Based on
Rong, Liu, Jian-Zhi, Wang
openaire   +2 more sources

Isolation and partial characterization of a protein with HMG-CoA reductase phosphatase activity associated with rat liver microsomal membranes.

Journal of Lipid Research, 1991
Several rat liver HMG-CoA-reductase (HMG-CoA-Rd) phosphatase activities have been shown to be associated with the endoplasmic reticulum. These activities were not due to glycogen contamination, as judged not only from different patterns of solubilization
G Asins, D Serra, FG Hegardt
doaj   +1 more source

Pharmacologic inhibition of protein phosphatase-2A achieves durable immune-mediated antitumor activity when combined with PD-1 blockade

Nature Communications, 2018
Mounting evidence suggests that inhibition of protein phosphatase-2A (PP2A), a serine/threonine phosphatase, could enhance anticancer immunity. However, drugs targeting PP2A are not currently available. Here, we report that a PP2A inhibitor, LB-100, when
W. Ho, Herui Wang, D. Maggio, J. Kovach, Qi Zhang, Qi Song, F. Marincola, John D Heiss, M. Gilbert, Rongze Lu, Z. Zhuang   +10 more
semanticscholar   +1 more source

Mechanisms of the scaffold subunit in facilitating protein phosphatase 2A methylation. [PDF]

PLoS ONE, 2014
The function of the biologically essential protein phosphatase 2A (PP2A) relies on formation of diverse heterotrimeric holoenzymes, which involves stable association between PP2A scaffold (A) and catalytic (C or PP2Ac) subunits and binding of variable ...
Vitali Stanevich, Aiping Zheng, Feng Guo, Li Jiang, Nathan Wlodarchak, Yongna Xing   +5 more
doaj   +1 more source