PECAM-1 engagement counteracts ICAM-1-induced signaling in brain vascular endothelial cells [PDF]
, 2007 Interactions between leukocytes and vascular endothelial cells are mediated by a complex set of membrane adhesion molecules which transduce bi-directional signals in both cell types.
Adamson +53 more
core +2 more sources
Marine Longilenes, Oxasqualenoids with Ser-Thr Protein Phosphatase 2A Inhibition Activity
Marine Drugs, 2018 The red seaweed Laurencia viridis is a rich source of oxygenated secondary metabolites that were derived from squalene. We report here the structures of three novel compounds, (+)-longilene peroxide (1), longilene (2), and (+)-prelongilene (3) that were ...
Francisco Cen-Pacheco +5 more
doaj +1 more source
FEBS Open Bio, 2018 Reversible methyl‐esterification (methylation) of Leu309 in the protein phosphatase 2A catalytic subunit (PP2Ac) is essential for proper biogenesis of the PP2A holoenzyme.
Ryotaro Yabe +6 more
doaj +1 more source
Tau hyperphosphorylation correlates with reduced methylation of protein phosphatase 2A
Neurobiology of Disease, 2008 The down-regulation of protein phosphatase 2A (PP2A) activity is thought to play an important role in the formation of tau hyperphosphorylation in the Alzheimer's disease (AD) brain. Methylation of the PP2A catalytic subunit at the L309 site can potently
Xin-Wen Zhou +6 more
doaj +1 more source
Protein interactome of the Cancerous Inhibitor of protein phosphatase 2A (CIP2A) in Th17 cells
Current Research in Immunology, 2020 Cancerous inhibitor of protein phosphatase 2A (CIP2A) is involved in immune response, cancer progression, and Alzheimer's disease. However, an understanding of the mechanistic basis of its function in this wide spectrum of physiological and pathological ...
Mohd Moin Khan +11 more
doaj +1 more source
Protein Phosphatase 2A in the Regulation of Wnt Signaling, Stem Cells, and Cancer
Genes, 2018 Protein phosphorylation is a ubiquitous cellular process that allows for the nuanced and reversible regulation of protein activity. Protein phosphatase 2A (PP2A) is a heterotrimeric serine-threonine phosphatase—composed of a structural, regulatory, and ...
Joshua J Thompson +1 more
semanticscholar +1 more source
The serine/threonine protein phosphatase 2A controls autoimmunity. [PDF]
Clinical Immunology, 2017 Protein phosphatase 2A (PP2A) is the first serine/threonine phosphatase recognized to contribute to human and murine lupus immunopathology. PP2A expression in SLE is controlled both epigenetically and genetically, and it is increased in patients with SLE, which contributes to decreased IL-2 production, decreased CD3ζ and increased FcRγ expression on ...
A. Sharabi, I. Kasper, G. Tsokos
semanticscholar +3 more sources
Free Fatty Acids Inhibit Protein Tyrosine Phosphatase 1B and Activate Akt
Cellular Physiology and Biochemistry, 2013 Background/Aims: Accumulating evidence has suggested that free fatty acids (FFAs) interact with protein kinases and protein phosphatases. The present study examined the effect of FFAs on protein phosphatases and Akt.
Eisuke Shibata +6 more
doaj +1 more source
Phosphoproteomics identifies a bimodal EPHA2 receptor switch that promotes embryonic stem cell differentiation [PDF]
, 2020 Embryonic Stem Cell (ESC) differentiation requires complex cell signalling network dynamics, although the key molecular events remain poorly understood.
Budzyk, Manon +10 more
core +2 more sources
Protein Phosphatase 2A Facilitates Axonogenesis by Dephosphorylating CRMP2 [PDF]
The Journal of Neuroscience, 2010 Protein phosphatase 2A (PP2A) is indispensable in development, and deficits of PP2A and deterioration of neuronal axons have been observed in several neurodegenerative disorders, but the direct link between PP2A and the neuronal axon development is still missing. Here, we show that PP2A is essential for axon development in transfected rat brain and the
Ling-Qiang, Zhu +6 more
openaire +2 more sources