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Precise Regulation of Membrane Proteins: From Physical Technology to Biomolecular Strategy
Advanced Science, EarlyView.This review summarizes the emerging strategies for the precise regulation of membrane proteins using physical stimuli and biomolecule‐based tools. These methods provide new insights into cell regulation and offer promising directions for future disease treatment.
Xiu Zhao +6 more
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Protein phosphatase 1 dephosphorylates Orc2
Biochemical and Biophysical Research Communications, 2014Phosphorylation of Thr(116) and Thr(226) on Orc2, one of the six subunits of the origin recognition complex (ORC), by cyclin A/CDK2 during S phase leads to the dissociation of Orc2, Orc3, Orc4, and Orc5 subunits (Orc2-5) from human chromatin and replication origins. The phosphorylated Orc2 becomes dephosphorylated in the late M phase of the cell cycle.
Kyung Yong, Lee +3 more
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Protein phosphatase-1 and insulin action
Molecular and Cellular Biochemistry, 1998Protein Phosphatase-1 (PP-1) appears to be the key component of the insulin signalling pathway which is responsible for bridging the initial insulin-simulated phosphorylation cascade with the ultimate dephosphorylation of insulin sensitive substrates.
L, Ragolia, N, Begum
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Tautomycin’s Interactions with Protein Phosphatase 1
Chemistry – An Asian Journal, 2010AbstractIt has been a long journey since tautomycin (TTM) was isolated in 1987 and the discovery that it inhibited protein phosphatase 1 (PP1) more strongly than PP2A until finally the cocrystal structure of TTM and PP1 was presented early in 2009. The fact that TTM shows preference to inhibit PP1 over PP2A makes this compound unique among the known ...
Magne O, Sydnes, Minoru, Isobe
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2003
Protein phosphatase 1 (PP1) is one of the first protein phosphatases whose activity was detected and whose catalytic subunit (PP1c) was purified and cloned. It is the representative of the most ancient protein phosphatase family that has a ubiquitous distribution in all eukaryotic organisms. The high level of conservation of the amino acid sequence and
Viktor Dombrádi +2 more
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Protein phosphatase 1 (PP1) is one of the first protein phosphatases whose activity was detected and whose catalytic subunit (PP1c) was purified and cloned. It is the representative of the most ancient protein phosphatase family that has a ubiquitous distribution in all eukaryotic organisms. The high level of conservation of the amino acid sequence and
Viktor Dombrádi +2 more
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Assay of Protein Phosphatase 1 Complexes
2003Publisher Summary This chapter provides an overview on assay of Protein phosphatase 1 (PP1) complexes. PP1 catalyzes the dephosphorylation of serine and threonine residues in proteins at neutral pH. The PP1 catalytic subunit is a member of the PPP family of protein phosphatases, and found in complex form, compared to a variety of different regulatory
Patricia T, Cohen +3 more
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Phosphoprotein Inhibitors of Protein Phosphatase-1
2003Publisher Summary The chapter discusses phosphoprotein inhibitors of protein phosphatase-1(PP1). Over 25 years ago, a search for proteins that could regulate phosphorylase phosphatase yielded heat-stable proteins that were called “inhibitor-1” (I-1) and “inhibitor-2” (I-2).
Masumi, Eto +3 more
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Combinatorial control of protein phosphatase-1
Trends in Biochemical Sciences, 2001The catalytic subunit of the type 1 Ser/Thr protein phosphatases (PP1) can interact with many different regulatory (R) subunits. These R subunits function as activity-modulators, targeting subunits and/or substrates. The specificity of the R subunits can be accounted for by their interaction with specific subsets of binding pockets on the catalytic ...
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Validation of Interactions with Protein Phosphatase-1
2003Publisher Summary This chapter presents an overview of the techniques that are available to study the interaction of protein phosphatase 1 (PP1) with other proteins. Most interactors of PP1 are inhibitors of the phosphorylase phosphatase activity of the catalytic subunit.
Aleyde, Van Eynde, Mathieu, Bollen
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