Results 41 to 50 of about 882,449 (295)

TCTEX1D4, a novel protein phosphatase 1 interactor: connecting the phosphatase to the microtubule network

Biology Open, 2013
Summary Reversible phosphorylation plays an important role as a mechanism of intracellular control in eukaryotes. PPP1, a major eukaryotic Ser/Thr-protein phosphatase, acquires its specificity by interacting with different protein regulators, also known ...
Luís Korrodi-Gregório, Sandra I. Vieira, Sara L. C. Esteves, Joana V. Silva, Maria João Freitas, Ann-Kristin Brauns, Georg Luers, Joana Abrantes, Pedro J. Esteves, Odete A. B. da Cruz e Silva, Margarida Fardilha, Edgar F. da Cruz e Silva   +11 more
doaj   +1 more source

PPM1D Knockdown Suppresses Cell Proliferation, Promotes Cell Apoptosis, and Activates p38 MAPK/p53 Signaling Pathway in Acute Myeloid Leukemia

Technology in Cancer Research & Treatment, 2020
Objectives: This study was to explore the effect of protein phosphatase, Mg 2+ /Mn 2+ dependent 1D knockdown on proliferation and apoptosis as well as p38 MAPK/p53 signaling pathway in acute myeloid leukemia.
Bin Li MD, Jie Hu MD, Di He BS, Qi Chen MD, Suna Liu BS, Xiaoling Zhu MD, Meijia Yu MD   +6 more
doaj   +1 more source

Hanks-Type Serine/Threonine Protein Kinases and Phosphatases in Bacteria: Roles in Signaling and Adaptation to Various Environments [PDF]

, 2018
Reversible phosphorylation is a key mechanism that regulates many cellular processes in prokaryotes and eukaryotes. In prokaryotes, signal transduction includes two-component signaling systems, which involve a membrane sensor histidine kinase and a ...
Janczarek, Monika, Karaś, Magdalena, Lipa, Paulina, Vinardell González, José María   +3 more
core   +1 more source

Liposomal C6 Ceramide Activates Protein Phosphatase 1 to Inhibit Melanoma Cells. [PDF]

PLoS ONE, 2016
Melanoma is one common skin cancer. In the present study, the potential anti-melanoma activity by a liposomal C6 ceramide was tested in vitro. We showed that the liposomal C6 (ceramide) was cytotoxic and anti-proliferative against a panel of human ...
Fangzhen Jiang, Kai Jin, Shenyu Huang, Qi Bao, Zheren Shao, Xueqing Hu, Juan Ye   +6 more
doaj   +1 more source

Structural basis of protein phosphatase 1 regulation [PDF]

Nature, 2004
The coordinated and reciprocal action of serine/threonine (Ser/Thr) protein kinases and phosphatases produces transient phosphorylation, a fundamental regulatory mechanism for many biological processes. The human genome encodes a far greater number of Ser/Thr protein kinases than of phosphatases.
Terrak, Mohammed, Kerff, Frédéric, Langsetmo, K., Tao, T., Dominguez, R.   +4 more
openaire   +3 more sources

Integration of a Phosphatase Cascade with the MAP Kinase Pathway provides for a Novel Signal Processing Function [PDF]

, 2009
We mathematically modeled the receptor-activated MAP kinase signaling by incorporating the regulation through cellular phosphatases. Activation induced the alignment of a phosphatase cascade in parallel with the MAP kinase pathway.
Alon, Altan-Bonnet, Bettini, Bhalla, Birtwistle, Blüthgen, Bollen, Brondello, Camps, Castelli, Chang, Cobb, Cyert, Das, Dickinson, Dickinson, Ebisuya, Echevarria, Eungdamrong, Ferrell, Friedman, Hatakeyama, Heinrich, Huang, Karlsson, Keyse, Kholodenko, Kolch, Kolch, Kumar, Kumar, Kurosaki, Kurosaki, Kurosaki, Kurosaki, Kurosaki, Levchenko, Locasale, Manders, Muda, Orton, Qiao, Raman, Reth, Rolli, Santos, Schmidt, Singh, Tan, Tian, Ueki, Widmann, Zandomeni, Zhao, Zi   +54 more
core   +3 more sources

Protein phosphatases 1, 2A, and 2C are protein histidine phosphatases.

Journal of Biological Chemistry, 1993
Eukaryotic cellular proteins contain phosphohistidine. To search for protein histidine phosphatases, protein histidine kinase from Saccharomyces cerevisiae was used to phosphorylate histone H4 on histidine at position 75 in the H4 amino acid sequence. Incubation of the phosphorylated histone H4 with either protein phosphatase 1, 2A, or 2C resulted in ...
Kim, Y., Huang, J., Cohen, P., Matthews, H. R.   +3 more
openaire   +2 more sources

Identification of a protein phosphatase-1/phospholamban complex that is regulated by cAMP-dependent phosphorylation.

PLoS ONE, 2013
In human and experimental heart failure, the activity of the type 1 phosphatase is significantly increased, associated with dephosphorylation of phospholamban, inhibition of the sarco(endo)plasmic reticulum Ca(2+) transport ATPase (SERCA2a) and depressed
Elizabeth Vafiadaki, Demetrios A Arvanitis, Despina Sanoudou, Evangelia G Kranias   +3 more
doaj   +1 more source

Microcystins: Potent xenobiotics [PDF]

Archive of Oncology, 2011
Having in mind that exposure to low levels of microcystin in drinking water represents the health risk for people, microcystins can be observed as potent xenobiotics.
Ilić Maja, Svirčev Zorica, Baltić Vladimir   +2 more
doaj   +1 more source

Inducible expression of catalytically active type 1 serine/threonine protein phosphatase in a human carcinoma cell line

Cancer Cell International, 2003
Background One of the major cellular serine/threonine protein phosphatases is protein phosphatase type 1 (PP1). Studies employing many eukaryotic systems all point to a crucial role for PP1 activity in controlling cell cycle progression.
Klover Peter, Messing Edward M, Sowden Mark P, Reeder Jay E, Villa-Moruzzi Emma, Ludlow John W   +5 more
doaj   +1 more source