Results 111 to 120 of about 4,194,516 (299)

PROTEIN PHOSPHATASE 2A (PP2A) AS A THERAPEUTIC TARGET IN ACUTE MYELOID LEUKEMIA

Frontiers in Oncology, 2016
Acute myeloid leukemia (AML) is a heterogeneous malignant disorder of hematopoietic progenitor cells in which several genetic and epigenetic aberrations have been described.
Elena eArriazu, Raffaella ePippa, Maria D Odero   +2 more
doaj   +1 more source

Threonine 348 regulates the subcellular localization of PTEN

FEBS Open Bio, EarlyView.
Thr348 in the C2 domain is a key contributor to PTEN subcellular localization. The PTEN350 fragment and PTENA4 accumulated in the nucleus, whereas PTENK13R,A4 predominantly localized to the plasma membrane. In contrast, substitution of Thr348 with Asp (T348D) disrupted these characteristic localization patterns, resulting in predominant cytoplasmic ...
Takashi Kato, Suzu Tanaka, Miyu Ohashi
wiley   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Anhydride modified cantharidin analogues. Is ring opening important in the inhibition of protein phosphatase 2A?

, 2000
A series of anhydride modified cantharidin analogues have been synthesised and screened for their ability to inhibit protein phosphatase 2A. Surprisingly only analogues capable of undergoing a facile ring opening of the anhydride moiety displayed any ...
Mirella A. Keane, McCluskey, A, Ronald J. Quinn, Quinn, RJ, Adam McCluskey, Jennette Sakoff, Alistair T.R. Sim, Mudgee, LM, Sakoff, J, Lisa-Maree Mudgee, Keane, MA, Sim, ATR   +11 more
core   +1 more source

Tools for probing 2A sequence space [PDF]

, 2009
Foot-and-mouth disease virus (FMDV) 2A is an oligopeptide composed of only 18 amino acids that can mediate a co-translational cleavage at its own C- terminus.
Escuin Ordinas, Helena
core   +2 more sources

Roles of Phosphotase 2A in Nociceptive Signal Processing

Molecular Pain, 2013
Multiple protein kinases affect the responses of dorsal horn neurons through phosphorylation of synaptic receptors and proteins involved in intracellular signal transduction pathways, and the consequences of this modulation may be spinal central ...
Yun Wang, Yongzhong Lei, Li Fang, Yonggao Mu, Jing Wu, Xuan Zhang   +5 more
doaj   +1 more source

Protein phosphatase 2A modulates podocyte maturation and glomerular functional integrity in mice

Cell Communication and Signaling, 2019
Background Protein phosphorylation & dephosphorylation are ubiquitous cellular processes that allow for the nuanced and reversible regulation of protein activity.
Xiujuan Zhu, Yuhong Ye, Chengxian Xu, Cunji Gao, Yingying Zhang, Jing Zhou, Weiqiang Lin, Jianhua Mao   +7 more
doaj   +1 more source

NEURONAL FUNCTIONS OF PROTEIN PHOSPHATASE 2A [PDF]

American Journal of Neuroscience, 2013
Reversible protein phosphorylation is a common and important form of protein posttranslational modification which determines the proteins’ activities, substrate specificity and inhibitions or degradations, depending on the specific amino acid residue, or combination of residues, being targeted.
openaire   +1 more source

Dactolisib outperforms Rapamycin in potentiating apoptosis induced by XPO1, Bcl‐2 and Mcl‐1 blockade in preclinical glioblastoma models

FEBS Open Bio, EarlyView.
The PAM pathway and its impact on cellular metabolism. Color‐coded key symbols represent Rapamycin (R, orange, targeting mTOR) and Dactolisib (D, green, targeting PI3K/mTOR), indicating their sites of action. Created with BioRenders.com. Glioblastoma resists therapy through interconnected survival programs.
Kai Zhao, Leonie Meyer, Madita Braun, Katharina Otte, Celine Bitter, Maite Pawlik, Hartmann Raifer, Frederik Helmprobst, Axel Pagenstecher, Hans Urban, Michael C. Burger, Michael W. Ronellenfitsch, Joachim P. Steinbach, Jarmila Jedelská, Shamim Bagheri, Behrooz H. Yousefi, Pietro Di Fazio, Markus Luster, Andreas H. Mahnken, Andreas Neubauer, Andreas Burchert, Christopher Nimsky, Jörg W. Bartsch, Tillmann Rusch   +23 more
wiley   +1 more source

Histone chaperone NAP1 mediates sister chromatid resolution by counteracting protein phosphatase 2A.

PLoS Genetics, 2013
Chromosome duplication and transmission into daughter cells requires the precisely orchestrated binding and release of cohesin. We found that the Drosophila histone chaperone NAP1 is required for cohesin release and sister chromatid resolution during ...
Yuri M Moshkin, Cecile M Doyen, Tsung-Wai Kan, Gillian E Chalkley, Karen Sap, Karel Bezstarosti, Jeroen A Demmers, Zeliha Ozgur, Wilfred F J van Ijcken, C Peter Verrijzer   +9 more
doaj   +1 more source