Results 11 to 20 of about 29,094 (272)
Neuroprotective Secreted Amyloid Precursor Protein Acts by Disrupting Amyloid Precursor Protein Dimers [PDF]
The amyloid precursor protein (APP) is implied both in cell growth and differentiation and in neurodegenerative processes in Alzheimer disease. Regulated proteolysis of APP generates biologically active fragments such as the neuroprotective secreted ectodomain sAPPalpha and the neurotoxic beta-amyloid peptide.
Gralle, M.+2 more
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The neuroendocrine polypeptide 7B2 is a precursor protein. [PDF]
The neuroendocrine protein 7B2 is highly conserved and widely present in neurons and endocrine cells. It is coexpressed with the prohormone proopiomelanocortin (POMC) in the intermediate lobe of the pituitary gland of Xenopus laevis. To study the biosynthesis of 7B2 in this amphibian, an anti-7B2 monoclonal antibody was used in immunoprecipitation ...
Ayoubi, T.A.+6 more
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We studied the effect of a recombinant murine TNF (rmTNF) and TNF-binding protein of Variola virus (VARV-CrmB) upon colony-forming ability of bone marrow cells (BMC) from Balb/c mice.
L. B. Toporkova+3 more
doaj +1 more source
Amyloid precursor protein and amyloid precursor-like protein 2 in cancer
Amyloid precursor protein (APP) and its family members amyloid precursor-like protein 1 (APLP1) and amyloid precursor-like protein 2 (APLP2) are type 1 transmembrane glycoproteins that are highly conserved across species. The transcriptional regulation of APP and APLP2 is similar but not identical, and the cleavage of both proteins is regulated by ...
Joyce C. Solheim+13 more
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ENTAIL: yEt aNoTher amyloid fIbrils cLassifier
Background This research aims to increase our knowledge of amyloidoses. These disorders cause incorrect protein folding, affecting protein functionality (on structure).
Alessia Auriemma Citarella+3 more
doaj +1 more source
Mitochondrial import receptors for precursor proteins [PDF]
The specific targeting of precursor proteins synthesized in the cytosol to various cell organelles is a central aspect of intracellular protein traffic. Several hundred different proteins are imported from the cytosol into the mitochondria. Recent studies have identified the mitochondrial outer membrane proteins MOM19, MOM72, MOM38 (approximately ISP42)
Pfanner, Nikolaus+2 more
openaire +5 more sources
Computer-aided characteristics of proteins as potential precursors of bioactive peptides
Proteins, apart from their basic functions, may play the role of precursors of the peptides that regulate the body functions and/or show antihypertensive, antithrombotic, antiamnestic, immunomodulating and other activities. Computer analysis of 109
Jerzy Dziuba
doaj +1 more source
AMYPdb: A database dedicated to amyloid precursor proteins [PDF]
Abstract Background Misfolding and aggregation of proteins into ordered fibrillar structures is associated with a number of severe pathologies, including Alzheimer's disease, prion diseases, and type II diabetes. The rapid accumulation of knowledge about the sequences and structures of these proteins allows using of ...
Le Béchec, Antony+2 more
openaire +9 more sources
Many of the small ribosomal subunit proteins are required for the stabilisation of late small ribosomal subunit (SSU) precursors and for final SSU rRNA processing in S. cerevisiae.
Jan Linnemann+6 more
doaj +1 more source
Structural transitions during large ribosomal subunit maturation analyzed by tethered nuclease structure probing in S. cerevisiae. [PDF]
Yeast large ribosomal subunit (LSU) precursors are subject to substantial changes in protein composition during their maturation due to coordinated transient interactions with a large number of ribosome biogenesis factors and due to the assembly of ...
Gisela Pöll+8 more
doaj +1 more source