Results 11 to 20 of about 29,094 (272)

Neuroprotective Secreted Amyloid Precursor Protein Acts by Disrupting Amyloid Precursor Protein Dimers [PDF]

Journal of Biological Chemistry, 2009
The amyloid precursor protein (APP) is implied both in cell growth and differentiation and in neurodegenerative processes in Alzheimer disease. Regulated proteolysis of APP generates biologically active fragments such as the neuroprotective secreted ectodomain sAPPalpha and the neurotoxic beta-amyloid peptide.
Gralle, M., Gralle Botelho, M., Wouters, F.   +2 more
openaire   +5 more sources

The neuroendocrine polypeptide 7B2 is a precursor protein. [PDF]

Journal of Biological Chemistry, 1990
The neuroendocrine protein 7B2 is highly conserved and widely present in neurons and endocrine cells. It is coexpressed with the prohormone proopiomelanocortin (POMC) in the intermediate lobe of the pituitary gland of Xenopus laevis. To study the biosynthesis of 7B2 in this amphibian, an anti-7B2 monoclonal antibody was used in immunoprecipitation ...
Ayoubi, T.A., van Duijnhoven, H.L., van de Ven, W.J., Jenks, B.G., Jenks, B.G., Roubos, E.W., Martens, G.J.M.   +6 more
openaire   +3 more sources

RECOMBINANT PROTEIN OF VARIOLA VIRUS ABOLISHES THE EFFECTS OF TUMOR NECROSIS FACTOR UPON MARROW HEMATOPOIESIS IN BALB/С MICE

Медицинская иммунология, 2014
We studied the effect of a recombinant murine TNF (rmTNF) and TNF-binding protein of Variola virus (VARV-CrmB) upon colony-forming ability of bone marrow cells (BMC) from Balb/c mice.
L. B. Toporkova, A. A. Petuhova, I. P. Gileva, I. A. Orlovskaya   +3 more
doaj   +1 more source

Amyloid precursor protein and amyloid precursor-like protein 2 in cancer

Oncotarget, 2016
Amyloid precursor protein (APP) and its family members amyloid precursor-like protein 1 (APLP1) and amyloid precursor-like protein 2 (APLP2) are type 1 transmembrane glycoproteins that are highly conserved across species. The transcriptional regulation of APP and APLP2 is similar but not identical, and the cleavage of both proteins is regulated by ...
Joyce C. Solheim, Jixin Dong, Don W. Coulter, Jonathan Herskovitz, Abhilasha Purohit, Bailee H. Sliker, Rakesh K. Singh, Haley L. Peters, Haley L. Peters, Surinder K. Batra, Amit Tuli, Amit Tuli, Kaitlin Smits, Poomy Pandey   +13 more
openaire   +3 more sources

ENTAIL: yEt aNoTher amyloid fIbrils cLassifier

BMC Bioinformatics, 2022
Background This research aims to increase our knowledge of amyloidoses. These disorders cause incorrect protein folding, affecting protein functionality (on structure).
Alessia Auriemma Citarella, Luigi Di Biasi, Fabiola De Marco, Genoveffa Tortora   +3 more
doaj   +1 more source

Mitochondrial import receptors for precursor proteins [PDF]

Trends in Biochemical Sciences, 1991
The specific targeting of precursor proteins synthesized in the cytosol to various cell organelles is a central aspect of intracellular protein traffic. Several hundred different proteins are imported from the cytosol into the mitochondria. Recent studies have identified the mitochondrial outer membrane proteins MOM19, MOM72, MOM38 (approximately ISP42)
Pfanner, Nikolaus, Söllner, Thomas, Neupert, Walter   +2 more
openaire   +5 more sources

Computer-aided characteristics of proteins as potential precursors of bioactive peptides

Polimery, 2003
Proteins, apart from their basic functions, may play the role of precursors of the peptides that regulate the body functions and/or show anti­hypertensive, antithrombotic, antiamnestic, immunomodulating and other activities. Computer analysis of 109
Jerzy Dziuba
doaj   +1 more source

AMYPdb: A database dedicated to amyloid precursor proteins [PDF]

BMC Bioinformatics, 2008
Abstract Background Misfolding and aggregation of proteins into ordered fibrillar structures is associated with a number of severe pathologies, including Alzheimer's disease, prion diseases, and type II diabetes. The rapid accumulation of knowledge about the sequences and structures of these proteins allows using of ...
Le Béchec, Antony, Pawlicki, Sandrine, Delamarche, Christian   +2 more
openaire   +9 more sources

Impact of two neighbouring ribosomal protein clusters on biogenesis factor binding and assembly of yeast late small ribosomal subunit precursors.

PLoS ONE, 2019
Many of the small ribosomal subunit proteins are required for the stabilisation of late small ribosomal subunit (SSU) precursors and for final SSU rRNA processing in S. cerevisiae.
Jan Linnemann, Gisela Pöll, Steffen Jakob, Sébastien Ferreira-Cerca, Joachim Griesenbeck, Herbert Tschochner, Philipp Milkereit   +6 more
doaj   +1 more source

Structural transitions during large ribosomal subunit maturation analyzed by tethered nuclease structure probing in S. cerevisiae. [PDF]

PLoS ONE, 2017
Yeast large ribosomal subunit (LSU) precursors are subject to substantial changes in protein composition during their maturation due to coordinated transient interactions with a large number of ribosome biogenesis factors and due to the assembly of ...
Gisela Pöll, Christian Müller, Malena Bodden, Fabian Teubl, Norbert Eichner, Gerhard Lehmann, Joachim Griesenbeck, Herbert Tschochner, Philipp Milkereit   +8 more
doaj   +1 more source