Results 11 to 20 of about 562,686 (340)

Mitochondrial import receptors for precursor proteins [PDF]

Trends in Biochemical Sciences, 1991
The specific targeting of precursor proteins synthesized in the cytosol to various cell organelles is a central aspect of intracellular protein traffic. Several hundred different proteins are imported from the cytosol into the mitochondria.
Attardi, Baker, Deshaies, Gillespie, Hartl, Hines, Horwich, Hwang, Kang, Kiebler, Klingenberg, Meyer, Murakami, Murakami, Murakami, Ono, Pain, Pfaller, Pfaller, Pfanner, Pfanner, Pfanner, Pfanner, Pfanner, Pfanner, Riezman, Roise, Rosenberg, Schnell, Sheffield, So¨llner, So¨llner, Steger, Vestweber, Wickner   +34 more
core   +7 more sources

Precursor Protein for Newcastle Disease Virus [PDF]

Journal of Virology, 1973
The course of viral protein synthesis during infection of chicken embryo fibroblasts with Newcastle disease virus (NDV) L. Kansas has been followed by using sodium dodecyl sulfate polyacrylamide gel electrophoresis. Of the three major virion polypeptide molecular weight classes, I (78,400 daltons), II (53,500 daltons), and III (37,600 daltons), only II,
A. C. R. Samson, Colin Fox
openalex   +5 more sources

Chloroplast precursor protein translocon [PDF]

FEBS Letters, 1999
Chloroplasts are believed to have originated from a photosynthetic, prokaryotic ancestor. As the result of endosymbiotic evolution, most of the genes of the endocytobiont were displaced to the host nucleus. Today's chloroplasts must import most of their proteins from the cytosol as precursors.
Jürgen Soll, Timo May
openaire   +3 more sources

Nucleation precursors in protein crystallization [PDF]

Acta Crystallographica Section F Structural Biology Communications, 2014
Protein crystal nucleation is a central problem in biological crystallography and other areas of science, technology and medicine. Recent studies have demonstrated that protein crystal nuclei form within crucial precursors. Here, methods of detection and characterization of the precursors are reviewed: dynamic light scattering, atomic force microscopy ...
Peter G. Vekilov, Maria A. Vorontsova
openaire   +3 more sources

In Silico Evidence That Protein Unfolding is a Precursor of Protein Aggregation [PDF]

ChemPhysChem, 2020
AbstractWe present a computational study on the folding and aggregation of proteins in an aqueous environment, as a function of its concentration. We show how the increase of the concentration of individual protein species can induce a partial unfolding of the native conformation without the occurrence of aggregates.
Valentino Bianco, Giancarlo Franzese, Ivan Coluzza   +2 more
openaire   +7 more sources

Biology and pathophysiology of the amyloid precursor protein [PDF]

Molecular Neurodegeneration, 2011
The amyloid precursor protein (APP) plays a central role in the pathophysiology of Alzheimer's disease in large part due to the sequential proteolytic cleavages that result in the generation of β-amyloid peptides (Aβ). Not surprisingly, the biological properties of APP have also been the subject of great interest and intense investigations.
Zheng, Hui, Koo, Edward H
openaire   +6 more sources

Neuroprotective Secreted Amyloid Precursor Protein Acts by Disrupting Amyloid Precursor Protein Dimers [PDF]

Journal of Biological Chemistry, 2009
The amyloid precursor protein (APP) is implied both in cell growth and differentiation and in neurodegenerative processes in Alzheimer disease. Regulated proteolysis of APP generates biologically active fragments such as the neuroprotective secreted ectodomain sAPPalpha and the neurotoxic beta-amyloid peptide.
Gralle, M., Gralle Botelho, M., Wouters, F.   +2 more
openaire   +5 more sources

The neuroendocrine polypeptide 7B2 is a precursor protein. [PDF]

Journal of Biological Chemistry, 1990
The neuroendocrine protein 7B2 is highly conserved and widely present in neurons and endocrine cells. It is coexpressed with the prohormone proopiomelanocortin (POMC) in the intermediate lobe of the pituitary gland of Xenopus laevis. To study the biosynthesis of 7B2 in this amphibian, an anti-7B2 monoclonal antibody was used in immunoprecipitation ...
Ayoubi, T.A., van Duijnhoven, H.L., van de Ven, W.J., Jenks, B.G., Jenks, B.G., Roubos, E.W., Martens, G.J.M.   +6 more
openaire   +3 more sources

Protein folding causes an arrest of preprotein translocation into mitochondria in vivo [PDF]

, 1991
With vital yeast cells, a hybrid protein consisting of the amino- terminal third of the precursor to cytochrome b2 and of the entire dihydrofolate reductase was arrested on the import pathway into mitochondria.
Becker, Karin, Guiard, Bernard, Horwich, Arthur, Neupert, Walter, Pfanner, Nikolaus, Schleyer, Manfred, Tropschug, Maximilian, Wienhues, Ulla   +7 more
core   +3 more sources

Amyloid precursor protein and amyloid precursor-like protein 2 in cancer

Oncotarget, 2016
Amyloid precursor protein (APP) and its family members amyloid precursor-like protein 1 (APLP1) and amyloid precursor-like protein 2 (APLP2) are type 1 transmembrane glycoproteins that are highly conserved across species. The transcriptional regulation of APP and APLP2 is similar but not identical, and the cleavage of both proteins is regulated by ...
Joyce C. Solheim, Jixin Dong, Don W. Coulter, Jonathan Herskovitz, Abhilasha Purohit, Bailee H. Sliker, Rakesh K. Singh, Haley L. Peters, Haley L. Peters, Surinder K. Batra, Amit Tuli, Amit Tuli, Kaitlin Smits, Poomy Pandey   +13 more
openaire   +3 more sources