Results 11 to 20 of about 6,324,685 (356)
Cytosolic Quality Control of Mitochondrial Protein Precursors-The Early Stages of the Organelle Biogenesis. [PDF]
Int J Mol Sci, 2021 With few exceptions, proteins that constitute the proteome of mitochondria originate outside of this organelle in precursor forms. Such protein precursors follow dedicated transportation paths to reach specific parts of mitochondria, where they complete ...
Lenkiewicz AM +2 more
europepmc +2 more sources
SGTA associates with nascent membrane protein precursors. [PDF]
EMBO Rep, 2020 The endoplasmic reticulum (ER) is a major site for membrane protein synthesis in eukaryotes. The majority of integral membrane proteins are delivered to the ER membrane via the co‐translational, signal recognition particle (SRP)‐dependent route. However,
Leznicki P, High S.
europepmc +2 more sources
Delayed by Design: Role of Suboptimal Signal Peptidase Processing of Viral Structural Protein Precursors in Flaviviridae Virus Assembly. [PDF]
Viruses, 2020 The Flaviviridae virus family is classified into four different genera, including flavivirus, hepacivirus, pegivirus, and pestivirus, which cause significant morbidity and mortality in humans and other mammals, including ruminants and pigs.
Alzahrani N, Wu MJ, Shanmugam S, Yi M.
europepmc +2 more sources
In silico evidence that protein unfolding is as a precursor of the protein aggregation [PDF]
ChemPhysChem 2020, 21, 377, 2019 We present a computational study on the folding and aggregation of proteins in aqueous environment, as function of its concentration. We show how the increase of the concentration of individual protein species can induce a partial unfolding of the native conformation without the occurrence of aggregates. A further increment of the protein concentration
Valentino Bianco +2 more
arxiv +9 more sources
Expanding the repertoire of amyloid polymorphs by co-polymerization of related protein precursors. [PDF]
J Biol Chem, 2013 Background: Amyloid fibrils in vivo are rarely composed of a single protein, yet the consequences of co-polymerization of different proteins are relatively poorly understood.
Sarell CJ +7 more
europepmc +2 more sources
Incorporation of Labeled Nucleic Acid and Protein Precursors by Diapausing and Nondiapausing Blastocysts1, 2 [PDF]
Biology of Reproduction, 1969 precursors RNA proteins delayed implantation. These exceriments reveal the absence of labeled thymine incorpo- ration by diapausing blastocysts from mink, fur seal, and lactating rat, although thymine is incorporated by ...
Bela J. Gulyas, Joseph C. Daniel
openalex +2 more sources
Nucleation precursors in protein crystallization. [PDF]
Acta Crystallographica Section F Structural Biology Communications, 2014 Protein crystal nucleation is a central problem in biological crystallography and other areas of science, technology and medicine. Recent studies have demonstrated that protein crystal nuclei form within crucial precursors. Here, methods of detection and
P. Vekilov, M. Vorontsova
semanticscholar +4 more sources
Precursor Protein for Newcastle Disease Virus [PDF]
Journal of Virology, 1973 The course of viral protein synthesis during infection of chicken embryo fibroblasts with Newcastle disease virus (NDV) L. Kansas has been followed by using sodium dodecyl sulfate polyacrylamide gel electrophoresis. Of the three major virion polypeptide molecular weight classes, I (78,400 daltons), II (53,500 daltons), and III (37,600 daltons), only II,
A. C. R. Samson, Colin Fox
openalex +5 more sources
DIA-BERT: pre-trained end-to-end transformer models for enhanced DIA proteomics data analysis [PDF]
Nature CommunicationsData-independent acquisition mass spectrometry (DIA-MS) has become increasingly pivotal in quantitative proteomics. In this study, we present DIA-BERT, a software tool that harnesses a transformer-based pre-trained artificial intelligence (AI) model for ...
Zhiwei Liu +7 more
doaj +2 more sources
Biology, 2023 Research suggests that androgens increase skeletal muscle growth by modulating polyamine biosynthesis. As such, the objective of this study was to investigate effects of anabolic hormones, polyamine precursors, and polyamines relative to proliferation ...
Laura A. Motsinger +8 more
doaj +1 more source