Expression of prion protein in mouse erythroid progenitors and differentiating murine erythroleukemia cells. [PDF]
PLoS ONE, 2011 Prion diseases have been observed to deregulate the transcription of erythroid genes, and prion protein knockout mice have demonstrated a diminished response to experimental anemia.
Martin Panigaj +3 more
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Heteromers of amyloid precursor protein in cerebrospinal fluid [PDF]
Molecular Neurodegeneration, 2015 Soluble fragments of the amyloid precursor protein (APP) generated by α- and β-secretases, sAPPα and sAPPβ, have been postulated as promising new cerebrospinal fluid (CSF) biomarkers for the clinical diagnosis of Alzheimer's disease (AD). However, the capacity of these soluble proteins to assemble has not been explored and could be relevant. Our aim is
Cuchillo-Ibáñez, Inmaculada +6 more
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Journal of Genetic Engineering and Biotechnology, 2023 Background Finding natural products with anticancer activity is an effective strategy to fight this disease. In this respect, Lepidium sativum or garden cress (family Brassicaceae) has been widely used worldwide for its wide therapeutic application ...
Mona M. Ibrahim +2 more
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Binding of F-spondin to amyloid-β precursor protein: A candidate amyloid-β precursor protein ligand that modulates amyloid-β precursor protein cleavage [PDF]
Proceedings of the National Academy of Sciences, 2004 Amyloid-β precursor protein (APP), a type I membrane protein, is physiologically processed by α- or β-secretases that cleave APP N-terminal to the transmembrane region. Extracellular α-/β-cleavage of APP generates a large secreted N-terminal fragment, and a smaller cellular C-terminal fragment.
Thomas C. Südhof, Angela Ho
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Coupling enhanced sampling of the apo-receptor with template-based ligand conformers selection: Performance in pose prediction in the D3R-GC4 [PDF]
Journal of Computer-Aided Molecular Design 34, 149-162 (2020), 2020 We report the performance of our newly introduced Ensemble Docking with Enhanced sampling of pocket Shape (EDES) protocol coupled to a template-based algorithm to generate near-native ligand conformations in the 2019 iteration of the Grand Challenge organized by the D3R consortium.
arxiv +1 more source
The significant influence of residual feed intake on flavor precursors and biomolecules in slow-growing Korat chicken meat [PDF]
Animal Bioscience, 2021 Objective This study investigated the association between feed efficiency, physicochemical properties, flavor precursors and biomolecules in the thigh meat of Korat (KR) chickens.
Chotima Poompramun +3 more
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Congenital Dyserythropoietic Anemia Type II: molecular analysis and expression of the
Orphanet Journal of Rare Diseases, 2011 Background Congenital dyserythropoietic anemia type II (CDAII), the most common form of CDA, is an autosomal recessive condition. CDAII diagnosis is based on invasive, expensive, and time consuming tests that are available only in specialized ...
Punzo Francesca +9 more
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Intraneuronal compartments of the amyloid precursor protein [PDF]
The Journal of Neuroscience, 1993 The amyloid precursor protein (APP) is the parent molecule from which beta-amyloid protein is cleaved and deposits as amyloid fibrils in the senile plaques of Alzheimer's disease. Its primary structure resembles a receptor; however, no ligand has been identified. In growing hippocampal neurons APP is localized to growth cones.
Adriana Ferreira +2 more
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Out-of-equilibrium versus dynamical and thermodynamical transitions for a model protein [PDF]
Progress of Theoretical Physics Supplement No. 184 (2010) pp.
339-350, 2009 Equilibrium and out-of-equilibrium transitions of an off-lattice protein model have been identified and studied. In particular, the out-of-equilibrium dynamics of the protein undergoing mechanical unfolding is investigated, and by using a work fluctuation relation, the system free energy landscape is evaluated.
arxiv +1 more source
The role of Dicer protein partners in the processing of microRNA precursors. [PDF]
PLoS ONE, 2011 One of the cellular functions of the ribonuclease Dicer is to process microRNA precursors (pre-miRNAs) into mature microRNAs (miRNAs). Human Dicer performs this function in cooperation with its protein partners, AGO2, PACT and TRBP.
Edyta Koscianska +2 more
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