Results 21 to 30 of about 29,094 (272)

Expression of prion protein in mouse erythroid progenitors and differentiating murine erythroleukemia cells. [PDF]

open access: yesPLoS ONE, 2011
Prion diseases have been observed to deregulate the transcription of erythroid genes, and prion protein knockout mice have demonstrated a diminished response to experimental anemia.
Martin Panigaj   +3 more
doaj   +1 more source

Heteromers of amyloid precursor protein in cerebrospinal fluid [PDF]

open access: yesMolecular Neurodegeneration, 2015
Soluble fragments of the amyloid precursor protein (APP) generated by α- and β-secretases, sAPPα and sAPPβ, have been postulated as promising new cerebrospinal fluid (CSF) biomarkers for the clinical diagnosis of Alzheimer's disease (AD). However, the capacity of these soluble proteins to assemble has not been explored and could be relevant. Our aim is
Cuchillo-Ibáñez, Inmaculada   +6 more
openaire   +7 more sources

Targeting apoptotic anticancer response with natural glucosinolates from cell suspension culture of Lepidium sativum

open access: yesJournal of Genetic Engineering and Biotechnology, 2023
Background Finding natural products with anticancer activity is an effective strategy to fight this disease. In this respect, Lepidium sativum or garden cress (family Brassicaceae) has been widely used worldwide for its wide therapeutic application ...
Mona M. Ibrahim   +2 more
doaj   +1 more source

Binding of F-spondin to amyloid-β precursor protein: A candidate amyloid-β precursor protein ligand that modulates amyloid-β precursor protein cleavage [PDF]

open access: yesProceedings of the National Academy of Sciences, 2004
Amyloid-β precursor protein (APP), a type I membrane protein, is physiologically processed by α- or β-secretases that cleave APP N-terminal to the transmembrane region. Extracellular α-/β-cleavage of APP generates a large secreted N-terminal fragment, and a smaller cellular C-terminal fragment.
Thomas C. Südhof, Angela Ho
openaire   +3 more sources

Coupling enhanced sampling of the apo-receptor with template-based ligand conformers selection: Performance in pose prediction in the D3R-GC4 [PDF]

open access: yesJournal of Computer-Aided Molecular Design 34, 149-162 (2020), 2020
We report the performance of our newly introduced Ensemble Docking with Enhanced sampling of pocket Shape (EDES) protocol coupled to a template-based algorithm to generate near-native ligand conformations in the 2019 iteration of the Grand Challenge organized by the D3R consortium.
arxiv   +1 more source

The significant influence of residual feed intake on flavor precursors and biomolecules in slow-growing Korat chicken meat [PDF]

open access: yesAnimal Bioscience, 2021
Objective This study investigated the association between feed efficiency, physicochemical properties, flavor precursors and biomolecules in the thigh meat of Korat (KR) chickens.
Chotima Poompramun   +3 more
doaj   +1 more source

Congenital Dyserythropoietic Anemia Type II: molecular analysis and expression of the SEC23B Gene

open access: yesOrphanet Journal of Rare Diseases, 2011
Background Congenital dyserythropoietic anemia type II (CDAII), the most common form of CDA, is an autosomal recessive condition. CDAII diagnosis is based on invasive, expensive, and time consuming tests that are available only in specialized ...
Punzo Francesca   +9 more
doaj   +1 more source

Intraneuronal compartments of the amyloid precursor protein [PDF]

open access: yesThe Journal of Neuroscience, 1993
The amyloid precursor protein (APP) is the parent molecule from which beta-amyloid protein is cleaved and deposits as amyloid fibrils in the senile plaques of Alzheimer's disease. Its primary structure resembles a receptor; however, no ligand has been identified. In growing hippocampal neurons APP is localized to growth cones.
Adriana Ferreira   +2 more
openaire   +3 more sources

Out-of-equilibrium versus dynamical and thermodynamical transitions for a model protein [PDF]

open access: yesProgress of Theoretical Physics Supplement No. 184 (2010) pp. 339-350, 2009
Equilibrium and out-of-equilibrium transitions of an off-lattice protein model have been identified and studied. In particular, the out-of-equilibrium dynamics of the protein undergoing mechanical unfolding is investigated, and by using a work fluctuation relation, the system free energy landscape is evaluated.
arxiv   +1 more source

The role of Dicer protein partners in the processing of microRNA precursors. [PDF]

open access: yesPLoS ONE, 2011
One of the cellular functions of the ribonuclease Dicer is to process microRNA precursors (pre-miRNAs) into mature microRNAs (miRNAs). Human Dicer performs this function in cooperation with its protein partners, AGO2, PACT and TRBP.
Edyta Koscianska   +2 more
doaj   +1 more source

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