Results 31 to 40 of about 29,094 (272)

The Precursor of the α-Fibrous Protein of Epidermis

open access: yesJournal of Investigative Dermatology, 1971
Extraction of cow snout epidermis with citrate buffer pH 2.65 yields an α-fibrous protein (prekeratin) which can be purified by precipitation at pH 7.0, pH 6.0, pH 5.0 and pH 4.5. A precursor pool of α-fibrous protein has been identified in the microsomal fraction of homogenized tissue and this protein is also soluble in acid buffers at pH 2.65 and ...
Ann M. Gifford   +2 more
openaire   +3 more sources

Amyloid precursor protein processing and bioenergetics [PDF]

open access: yesBrain Research Bulletin, 2017
The processing of amyloid precursor protein (APP) to amyloid beta (Aβ) is of great interest to the Alzheimer's disease (AD) field. Decades of research define how APP is altered to form Aβ, and how Aβ generates oligomers, protofibrils, and fibrils. Numerous signaling pathways and changes in cell physiology are known to influence APP processing. Existing
Heather M. Wilkins, Russell H. Swerdlow
openaire   +3 more sources

Amyloid Precursor Protein and Alzheimer’s Disease

open access: yesInternational Journal of Molecular Sciences, 2023
Alzheimer’s disease (AD) is one of the most common neurodegenerative disorders associated with age or inherited mutations. It is characterized by severe dementia in the late stages that affect memory, cognitive functions, and daily life overall. AD progression is linked to the accumulation of cytotoxic amyloid beta (Aβ) and hyperphosphorylated tau ...
Kseniia S. Orobets, Andrey L. Karamyshev
openaire   +2 more sources

Effects of Chickpea Protein on Carbohydrate Reactivity in Acrylamide Formation in Low Humidity Model Systems

open access: yesFoods, 2020
Asparagine and reducing sugars are the principal precursors of acrylamide in foods. Their main sources in pastries are flour and hen egg yolks. One method of reducing acrylamide content in food may be to add a chickpea protein preparation. The aim of the
Karolina Miśkiewicz   +2 more
doaj   +1 more source

The amyloid precursor protein: beyond amyloid.

open access: yesMolecular neurodegeneration, 2006
The amyloid precursor protein (APP) takes a central position in Alzheimer's disease (AD) pathogenesis: APP processing generates the beta-amyloid (Abeta) peptides, which are deposited as the amyloid plaques in brains of AD individuals; Point mutations and duplications of APP are causal for a subset of early onset of familial Alzheimer's disease (FAD ...
Hui Zheng   +3 more
openaire   +4 more sources

Fast Proteome Identification and Quantification from Data-Dependent Acquisition - Tandem Mass Spectrometry using Free Software Tools [PDF]

open access: yesMethods and Protocols 2019, 2018
Identification of nearly all proteins in a system using data-dependent acquisition (DDA) mass spectrometry has become routine for simple organisms, such as bacteria and yeast. Still, quantification of the identified proteins may be a complex process and require multiple different software packages.
arxiv   +1 more source

Citrus psorosis virus 24K protein inhibits the processing of miRNA precursors by interacting with components of the biogenesis machinery

open access: yesMicrobiology Spectrum
Sweet orange (Citrus sinensis) is one of the most important fruit crops worldwide. Virus infections in this crop can interfere with cellular processes, causing dramatic economic losses. By performing RT-qPCR analyses, we demonstrated that citrus psorosis
Facundo E. Marmisolle   +7 more
doaj   +1 more source

Proteasomal degradation competes with Mia40-mediated import into mitochondria

open access: yesBMC Biology, 2018
Tandem fluorescent protein timers are elegant tools to determine proteolytic stabilities of cytosolic proteins with high spatial and temporal resolution. In a new study published in BMC Biology, Kowalski et al.
Eva Zöller   +2 more
doaj   +1 more source

Smooth muscle protein 22α-Cre recombination in resting cardiac fibroblasts and hematopoietic precursors

open access: yesScientific Reports, 2022
The Cre-loxP system has been widely used for cell- or organ-specific gene manipulation, but it is important to precisely understand what kind of cells the recombination takes place in.
Shinya Ikeda   +3 more
doaj   +1 more source

Motor recruitment to the TIM23 channel’s lateral gate restricts polypeptide release into the inner membrane

open access: yesNature Communications, 2018
The mitochondrial TIM23-complex facilitates anterograde precursor transport across the inner membrane into the matrix and lateral release of precursors into the membrane.
Alexander Benjamin Schendzielorz   +7 more
doaj   +1 more source

Home - About - Disclaimer - Privacy