Results 31 to 40 of about 6,324,685 (356)

Amyloid precursor protein and amyloid precursor-like protein 2 in cancer

open access: yesOncotarget, 2016
Amyloid precursor protein (APP) and its family members amyloid precursor-like protein 1 (APLP1) and amyloid precursor-like protein 2 (APLP2) are type 1 transmembrane glycoproteins that are highly conserved across species. The transcriptional regulation of APP and APLP2 is similar but not identical, and the cleavage of both proteins is regulated by ...
Joyce C. Solheim   +13 more
openaire   +3 more sources

Mitochondrial import receptors for precursor proteins [PDF]

open access: yesTrends in Biochemical Sciences, 1991
The specific targeting of precursor proteins synthesized in the cytosol to various cell organelles is a central aspect of intracellular protein traffic. Several hundred different proteins are imported from the cytosol into the mitochondria. Recent studies have identified the mitochondrial outer membrane proteins MOM19, MOM72, MOM38 (approximately ISP42)
Pfanner, Nikolaus   +2 more
openaire   +5 more sources

Computer-aided characteristics of proteins as potential precursors of bioactive peptides

open access: yesPolimery, 2003
Proteins, apart from their basic functions, may play the role of precursors of the peptides that regulate the body functions and/or show anti­hypertensive, antithrombotic, antiamnestic, immunomodulating and other activities. Computer analysis of 109
Jerzy Dziuba
doaj   +1 more source

ENTAIL: yEt aNoTher amyloid fIbrils cLassifier

open access: yesBMC Bioinformatics, 2022
Background This research aims to increase our knowledge of amyloidoses. These disorders cause incorrect protein folding, affecting protein functionality (on structure).
Alessia Auriemma Citarella   +3 more
doaj   +1 more source

AMYPdb: A database dedicated to amyloid precursor proteins [PDF]

open access: yesBMC Bioinformatics, 2008
Abstract Background Misfolding and aggregation of proteins into ordered fibrillar structures is associated with a number of severe pathologies, including Alzheimer's disease, prion diseases, and type II diabetes. The rapid accumulation of knowledge about the sequences and structures of these proteins allows using of ...
Le Béchec, Antony   +2 more
openaire   +9 more sources

Impact of two neighbouring ribosomal protein clusters on biogenesis factor binding and assembly of yeast late small ribosomal subunit precursors.

open access: yesPLoS ONE, 2019
Many of the small ribosomal subunit proteins are required for the stabilisation of late small ribosomal subunit (SSU) precursors and for final SSU rRNA processing in S. cerevisiae.
Jan Linnemann   +6 more
doaj   +1 more source

Expression of prion protein in mouse erythroid progenitors and differentiating murine erythroleukemia cells. [PDF]

open access: yesPLoS ONE, 2011
Prion diseases have been observed to deregulate the transcription of erythroid genes, and prion protein knockout mice have demonstrated a diminished response to experimental anemia.
Martin Panigaj   +3 more
doaj   +1 more source

Binding of F-spondin to amyloid-β precursor protein: A candidate amyloid-β precursor protein ligand that modulates amyloid-β precursor protein cleavage [PDF]

open access: yesProceedings of the National Academy of Sciences, 2004
Amyloid-β precursor protein (APP), a type I membrane protein, is physiologically processed by α- or β-secretases that cleave APP N-terminal to the transmembrane region. Extracellular α-/β-cleavage of APP generates a large secreted N-terminal fragment, and a smaller cellular C-terminal fragment.
Thomas C. Südhof, Angela Ho
openaire   +3 more sources

Structural transitions during large ribosomal subunit maturation analyzed by tethered nuclease structure probing in S. cerevisiae. [PDF]

open access: yesPLoS ONE, 2017
Yeast large ribosomal subunit (LSU) precursors are subject to substantial changes in protein composition during their maturation due to coordinated transient interactions with a large number of ribosome biogenesis factors and due to the assembly of ...
Gisela Pöll   +8 more
doaj   +1 more source

The Protein Precursors of Peptides That Affect the Mechanics of Connective Tissue and/or Muscle in the Echinoderm Apostichopus japonicus

open access: yesPLoS ONE, 2012
Peptides that cause muscle relaxation or contraction or that modulate electrically-induced muscle contraction have been discovered in the sea cucumber Apostichopus japonicus (Phylum Echinodermata; Class Holothuroidea). By analysing transcriptome sequence
M. Elphick
semanticscholar   +1 more source

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