Results 31 to 40 of about 29,094 (272)
The Precursor of the α-Fibrous Protein of Epidermis
Journal of Investigative Dermatology, 1971 Extraction of cow snout epidermis with citrate buffer pH 2.65 yields an α-fibrous protein (prekeratin) which can be purified by precipitation at pH 7.0, pH 6.0, pH 5.0 and pH 4.5. A precursor pool of α-fibrous protein has been identified in the microsomal fraction of homogenized tissue and this protein is also soluble in acid buffers at pH 2.65 and ...
Ann M. Gifford +2 more
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Amyloid precursor protein processing and bioenergetics [PDF]
Brain Research Bulletin, 2017 The processing of amyloid precursor protein (APP) to amyloid beta (Aβ) is of great interest to the Alzheimer's disease (AD) field. Decades of research define how APP is altered to form Aβ, and how Aβ generates oligomers, protofibrils, and fibrils. Numerous signaling pathways and changes in cell physiology are known to influence APP processing. Existing
Heather M. Wilkins, Russell H. Swerdlow
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Amyloid Precursor Protein and Alzheimer’s Disease
International Journal of Molecular Sciences, 2023 Alzheimer’s disease (AD) is one of the most common neurodegenerative disorders associated with age or inherited mutations. It is characterized by severe dementia in the late stages that affect memory, cognitive functions, and daily life overall. AD progression is linked to the accumulation of cytotoxic amyloid beta (Aβ) and hyperphosphorylated tau ...
Kseniia S. Orobets, Andrey L. Karamyshev
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Foods, 2020 Asparagine and reducing sugars are the principal precursors of acrylamide in foods. Their main sources in pastries are flour and hen egg yolks. One method of reducing acrylamide content in food may be to add a chickpea protein preparation. The aim of the
Karolina Miśkiewicz +2 more
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The amyloid precursor protein: beyond amyloid.
Molecular neurodegeneration, 2006 The amyloid precursor protein (APP) takes a central position in Alzheimer's disease (AD) pathogenesis: APP processing generates the beta-amyloid (Abeta) peptides, which are deposited as the amyloid plaques in brains of AD individuals; Point mutations and duplications of APP are causal for a subset of early onset of familial Alzheimer's disease (FAD ...
Hui Zheng +3 more
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Fast Proteome Identification and Quantification from Data-Dependent Acquisition - Tandem Mass Spectrometry using Free Software Tools [PDF]
Methods and Protocols 2019, 2018 Identification of nearly all proteins in a system using data-dependent acquisition (DDA) mass spectrometry has become routine for simple organisms, such as bacteria and yeast. Still, quantification of the identified proteins may be a complex process and require multiple different software packages.
arxiv +1 more source
Microbiology SpectrumSweet orange (Citrus sinensis) is one of the most important fruit crops worldwide. Virus infections in this crop can interfere with cellular processes, causing dramatic economic losses. By performing RT-qPCR analyses, we demonstrated that citrus psorosis
Facundo E. Marmisolle +7 more
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Proteasomal degradation competes with Mia40-mediated import into mitochondria
BMC Biology, 2018 Tandem fluorescent protein timers are elegant tools to determine proteolytic stabilities of cytosolic proteins with high spatial and temporal resolution. In a new study published in BMC Biology, Kowalski et al.
Eva Zöller +2 more
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Scientific Reports, 2022 The Cre-loxP system has been widely used for cell- or organ-specific gene manipulation, but it is important to precisely understand what kind of cells the recombination takes place in.
Shinya Ikeda +3 more
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Nature Communications, 2018 The mitochondrial TIM23-complex facilitates anterograde precursor transport across the inner membrane into the matrix and lateral release of precursors into the membrane.
Alexander Benjamin Schendzielorz +7 more
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