Results 31 to 40 of about 29,094 (272)
The Precursor of the α-Fibrous Protein of Epidermis
Extraction of cow snout epidermis with citrate buffer pH 2.65 yields an α-fibrous protein (prekeratin) which can be purified by precipitation at pH 7.0, pH 6.0, pH 5.0 and pH 4.5. A precursor pool of α-fibrous protein has been identified in the microsomal fraction of homogenized tissue and this protein is also soluble in acid buffers at pH 2.65 and ...
Ann M. Gifford+2 more
openaire +3 more sources
Amyloid precursor protein processing and bioenergetics [PDF]
The processing of amyloid precursor protein (APP) to amyloid beta (Aβ) is of great interest to the Alzheimer's disease (AD) field. Decades of research define how APP is altered to form Aβ, and how Aβ generates oligomers, protofibrils, and fibrils. Numerous signaling pathways and changes in cell physiology are known to influence APP processing. Existing
Heather M. Wilkins, Russell H. Swerdlow
openaire +3 more sources
Amyloid Precursor Protein and Alzheimer’s Disease
Alzheimer’s disease (AD) is one of the most common neurodegenerative disorders associated with age or inherited mutations. It is characterized by severe dementia in the late stages that affect memory, cognitive functions, and daily life overall. AD progression is linked to the accumulation of cytotoxic amyloid beta (Aβ) and hyperphosphorylated tau ...
Kseniia S. Orobets, Andrey L. Karamyshev
openaire +2 more sources
Asparagine and reducing sugars are the principal precursors of acrylamide in foods. Their main sources in pastries are flour and hen egg yolks. One method of reducing acrylamide content in food may be to add a chickpea protein preparation. The aim of the
Karolina Miśkiewicz+2 more
doaj +1 more source
The amyloid precursor protein: beyond amyloid.
The amyloid precursor protein (APP) takes a central position in Alzheimer's disease (AD) pathogenesis: APP processing generates the beta-amyloid (Abeta) peptides, which are deposited as the amyloid plaques in brains of AD individuals; Point mutations and duplications of APP are causal for a subset of early onset of familial Alzheimer's disease (FAD ...
Hui Zheng+3 more
openaire +4 more sources
Fast Proteome Identification and Quantification from Data-Dependent Acquisition - Tandem Mass Spectrometry using Free Software Tools [PDF]
Identification of nearly all proteins in a system using data-dependent acquisition (DDA) mass spectrometry has become routine for simple organisms, such as bacteria and yeast. Still, quantification of the identified proteins may be a complex process and require multiple different software packages.
arxiv +1 more source
Sweet orange (Citrus sinensis) is one of the most important fruit crops worldwide. Virus infections in this crop can interfere with cellular processes, causing dramatic economic losses. By performing RT-qPCR analyses, we demonstrated that citrus psorosis
Facundo E. Marmisolle+7 more
doaj +1 more source
Proteasomal degradation competes with Mia40-mediated import into mitochondria
Tandem fluorescent protein timers are elegant tools to determine proteolytic stabilities of cytosolic proteins with high spatial and temporal resolution. In a new study published in BMC Biology, Kowalski et al.
Eva Zöller+2 more
doaj +1 more source
The Cre-loxP system has been widely used for cell- or organ-specific gene manipulation, but it is important to precisely understand what kind of cells the recombination takes place in.
Shinya Ikeda+3 more
doaj +1 more source
The mitochondrial TIM23-complex facilitates anterograde precursor transport across the inner membrane into the matrix and lateral release of precursors into the membrane.
Alexander Benjamin Schendzielorz+7 more
doaj +1 more source