Results 41 to 50 of about 562,686 (340)
Translocation and insertion of precursor proteins into isolated outer membranes of mitochondria [PDF]
, 1993 Nuclear-encoded proteins destined for mitochondria must cross the outer or both outer and inner membranes to reach their final sub- mitochondrial locations. While the inner membrane can translocate preproteins by itself, it is not known whether the outer
Lill, Roland +2 more
core +2 more sources
The Precursor of the α-Fibrous Protein of Epidermis
Journal of Investigative Dermatology, 1971 Extraction of cow snout epidermis with citrate buffer pH 2.65 yields an α-fibrous protein (prekeratin) which can be purified by precipitation at pH 7.0, pH 6.0, pH 5.0 and pH 4.5. A precursor pool of α-fibrous protein has been identified in the microsomal fraction of homogenized tissue and this protein is also soluble in acid buffers at pH 2.65 and ...
Ann M. Gifford +2 more
openaire +3 more sources
The amyloid precursor protein: beyond amyloid.
Molecular neurodegeneration, 2006 The amyloid precursor protein (APP) takes a central position in Alzheimer's disease (AD) pathogenesis: APP processing generates the beta-amyloid (Abeta) peptides, which are deposited as the amyloid plaques in brains of AD individuals; Point mutations and duplications of APP are causal for a subset of early onset of familial Alzheimer's disease (FAD ...
Hui Zheng +3 more
openaire +4 more sources
Microbiology SpectrumSweet orange (Citrus sinensis) is one of the most important fruit crops worldwide. Virus infections in this crop can interfere with cellular processes, causing dramatic economic losses. By performing RT-qPCR analyses, we demonstrated that citrus psorosis
Facundo E. Marmisolle +7 more
doaj +1 more source
Foods, 2020 Asparagine and reducing sugars are the principal precursors of acrylamide in foods. Their main sources in pastries are flour and hen egg yolks. One method of reducing acrylamide content in food may be to add a chickpea protein preparation. The aim of the
Karolina Miśkiewicz +2 more
doaj +1 more source
Scientific Reports, 2021 The pro-homeostatic lipid mediators elovanoids (ELVs) attenuate cell binding and entrance of the SARS-CoV-2 receptor-binding domain (RBD) as well as of the SARS-CoV-2 virus in human primary alveoli cells in culture.
Jorgelina M. Calandria +10 more
doaj +1 more source
Proteasomal degradation competes with Mia40-mediated import into mitochondria
BMC Biology, 2018 Tandem fluorescent protein timers are elegant tools to determine proteolytic stabilities of cytosolic proteins with high spatial and temporal resolution. In a new study published in BMC Biology, Kowalski et al.
Eva Zöller +2 more
doaj +1 more source
Intraneuronal compartments of the amyloid precursor protein [PDF]
The Journal of Neuroscience, 1993 The amyloid precursor protein (APP) is the parent molecule from which beta-amyloid protein is cleaved and deposits as amyloid fibrils in the senile plaques of Alzheimer's disease. Its primary structure resembles a receptor; however, no ligand has been identified. In growing hippocampal neurons APP is localized to growth cones.
Adriana Ferreira +2 more
openaire +3 more sources
Nature Communications, 2018 The mitochondrial TIM23-complex facilitates anterograde precursor transport across the inner membrane into the matrix and lateral release of precursors into the membrane.
Alexander Benjamin Schendzielorz +7 more
doaj +1 more source
FEBS Letters, EarlyView.In vivo IL‐10 produced by tissue‐resident tolDC is involved in maintaining/inducing tolerance. Depending on the agent used for ex vivo tolDC generation, cells acquire common features but prime T cells towards anergy, FOXP3+ Tregs, or Tr1 cells according to the levels of IL‐10 produced. Ex vivo‐induced tolDC were administered to patients to re‐establish/
Konstantina Morali +3 more
wiley +1 more source