Results 41 to 50 of about 322,759 (220)

Elovanoids downregulate SARS-CoV-2 cell-entry, canonical mediators and enhance protective signaling in human alveolar cells

open access: yesScientific Reports, 2021
The pro-homeostatic lipid mediators elovanoids (ELVs) attenuate cell binding and entrance of the SARS-CoV-2 receptor-binding domain (RBD) as well as of the SARS-CoV-2 virus in human primary alveoli cells in culture.
Jorgelina M. Calandria   +10 more
doaj   +1 more source

Motor recruitment to the TIM23 channel’s lateral gate restricts polypeptide release into the inner membrane

open access: yesNature Communications, 2018
The mitochondrial TIM23-complex facilitates anterograde precursor transport across the inner membrane into the matrix and lateral release of precursors into the membrane.
Alexander Benjamin Schendzielorz   +7 more
doaj   +1 more source

Identification of General and Heart-Specific miRNAs in Sheep (Ovis aries).

open access: yesPLoS ONE, 2015
MicroRNAs (miRNAs or miRs) are small regulatory RNAs crucial for modulation of signaling pathways in multiple organs. While the link between miRNAs and heart disease has grown more readily apparent over the past three years, these data are primarily ...
Alessandro Laganà   +6 more
doaj   +1 more source

Smooth muscle protein 22α-Cre recombination in resting cardiac fibroblasts and hematopoietic precursors

open access: yesScientific Reports, 2022
The Cre-loxP system has been widely used for cell- or organ-specific gene manipulation, but it is important to precisely understand what kind of cells the recombination takes place in.
Shinya Ikeda   +3 more
doaj   +1 more source

Heme-oxygenases during erythropoiesis in K562 and human bone marrow cells. [PDF]

open access: yesPLoS ONE, 2011
In mammalian cells, heme can be degraded by heme-oxygenases (HO). Heme-oxygenase 1 (HO-1) is known to be the heme inducible isoform, whereas heme-oxygenase 2 (HO-2) is the constitutive enzyme.
Liliane R Alves   +10 more
doaj   +1 more source

Tracking the Subcellular Localization of Surface Proteins in Staphylococcus aureus by Immunofluorescence Microscopy

open access: yesBio-Protocol, 2021
Surface proteins of Staphylococcus aureus and other Gram-positive bacteria play essential roles in bacterial colonization and host-microbe interactions. Surface protein precursors containing a YSIRK/GXXS signal peptide are translocated across the septal ...
Salvatore Scaffidi, Mac Shebes, Wenqi Yu
doaj   +1 more source

Lactic acid promotes metastatic niche formation in bone metastasis of colorectal cancer

open access: yesCell Communication and Signaling, 2021
Background To investigate the effect of lactic acid (LA) on the progression of bone metastasis from colorectal cancer (CRC) and its regulatory effects on primary CD115 (+) osteoclast (OC) precursors.
Jin Qian   +14 more
doaj   +1 more source

Equilibrium protein adsorption on nanometric vegetable-oil hybrid film/water interface using neutron reflectometry [PDF]

open access: yes, 2020
Nanofilms of thickness of about two nanometers have been formed at the air-water interface using functionalized castor oil (ICO) with cross-linkable silylated groups. These hybrid films represent excellent candidates for replacing conventional polymeric materials in biomedical applications, but they need to be optimized in terms of biocompatibility ...
arxiv   +1 more source

Intestinal gluconeogenesis and glucose transport according to body fuel availability in rats [PDF]

open access: yesJ Physiol 566 (15/07/2005) 575-86, 2007
Intestinal hexose absorption and gluconeogenesis have been studied in relation to refeeding after two different fasting phases: a long period of protein sparing during which energy expenditure is derived from lipid oxidation (phase II), and a later phase characterized by a rise in plasma corticosterone triggering protein catabolism (phase III).
arxiv   +1 more source

Amyloid precursor protein and neural development [PDF]

open access: yesDevelopment, 2014
Interest in the amyloid precursor protein (APP) has increased in recent years due to its involvement in Alzheimer's disease. Since its molecular cloning, significant genetic and biochemical work has focused on the role of APP in the pathogenesis of this disease. Thus far, however, these studies have failed to deliver successful therapies. This suggests
Bassem A. Hassan, Maya Nicolas
openaire   +3 more sources

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