Results 201 to 210 of about 750,523 (310)

Porous Silicon Nanoneedles Efficiently Deliver Adenine Base Editor to Correct a Recurrent Pathogenic COL7A1 Variant in Recessive Dystrophic Epidermolysis Bullosa

Advanced Materials, EarlyView.
Base editing using nanoneedles efficiently corrects pathogenic variants in the type VII collagen gene of primary fibroblasts from patients with recessive dystrophic epidermolysis bullosa. Nanoneedle editing induces minimal and reversible transcriptional perturbations while restoring the production and secretion of functional type VII collagen.
Salman Ahmad Mustfa, Marija Dimitrievska, Cong Wang, Chenlei Gu, Ningjia Sun, Katarzyna Romańczuk, Pawel Karpinski, Łukasz Łaczmański, John A. McGrath, Joanna Jacków‐Malinowska, Ciro Chiappini   +10 more
wiley   +1 more source

Cardiac Organoid Model Inspired Micro‐Robot Smart Patch to Treat Myocardial Infarction

Advanced Materials, EarlyView.
The heart organoid model exhibits the acidic microenvironment characteristic of myocardial infarction, which emerges as a pivotal force propelling the movement of micro‐robots. These micro‐robots, administered through microneedles, can penetrate deep into the tissue, effectively delivering therapeutic payloads to facilitate heart repair.
Fangfang Wang, Zilu Xu, Feiyang Zheng, Dongcheng Yang, Kaige Xu, Ming Ke, Xiao Zhou, Xiaohan Zhang, Ju Tan, Yong Liu, Yansha Hao, Malcolm Xing, Chuhong Zhu   +12 more
wiley   +1 more source

Coupling mechanisms coordinating mRNA translation with stages of the mRNA lifecycle. [PDF]

RNA Biol
Famà V, Coscujuela Tarrero L, Albanese R, Calviello L, Biffo S, Pelizzola M, Furlan M.   +6 more
europepmc   +1 more source

Micro‐ and Nano‐Bots for Infection Control

Advanced Materials, EarlyView.
This review presents a strategic vision for integrating micro‐ and nanobots in the pipeline for infection diagnosis, prevention, and treatment. To develop these robots as a practical solution for infection management, their design principles are clarified based on their propulsion mechanisms and then categorized infection management domains based on ...
Azin Rashidy Ahmady, Shadman Khan, Hong Han, Wei Gao, Zeinab Hosseinidoust, Tohid F. Didar   +5 more
wiley   +1 more source

Sperm-borne mRNAs: potential roles in zygote genome activation and epigenetic inheritance. [PDF]

Open Biol
González B, González CR.
europepmc   +1 more source

Development and Optimization of Micro‐Nanotopographical Platforms for Surface Enhanced Raman Scattering Biomolecular Detection

Advanced Materials Interfaces, EarlyView.
Lithographically defined concentric micro‐ and nanostructures systematically designed and fabricated as reproducible arrays for Surface‐enhanced Raman spectroscopy applications. Abstract Topologically designed micro‐ and nanostructured surface‐enhanced Raman scattering (SERS) substrates propel the advancements of innovative applications, including ...
David Femi Odetade, Jonathan J. S. Rickard, Pola Goldberg Oppenheimer   +2 more
wiley   +1 more source

Arkadia: a new player in hematopoietic stem and progenitor cell development. [PDF]

Haematologica
Ketharnathan S, Berman JN.
europepmc   +1 more source

A Dynamic Double‐Flow Gut‐On‐Chip Model for Predictive Absorption Studies In Vitro

Advanced Materials Technologies, EarlyView.
This study presents a novel millifluidic gut‐on‐chip model using the MIVO® device to replicate human intestinal conditions. Dynamic co‐culture of CaCo‐2 and HT‐29 cells accelerates differentiation, modulates mucus thickness, and enhances barrier function.
Maria Elisabetta Federica Palamà, Maurizio Aiello, Gergő Borka, Jacopo Furci, Ilaria Parodi, Giuseppe Firpo, Silvia Scaglione   +6 more
wiley   +1 more source

ProSIMSIt: The Best of Both Worlds in Data-Driven Rescoring and Identification Transfer. [PDF]

J Proteome Res
Hamood F, Gabriel W, Pfeiffer P, Kuster B, Wilhelm M, The M.   +5 more
europepmc   +1 more source

Synthesis of Unnatural Amino Acids via β‐Aminoaldehyde C–H Arylation using HAT‐Metallaphotoredox Catalysis

Advanced Synthesis &Catalysis, EarlyView.
Abstract Unnatural amino acids play a crucial role in advancing protein engineering and drug development. In this study, we present the synthesis of a series of γ‐aryl‐keto‐α‐amino acids through the direct C−H arylation of readily accessible β‐aminoaldehydes and aryl bromides, promoted by hydrogen atom transfer combined with metallaphotoredox catalysis.
Mariana dos S. Dupim, Bruno M. da S. Santos, Lívia C. R. M. da Frota, Fernanda G. Finelli   +3 more
wiley   +1 more source