Results 221 to 230 of about 215,450 (265)

Effect of triethyllead on post-translational processing of myelin proteins

Experimental Neurology, 1982
Abstract The effect of triethyllead (PbEt3) on entry of newly synthesized proteins into myelin was studied in an in vitro system of brain stem slices prepared from actively myelinating young rats. The slices were incubated 30 min with [3H]leucine then the labeling of proteins was halted by a chase with cold amino acid and the slices were incubated an
G, Konat, H, Offner
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The role of post-translational modification in ϐ-amyloid precursor protein processing

Biochemical Society Symposia, 2001
The ϐ-amyloid precursor protein (APP) plays a pivotal role in the early stages of neurodegeneration associated with Alzheimer's disease. An alteration in the processing pattern of the protein results in an increase in the generation of the 40-42-amino-acid ϐ-amyloid (Aϐ) peptide, which coalesces to form insoluble, extracellular amyloid deposits.
N, Georgopoulou, M, McLaughlin, I, McFarlane, K C, Breen   +3 more
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Post-translational processing of 7S and 11S components of soybean storage proteins

Plant Molecular Biology, 1981
The synthesis and processing of the major storage proteins in soybean cotyledons was studied both in vivo and in vitro. The α and α' subunits of 7S as well as the 11S proteins are synthesized as higher molecular weight-precursors on membrane-bound polysomes.
C, Sengupta, V, Deluca, D S, Bailey, D P, Verma   +3 more
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The effects of manufacture processes on post-translational modifications of bioactive proteins in pertussis vaccine

Journal of Pharmaceutical and Biomedical Analysis, 2020
Because the increasing morbidity of pertussis in all age groups worldwide, the quality of pertussis vaccines has aroused a common concern. To improve the quality of pertussis vaccine in research and production, the effects of manufacture processes on post-translational modifications (PTMs) of bioactive proteins in pertussis vaccine were investigated by
Zhen, Long, Chen, Wei, Zhaoqi, Zhan, Xiuling, Li, Yueqi, Li, Xiao, Ma, Changkun, Li, Lichan, Wang, Taohong, Huang   +8 more
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SYNTHESIS AND POST-TRANSLATIONAL PROCESSING OF SURFACTANT PROTEIN C

Pediatric Pathology & Molecular Medicine, 2001
Traditional thinking about surfactant proteins has centered around their effects on the biophysical properties of surfactant phospholipids. Accumulated data now suggests that the four major surfactant proteins (SPs) are a biochemically and functionally diverse group of mammalian peptides that have function beyond modification of alveolar surface ...
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Impact of post-translational modifications of proteins on the inflammatory process

Biochemical Society Transactions, 2007
PTM (post-translational modification) is the chemical modification of a protein after its translation. The well-studied PTM is phosphorylation, but, recently, PTMs have been re-focused by extensive studies on histone modifications and the discovery of the ubiquitin system.
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In vitro translation, post-translational processing and secretion of pulmonary surfactant protein B precursors

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1989
Surfactant proteolipid SP-B is a hydrophobic protein of Mr = 8000 identified in organic solvent extracts of pulmonary surfactant. Analysis of the human SP-B RNA predicts that the active surfactant peptide is derived by proteolysis of an Mr = 40,000 precursor.
M A, O'Reilly, T E, Weaver, T J, Pilot-Matias, V K, Sarin, A F, Gazdar, J A, Whitsett   +5 more
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Post-translational modified proteins are biomarkers of autoimmune-processes: NETosis and the inflammatory–autoimmunity connection

Clinica Chimica Acta, 2017
Basic research is showing new mechanisms involved in early immune responses and Neutrophil Extracellular Trap (NET) formation (or NETosis) is of key importance as first line defense against bacteria, virus and protozoa. Enzymatic modification of arginine in citrulline in histones is the prerequisite of NETosis being it necessary for decondensation and ...
Bruschi, Maurizio, Petretto, Andrea, Bertelli, Roberta, Galetti, Maricla, Bonanni, Alice, PRATESI, FEDERICO, MIGLIORINI, PAOLA, Candiano, Giovanni, Vaglio, Augusto, Ghiggeri, Gian Marco   +9 more
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Post-Translational Processing of Surfactant Protein-C Proprotein

American Journal of Respiratory Cell and Molecular Biology, 2001
Rat surfactant protein (SP)-C is a 3.7-kD hydrophobic lung-specific protein generated from proteolytic processing of a 21-kD propeptide (SP-C(21)). We have demonstrated that initial post-translational processing of SP-C(21) involves two cleavages of the COOH-terminus (Beers and colleagues, J. Biol. Chem. 1994;269:20,318--20,328).
A L, Johnson, P, Braidotti, G G, Pietra, S J, Russo, A, Kabore, W J, Wang, M F, Beers   +6 more
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Post-translational Proteolytic Processing on Intracellular Proteins by Cathepsins and Cystatins

2010
Post-translational proteolytic modification by limited proteolysis is not only a biological process that produces biologically active proteins (peptides), but because almost all intracellular biologically active proteins are synthesized as pre-pro forms, ordered limited proteolysis by specific proteases is an essential process.
Nobuhiko Katunuma, Masae Takahashi, Tadashi Tezuka   +2 more
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