Results 31 to 40 of about 750,523 (310)

Biosynthesis of intestinal microvillar proteins. The effect of swainsonine on post-translational processing of aminopeptidase N [PDF]

Biochemical Journal, 1983
The post-translational processing of pig small-intestinal aminopeptidase N (EC 3.4.11.2) was studied in organ-cultured mucosal explants. Exposure of the explants to swainsonine, an inhibitor of Golgi mannosidase II, resulted in the formation of a Mr-160000 polypeptide, still sensitive to endo-beta-N-acetylglucosaminidase H.
Danielsen, E M, Cowell, G M, Norén, Ove, Sjöström, H, Dorling, P R   +4 more
openaire   +3 more sources

Post-translational Regulation of Expression and Conformation of an Immunoglobulin Domain in Yeast Surface Display [PDF]

, 2005
Display of heterologous proteins on the surface of Saccharomyces cerevisiae is increasingly being exploited for directed evolution because of straightforward cell screens.
Boder, Eric T, Discher, Dennis E., Parthasarathy, Ranganath, Subramanian, Shyamsundar   +3 more
core   +2 more sources

Consequences of Disease-causing Mutations on Lubricin Protein Synthesis, Secretion, and Post-translational Processing [PDF]

Journal of Biological Chemistry, 2005
Lubricin, a protein product of the gene PRG4, is a secreted mucin-like proteoglycan that is a major lubricant in articulating joints. Mutations in PRG4 cause the autosomal recessive, human disorder camptodactyly-arthropathy-coxa vara-pericarditis syndrome.
Ronald M. Laxer, Raphaela Goldbach-Mansky, Cynthia F. Bartels, Jose Marcelino, Deborah K. Schelling, David K. Rhee, Sulaiman M. Al-Mayouf, Yajun Cui, Matthew L. Warman   +8 more
openaire   +3 more sources

Dissecting ribosomal particles throughout the kingdoms of life using advanced hybrid mass spectrometry methods

Nature Communications, 2018
The authors demonstrate a 3-tier mass spectrometry approach, including bottom-up and top-down proteomics, as well as native mass spectrometry to provide a detailed description of proteoforms, protein processing and post-translational modifications ...
Michiel van de Waterbeemd, Sem Tamara, Kyle L. Fort, Eugen Damoc, Vojtech Franc, Philipp Bieri, Martin Itten, Alexander Makarov, Nenad Ban, Albert J. R. Heck   +9 more
doaj   +1 more source

Post-translational processing of chicken bone phosphoproteins. Identification of bone (phospho)protein kinase [PDF]

Biochemical Journal, 1990
We have detected a protein kinase which phosphorylates bone phosphoproteins (BPPs) in the detergent extract of the membranous fractions in the periosteal bone strips of 12-day-embryonic-chick tibia. This enzyme, tentatively named BPP kinase, has a catalytic subunit of Mr approximately 39,000, utilizes GTP as well as ATP as a phospho-group donor, is ...
Y Mikuni-Takagaki, Melvin J. Glimcher
openaire   +3 more sources

Genomic Variability and Post-translational Protein Processing Enhance the Immune Evasion of Mycoplasma hyopneumoniae and Its Interaction With the Porcine Immune System

Frontiers in Immunology, 2020
Mycoplasma hyopneumoniae (M. hyopneumoniae, Mhp) is a geographically widespread and economically devastating pathogen that colonizes ciliated epithelium; the infection of Mhp can damnify the mucociliary functions as well as leading to Mycoplasma ...
Gaojian Li, Enoch Obeng, Jinqi Shu, Jianhong Shu, Jianhong Shu, Jian Chen, Yuehong Wu, Yulong He   +7 more
doaj   +1 more source

Automated assembly of molecular mechanisms at scale from text mining and curated databases

Molecular Systems Biology, 2023
The analysis of omic data depends on machine‐readable information about protein interactions, modifications, and activities as found in protein interaction networks, databases of post‐translational modifications, and curated models of gene and protein ...
John A Bachman, Benjamin M Gyori, Peter K Sorger   +2 more
doaj   +1 more source

Small antimicrobial resistance proteins (SARPs): Small proteins conferring antimicrobial resistance [PDF]

arXiv, 2023
Small open reading frames are understudied as they have been historically excluded from genome annotations. However, evidence for the functional significance of small proteins in various cellular processes accumulates. Proteins with less than 70 residues can also confer resistance to antimicrobial compounds, including intracellularly-acting protein ...
arxiv  

Diurnal Differences in Human Muscle Isometric Force In Vivo Are Associated with Differential Phosphorylation of Sarcomeric M-Band Proteins

Proteomes, 2020
We investigated whether diurnal differences in muscle force output are associated with the post-translational state of muscle proteins. Ten physically active men (mean ± SD; age 26.7 ± 3.7 y) performed experimental sessions in the morning (08:00 h) and ...
Zulezwan Ab Malik, Kelly A. Bowden Davies, Elliott C. R. Hall, Jennifer Barrett, Samuel A. Pullinger, Robert M. Erskine, Sam O. Shepherd, Zafar Iqbal, Ben J. Edwards, Jatin G. Burniston   +9 more
doaj   +1 more source

Opportunistic proteolytic processing of carbonic anhydrase 1 from Chlamydomonas in Arabidopsis reveals a novel route for protein maturation [PDF]

, 2016
Proteolytic processing of secretory proteins to yield an active form generally involves specific proteolytic cleavage of a pre-protein. Multiple specific proteases have been identified that target specific pre-protein processing sites in animals. However,
Juvale, Parijat, Spalding, Martin, Spalding, Martin, Wagner, Ryan   +3 more
core   +3 more sources