Results 31 to 40 of about 215,450 (265)

Diurnal Differences in Human Muscle Isometric Force In Vivo Are Associated with Differential Phosphorylation of Sarcomeric M-Band Proteins

Proteomes, 2020
We investigated whether diurnal differences in muscle force output are associated with the post-translational state of muscle proteins. Ten physically active men (mean ± SD; age 26.7 ± 3.7 y) performed experimental sessions in the morning (08:00 h) and ...
Zulezwan Ab Malik, Kelly A. Bowden Davies, Elliott C. R. Hall, Jennifer Barrett, Samuel A. Pullinger, Robert M. Erskine, Sam O. Shepherd, Zafar Iqbal, Ben J. Edwards, Jatin G. Burniston   +9 more
doaj   +1 more source

New mechanism for post-translational processing during assembly of a cytoplasmic membrane protein? [PDF]

Journal of Bacteriology, 1981
Insertion of nitrate reductase into the Escherichia coli cytoplasmic membrane was examined by following the fate of pulse-labeled enzyme in both the membrane and cytoplasm during various times after the addition of an unlabeled chase. The polypeptide composition of this labeled enzyme was determined by autoradiography of immunoprecipitated material ...
C H, MacGregor, G E, McElhaney
openaire   +2 more sources

Poly ADP-ribosylation of proteins. Processivity of a post-translational modification.

The Journal of biological chemistry, 1989
The nuclear enzyme poly(ADP-ribose) polymerase (EC 2.4.2.30) participates in DNA excision repair by post-translational selfmodification ("automodification") and the modification of other chromatin proteins ("heteromodification") with ADP-ribose polymers.
H, Naegeli, P, Loetscher, F R, Althaus
openaire   +2 more sources

Inflammasome activation controlled by the interplay between post-translational modifications: emerging drug target opportunities

Cell Communication and Signaling, 2021
Controlling the activation of the NLRP3 inflammasome by post-translational modifications (PTMs) of critical protein subunits has emerged as a key determinant in inflammatory processes as well as in pathophysiology. In this review, we put into context the
Zhu Liang, Andreas Damianou, Elena Di Daniel, Benedikt M. Kessler   +3 more
doaj   +1 more source

Glycosylation and S-palmitoylation regulate SARS-CoV-2 spike protein intracellular trafficking

iScience, 2022
Summary: Post-translational modifications (PTMs), such as glycosylation and palmitoylation, are critical to protein folding, stability, intracellular trafficking, and function.
Chih-Feng Tien, Wan-Ting Tsai, Chun Hwa Chen, Hui-Ju Chou, Mingzi M. Zhang, Jhe-Jhih Lin, En-Ju Lin, Shih-Syong Dai, Yueh-Hsin Ping, Chia-Yi Yu, Yi-Ping Kuo, Wei-Hsiang Tsai, Hsin-Wei Chen, Guann-Yi Yu   +13 more
doaj   +1 more source

Novel biochemistry: post-translational protein splicing and other lessons from the school of antigen processing [PDF]

Journal of Molecular Medicine, 2005
In the past 15 years, the molecular identification of antigens that can mediate the killing of tumor cells by T cells has been vigorously pursued. Molecular identification of tumor-associated antigens not only provided the means to activate or monitor anti-tumor immunity, but also gave insights into new and unexpected biochemical processes that are ...
Ken-ichi, Hanada, James C, Yang
openaire   +2 more sources

How can platelet proteomics best be used to interrogate disease?

Platelets, 2023
Various modifications of proteins and the resulting proteoforms of a protein can associate with many diseases and are also significantly involved in the rapid regulation of hemostasis and thrombosis.
Maria Zellner
doaj   +1 more source

Nonsynonymous Mutations in Intellectual Disability and Autism Spectrum Disorder Gene PTCHD1 Disrupt N-Glycosylation and Reduce Protein Stability

Cells
PTCHD1 has been implicated in Autism Spectrum Disorders (ASDs) and/or intellectual disability, where copy-number-variant losses or loss-of-function coding mutations segregate with disease in an X-linked recessive fashion. Missense variants of PTCHD1 have
Connie T. Y. Xie, Stephen F. Pastore, John B. Vincent, Paul W. Frankland, Paul A. Hamel   +4 more
doaj   +1 more source

Mass spectrometry quantification of clusterin in the human brain

Molecular Neurodegeneration, 2012
Background The multifunctional glycoprotein clusterin has been associated with late-onset Alzheimer’s disease (AD). Further investigation to define the role of clusterin in AD phenotypes would be aided by the development of techniques to quantify level ...
Chen Junjun, Wang Meiyao, Turko Illarion V   +2 more
doaj   +1 more source

STAT3 as a mediator of oncogenic cellular metabolism: Pathogenic and therapeutic implications

Neoplasia: An International Journal for Oncology Research, 2021
The oncogenic transcription factor signal transducer and activator of transcription 3 (STAT3) is activated constitutively in a wide array of human cancers. It is an appealing molecular target for novel therapy as it directly regulates expression of genes
Isidora Tošić, David A. Frank
doaj   +1 more source