Results 51 to 60 of about 215,450 (265)

Cellular electron microscopy imaging reveals the localization of the Hfq protein close to the bacterial membrane.

PLoS ONE, 2009
BackgroundHfq is a bacterial protein involved in several aspects of nucleic acid transactions, but one of its best-characterized functions is to affect the post-transcriptional regulation of mRNA by virtue of its interactions with stress-related small ...
Elia Diestra, Bastien Cayrol, Véronique Arluison, Cristina Risco   +3 more
doaj   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Cellular Processing of the ABCG2 Transporter—Potential Effects on Gout and Drug Metabolism

Cells, 2019
The human ABCG2 is an important plasma membrane multidrug transporter, involved in uric acid secretion, modulation of absorption of drugs, and in drug resistance of cancer cells.
Orsolya Mózner, Zsuzsa Bartos, Boglárka Zámbó, László Homolya, Tamás Hegedűs, Balázs Sarkadi   +5 more
doaj   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Regulation of plant immune receptor accumulation through translational repression by a glycine-tyrosine-phenylalanine (GYF) domain protein

eLife, 2017
Plant immunity is tightly regulated to ensure proper defense against surrounding microbial pathogens without triggering autoimmunity, which negatively impacts plant growth and development.
Zhongshou Wu, Shuai Huang, Xiaobo Zhang, Di Wu, Shitou Xia, Xin Li   +5 more
doaj   +1 more source

Carboxyl-terminal Targeting and Novel Post-translational Processing of JAW1, a Lymphoid Protein of the Endoplasmic Reticulum [PDF]

Journal of Biological Chemistry, 1996
Jaw1 is a lymphoid-restricted protein localized to the cytoplasmic face of the endoplasmic reticulum (ER) and is a member of a recently recognized class of integral membrane proteins that contain carboxyl-terminal membrane anchors. The carboxyl-terminal 71 amino acids of the Jaw1 protein, which contain a hydrophobic membrane spanning region, are ...
Timothy W. Behrens, Grainne Kearns, James J. Rivard, Harris Bernstein, Jonathan W. Yewdell, Louis M. Staudt   +5 more
openaire   +2 more sources

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

RNA-processing protein TDP-43 regulates FOXO-dependent protein quality control in stress response. [PDF]

PLoS Genetics, 2014
Protein homeostasis is critical for cell survival and functions during stress and is regulated at both RNA and protein levels. However, how the cell integrates RNA-processing programs with post-translational protein quality control systems is unknown ...
Tao Zhang, Gerard Baldie, Goran Periz, Jiou Wang   +3 more
doaj   +1 more source

PTG-PLM: Predicting Post-Translational Glycosylation and Glycation Sites Using Protein Language Models and Deep Learning

Axioms, 2022
Post-translational glycosylation and glycation are common types of protein post-translational modifications (PTMs) in which glycan binds to protein enzymatically or nonenzymatically, respectively.
Alhasan Alkuhlani, Walaa Gad, Mohamed Roushdy, Michael Gr. Voskoglou, Abdel-badeeh M. Salem   +4 more
doaj   +1 more source

Integration of circadian and hypoxia signaling via non‐canonical heterodimerization

FEBS Letters, EarlyView.
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley   +1 more source