Results 51 to 60 of about 369,882 (213)

How can platelet proteomics best be used to interrogate disease?

Platelets, 2023
Various modifications of proteins and the resulting proteoforms of a protein can associate with many diseases and are also significantly involved in the rapid regulation of hemostasis and thrombosis.
Maria Zellner
doaj   +1 more source

N-terminal domain on dystroglycan enables LARGE1 to extend matriglycan on α-dystroglycan and prevents muscular dystrophy

eLife, 2023
Dystroglycan (DG) requires extensive post-translational processing and O-glycosylation to function as a receptor for extracellular matrix (ECM) proteins containing laminin-G (LG) domains.
Hidehiko Okuma, Jeffrey M Hord, Ishita Chandel, David Venzke, Mary E Anderson, Ameya S Walimbe, Soumya Joseph, Zeita Gastel, Yuji Hara, Fumiaki Saito, Kiichiro Matsumura, Kevin P Campbell   +11 more
doaj   +1 more source

RNA-binding protein CPEB1 remodels host and viral RNA landscapes. [PDF]

, 2016
Host and virus interactions occurring at the post-transcriptional level are critical for infection but remain poorly understood. Here, we performed comprehensive transcriptome-wide analyses revealing that human cytomegalovirus (HCMV) infection results in
Aigner, Stefan, Ares, Manuel, Batra, Ranjan, Belzile, Jean-Philippe, Bos, Tomas J, Clark, Elizabeth, Donohue, John Paul, Gelboin-Burkhart, Chelsea, Huang, Hui, Huelga, Stephanie C, Rigo, Frank, Roberts, Brett T, Sathe, Shashank, Spector, Deborah H, Stark, Thomas J, Wheeler, Emily C, Yee, Brian A, Yeo, Gene W   +17 more
core   +2 more sources

Nonsynonymous Mutations in Intellectual Disability and Autism Spectrum Disorder Gene PTCHD1 Disrupt N-Glycosylation and Reduce Protein Stability

Cells
PTCHD1 has been implicated in Autism Spectrum Disorders (ASDs) and/or intellectual disability, where copy-number-variant losses or loss-of-function coding mutations segregate with disease in an X-linked recessive fashion. Missense variants of PTCHD1 have
Connie T. Y. Xie, Stephen F. Pastore, John B. Vincent, Paul W. Frankland, Paul A. Hamel   +4 more
doaj   +1 more source

Genome wide comparative analysis of the effects of PRMT5 and PRMT4/CARM1 arginine methyltransferases on the Arabidopsis thaliana transcriptome [PDF]

, 2015
BACKGROUND: Methylation at arginine residues (R) is an important post-translational modification that regulates a myriad of essential cellular processes in eukaryotes, such as transcriptional regulation, RNA processing, signal transduction and DNA repair.
Hernando, Carlos Esteban, Mancini, Estefania, Sanchez, Sabrina Elena, Yanovsky, Marcelo Javier   +3 more
core   +1 more source

Novel biochemistry: post-translational protein splicing and other lessons from the school of antigen processing [PDF]

Journal of Molecular Medicine, 2005
In the past 15 years, the molecular identification of antigens that can mediate the killing of tumor cells by T cells has been vigorously pursued. Molecular identification of tumor-associated antigens not only provided the means to activate or monitor anti-tumor immunity, but also gave insights into new and unexpected biochemical processes that are ...
Hanada, Ken-Ichi, Yang, James C.
openaire   +3 more sources

Research progress of Nedd4L in cardiovascular diseases

Cell Death Discovery, 2022
Post-translational modifications (PTMs) are a covalent processing process of proteins after translation. Proteins are capable of playing their roles only after being modified, so as to maintain the normal physiological function of cells.
Mohan Li, Guozhe Sun, Pengbo Wang, Wenbin Wang, Kexin Cao, Chunyu Song, Yingxian Sun, Ying Zhang, Naijin Zhang   +8 more
doaj   +1 more source

The Histone 3'-Terminal Stem-Loop-Binding Protein Enhances Translation through a Functional and Physical Interaction with Eukaryotic Initiation Factor 4G (eIF4G) and eIF3 [PDF]

, 2002
Metazoan cell cycle-regulated histone mRNAs are unique cellular mRNAs in that they terminate in a highly conserved stem-loop structure instead of a poly(A) tail.
Gallie, Daniel R, Ling, Jun, Marzluff, William F, Morley, Simon J, Pain, Virginia M   +4 more
core   +4 more sources

Modifications and Trafficking of APP in the Pathogenesis of Alzheimer’s Disease

Frontiers in Molecular Neuroscience, 2017
Alzheimer’s disease (AD), the most common neurodegenerative disorder, is the leading cause of dementia. Neuritic plaque, one of the major characteristics of AD neuropathology, mainly consists of amyloid β (Aβ) protein.
Xin Wang, Xin Wang, Xuan Zhou, Xuan Zhou, Gongying Li, Gongying Li, Gongying Li, Yun Zhang, Yili Wu, Yili Wu, Yili Wu, Yili Wu, Weihong Song   +12 more
doaj   +1 more source

STAT3 as a mediator of oncogenic cellular metabolism: Pathogenic and therapeutic implications

Neoplasia: An International Journal for Oncology Research, 2021
The oncogenic transcription factor signal transducer and activator of transcription 3 (STAT3) is activated constitutively in a wide array of human cancers. It is an appealing molecular target for novel therapy as it directly regulates expression of genes
Isidora Tošić, David A. Frank
doaj   +1 more source