Results 71 to 80 of about 750,523 (310)

Fe65 Is Phosphorylated on Ser289 after UV-Induced DNA Damage [PDF]

, 2016
Fe65 undergoes a phosphatase-sensitive gel mobility shift after DNA damage, consistent with protein phosphorylation. A recent study identified Ser228 as a specific site of phosphorylation, targeted by the ATM and ATR protein kinases, with phosphorylation
Blain, Peter G., Jowsey, Paul, Lakshmana, Madepalli K., Langlands, Hannah   +3 more
core   +2 more sources

Structural and mechanistic basis for the regulation of the chloroplast signal recognition particle by (p)ppGpp

FEBS Letters, EarlyView.
LHCPs are transported to the thylakoid membrane via the (cp)SRP pathway. This process involves a transit complex of (cp)SRP43, (cp)SRP54 and LHCP, which interacts with (cp)FtsY and Alb3 at the membrane. GTP hydrolysis by (cp)SRP54 and (cp)FtsY triggers complex dissociation.
Victor Zegarra, Paul Weiland, Pauline Anka Plitzko, Julia Thiery, Laura Czech, Felix Willmund, Patricia Bedrunka, Gert Bange   +7 more
wiley   +1 more source

Regulation of plant immune receptor accumulation through translational repression by a glycine-tyrosine-phenylalanine (GYF) domain protein

eLife, 2017
Plant immunity is tightly regulated to ensure proper defense against surrounding microbial pathogens without triggering autoimmunity, which negatively impacts plant growth and development.
Zhongshou Wu, Shuai Huang, Xiaobo Zhang, Di Wu, Shitou Xia, Xin Li   +5 more
doaj   +1 more source

Rescue of Heart Failure by Mitochondrial Recovery [PDF]

International Neurourology Journal, 2016
Heart failure (HF) is a multifactorial disease brought about by numerous, and oftentimes complex, etiological mechanisms. Although well studied, HF continues to affect millions of people worldwide and current treatments can only prevent further ...
Jubert Marquez, Sung Ryul Lee, Nari Kim, Jin Han   +3 more
doaj   +1 more source

PTG-PLM: Predicting Post-Translational Glycosylation and Glycation Sites Using Protein Language Models and Deep Learning

Axioms, 2022
Post-translational glycosylation and glycation are common types of protein post-translational modifications (PTMs) in which glycan binds to protein enzymatically or nonenzymatically, respectively.
Alhasan Alkuhlani, Walaa Gad, Mohamed Roushdy, Michael Gr. Voskoglou, Abdel-badeeh M. Salem   +4 more
doaj   +1 more source

A mini-review of the diffusion dynamics of DNA-binding proteins: Experiments and models [PDF]

, 2020
In the course of various biological processes, specific DNA-binding proteins must find a particular target sequence/protein or a damaged site on the DNA efficiently. DNA-binding proteins perform this task based on diffusion. Yet, investigations over recent decades have found that the diffusion dynamics of DNA-binding proteins are generally complicated ...
arxiv   +1 more source

Post-translational Processing and Turnover Kinetics of Presynaptically Targeted Amyloid Precursor Superfamily Proteins in the Central Nervous System [PDF]

Journal of Biological Chemistry, 1998
The amyloid precursor superfamily is composed of three highly conserved transmembrane glycoproteins, the amyloid precursor protein (APP) and amyloid precursor-like proteins 1 and 2 (APLP1, APLP2), whose functions are unknown. Proteolytic cleavage of APP yields the betaA4 peptide, the major component of cerebral amyloid in Alzheimer's disease.
Annamaria Confaloni, Annamaria Confaloni, Sangram S. Sisodia, Kenneth L. Moya, Kenneth L. Moya, Gopal Thinakaran, Alvin W. Lyckman   +6 more
openaire   +3 more sources

Posttranslational modifications of GLUT4 affect its subcellular localization and translocation [PDF]

, 2013
The facilitative glucose transporter type 4 (GLUT4) is expressed in adipose and muscle and plays a vital role in whole body glucose homeostasis. In the absence of insulin, only ~1% of cellular GLUT4 is present at the plasma membrane, with the vast ...
Bayer, Begum, Birnbaum, Bogan, Bogan, Bogan, Bryant, Cassie Welburn, Chang, Fujita, Garvey, Gill, Giorgino, Govers, Grasbon-Frodl, Gwyn Gould, Haga, Hardy, Herrmann, Hicke, Huang, Ing, James, James, Jessica Sadler, Jeyaraj, Karylowski, Kupriyanova, Lamb, Lau, Lawrence, Lawrence, Leto, Li, Liu, Livingstone, Mahajan, Marsh, Marshall, Marshall, Martin, Matunis, McCormick, Muller, Nia Bryant, Perera, Pessin, Pilch, Piper, Ren, Reusch, Saltiel, Semiz, Shi, Shi, Stöckli, Toh, Urbe, Vannucci, Varki, Watson, Williams, Yang, Yu, Zaarour   +64 more
core   +3 more sources

The multiple roles of the NlpC_P60 peptidase family in mycobacteria – an underexplored target for antimicrobial drug discovery

FEBS Letters, EarlyView.
The NlpC_P60 superfamily of peptidases is recognised by its key role in bacterial cell wall homeostasis. Recently, studies have also described the involvement of NlpC_P60‐like enzymes in bacterial competitive mechanisms and pathogenesis across several lineages.
Catharina dos Santos Silva, Marcio Vinicius Bertacine Dias   +1 more
wiley   +1 more source

Cellular Processing of the ABCG2 Transporter—Potential Effects on Gout and Drug Metabolism

Cells, 2019
The human ABCG2 is an important plasma membrane multidrug transporter, involved in uric acid secretion, modulation of absorption of drugs, and in drug resistance of cancer cells.
Orsolya Mózner, Zsuzsa Bartos, Boglárka Zámbó, László Homolya, Tamás Hegedűs, Balázs Sarkadi   +5 more
doaj   +1 more source