Results 131 to 140 of about 56,029 (251)

Global Analysis of Apicomplexan Protein S‐Acyl Transferases Reveals an Enzyme Essential for Invasion

Traffic, 2013
SynopsisSpiderweb‐like gelatine matrices generated by electrospinning are introduced as versatile substrate for culturing animal cell monolayers destined for cryofixation and EM. Thus, non‐disruptive sampling and transfer of native cells into high‐pressure freezing devices is possible within about 30 seconds.
Frenal, Karine, Tay, Chwen L, Mueller, Christina, Bushell, Ellen S, Jia, Yonggen, Graindorge, Arnault, Billker, Oliver, Rayner, Julian C, Soldati-Favre, Dominique   +8 more
openaire   +5 more sources

Screening anticancer peptides performance in organotypic prostate tumor‐stroma 3D models

International Journal of Cancer, EarlyView.
What's New? Peptide‐based drugs have emerged as promising anticancer therapies for their potential to disrupt protein–protein interactions. In this study, the authors developed a physiomimetic human 3D prostate cancer spheroid model to assess the efficacy of the CAVPENET peptide in inhibiting tumor growth. Upon incubation with CAVPENET, prostate cancer
Bárbara Matos, Maria V. Monteiro, Matilde R. Lagarto, John Howl, Carmen Jerónimo, Vítor M. Gaspar, João F. Mano, Margarida Fardilha   +7 more
wiley   +1 more source

Development of a novel high-throughput screen for the identification of new inhibitors of protein S-acylation. [PDF]

J Biol Chem, 2022
Salaun C, Takizawa H, Galindo A, Munro KR, McLellan J, Sugimoto I, Okino T, Tomkinson NCO, Chamberlain LH.   +8 more
europepmc   +1 more source

Gut microbiome‐derived metabolites show promise in cancer research and therapy

Interdisciplinary Medicine, EarlyView.
The metabolites produced by the gut microbiome, which are subject to regulation by multiple factors, play a pivotal role in the progression of various types of cancer. These metabolites not only function as potential biomarkers for the early detection and monitoring of tumor development, but also actively participate in cancer therapeutic processes ...
Kangjie Yang, Yifan Wang, Daolin Tang, Peilong Li, Lutao Du   +4 more
wiley   +1 more source

Triacylglycerol synthesis in rat adipose tissue : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Biochemistry at Massey University [PDF]

, 1983
Adipose tissue consists of two types of cell; the adipocyte and the non-adipocyte {Rodbell, 1964). The adipocyte is unique amongst mammalian cell types in that one class of component {TG) comprises up to 80% of its weight.
Wilson, Russell Douglas
core  

Data‐Driven Engineering of Thermostable Collagen‐Mimetic Peptoid Triple Helices

Macromolecular Rapid Communications, EarlyView.
Data‐driven active learning discovery of collagen‐mimetic peptoids capable of forming a thermostable collagen‐like triple helix using computational screening followed by experimental validation. ABSTRACT Collagen‐mimetic peptides (CMPs) are engineered molecules designed to replicate the triple‐helical structure of natural collagen.
Alex Berlaga, Renyu Zheng, Zeqian Zhang, Junhee Lee, Diya Gandhi, Chun‐Long Chen, Andrew L. Ferguson   +6 more
wiley   +1 more source

An atlas of Arabidopsis protein S-acylation reveals its widespread role in plant cell organization and function. [PDF]

Nat Plants, 2022
Kumar M, Carr P, Turner SR.
europepmc   +1 more source

Analytical Approaches to Address Challenges in the Analysis of Cannabinoids in Vascular Matrices Using Mass Spectrometry

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Phytocannabinoids are bioactive metabolites derived from the Cannabis sativa plant. They have garnered attention due to their recreational uses and therapeutic potential. Although various analytical strategies have been employed for their analysis, mass spectrometry (MS) coupled to chromatographic separation is superior due to its sensitivity ...
Radwa Mahmoud, Robert B. Laprairie, Anas El‐Aneed   +2 more
wiley   +1 more source

Genome-wide identification, structural analysis, and heterologous functional inference of FvPAT10, a protein S-acyl transferase in woodland strawberry (Fragaria vesca)

BMC Plant Biology
Background Protein S-acyl transferases (PATs) mediate S-acylation, a reversible post-translational modification that attaches long-chain lipids, typically palmitate, to cysteine residues, thereby impacting protein trafficking, membrane association ...
Maryam Shahbazi, Alireza Motallebi-Azar, Antonio Masi, Nasser Mahna   +3 more
doaj   +1 more source

Tuning adsorption and morphology in poly(glutamic acid) via controlled acidic partial deprotection

Polymer International, EarlyView.
Partial deprotection of poly(glutamic acid) generates morphologies and assemblies that match fully deprotected polypeptides in small‐molecule adsorption, extending to block copolypeptides with pH‐dependent effects. Abstract Synthetic polypeptides prepared from N‐carboxyanhydride (NCA) monomers are important platforms for environmental and medical ...
Hunter Wood, Stella Trickett, Joseph Dosch, Farin Weinger, Dan Flaherty, Stefanie Sydlik   +5 more
wiley   +1 more source