Results 61 to 70 of about 6,885 (176)

Metal‐dependent regulated cell death: Molecular architecture and translational frontiers

iMeta, EarlyView.
Intracellular metal dyshomeostasis orchestrates distinct regulated cell death programs, including iron‐driven ferroptosis, copper‐mediated cuproptosis, calcicoptosis, newly designated zincoptosis, mnoptosis, and coptosis. This review systematically delineates their molecular architectures—spanning from Sorafenib‐induced lipid peroxidation and ...
Haoliang Hu, Zhe Chen, Yaqi Li, Jiayi Peng, Jiangang Cao, Hong Zhou, Mengqi Wang, Yuejia Du, Hailin Wu, Huiqin Zhao, Shifang Huang, Dianmei Yu, Meiqing Liu, Olga V. Shevchenko, Natalia Yu. Matveeva, Yiyuan Yang, Kerui Huang, Deguan Lv, Junxia Min, Linxi Chen, Fudi Wang   +20 more
wiley   +1 more source

Signalling by NO-induced protein S-nitrosylation and S-glutathionylation: Convergences and divergences [PDF]

Cardiovascular Research, 2007
The role of nitric oxide in several signalling routes has been clearly established. In recent years increasing attention has been paid to its ability to produce covalent protein post-translational modifications in conjunction with other reactive oxygen and nitrogen species.
Martínez Ruiz, Antonio, Lamas, Santiago
openaire   +3 more sources

Protein S-glutathionylation levels in control dogs and in dogs infused with sodium nitrite.

, 2015
Compared with controls, there was an increase in protein S-glutathionylation in dogs that had been infused with sodium nitrite prior to occlusion (NaNO2-PO group), as determined via Western immunoblot with an anti-glutathionylation antibody.
Attila Kiss (619090), József Kaszaki (618316), Mária Kovács (729488), György Seprényi (729491), Mark J. Kohr (649470), Elizabeth Murphy (649471), Ágnes Végh (729492), Márton Gönczi (729489), Gottfried Miskolczi (729490)   +8 more
core   +1 more source

S-glutathionylation reactions in mitochondrial function and disease

Frontiers in Cell and Developmental Biology, 2014
Mitochondria are highly efficient energy-transforming organelles that convert energy stored in carbon bonds into the universal energy currency ATP. The production of ATP by mitochondria is dependent on oxidation of nutrients and coupling of exergonic ...
Ryan J. Mailloux, William G. Willmore
doaj   +1 more source

Ion Activation Methods for Top‐Down Proteomics

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Mass spectrometry (MS) has emerged as a premier method used to characterize the sequences of proteins. Top‐down proteomics aims to capture the multiple sources of structural diversity reflected in proteins, such as those that arise from alternative RNA splicing events or the addition of post‐translational modifications. Tandem MS (i.e., MS/MS)
Jada N. Walker, Jennifer S. Brodbelt
wiley   +1 more source

Role of Glutaredoxin-Mediated Protein S-Glutathionylation in Cellular Nitroglycerin Tolerance [PDF]

The Journal of Pharmacology and Experimental Therapeutics, 2009
We hypothesize that nitroglycerin (NTG) causes direct oxidation of multiple cellular sulfhydryl (SH) proteins and that manipulation of SH redox status affects NTG tolerance. In LLC-PK1 cells, we found that nitrate tolerance, as indicated by cGMP accumulation toward NTG, was accompanied by increased protein [(35)S]cysteine incorporation, significant S ...
Pei-Suen, Tsou, Vamsi, Addanki, Jessica A, Haas, Nathaniel A, Page, Ho-Leung, Fung   +4 more
openaire   +2 more sources

Molecular mechanisms and potential clinical significance of S-glutathionylation

, 2008
Protein S-glutathionylation, the reversible binding of glutathione to protein thiols (PSH), is involved in protein redox regulation, storage of glutathione, and protection of PSH from irreversible oxidation.
A. Milzani, D. Giustarini, Nicoletta Gagliano, Aldo Milzani, Daniela Giustarini, R. Rossi, Isabella Dalle–Donne, I. Dalle-Donne, Roberto Colombo, N. Gagliano, Ranieri Rossi, R. Colombo   +11 more
core   +2 more sources

Russian wheat aphid: a model for genomic plasticity and a challenge to breeders

Insect Science, EarlyView.
Invasive foundress finds suitable habitat and reproduces through pathogenesis. Wingless females produce life offspring quickly, which leads to high population densities. High population densities result in competition, which may induce epigenetic changes and wing development for dispersal.
Astrid Jankielsohn, Vicky L. Tolmay, Marlon‐Schylor Luke le Roux, Lintle Mohase, Mpho S. Mafa, Vittorio F. Nicolis, Eduard Venter, Nicolaas Francois Visser Burger, Anna‐Maria Botha   +8 more
wiley   +1 more source

A cross‐species post‐translational modification profiling of histones by LC‐MS/MS revealed conserved oxidative modifications in plants

New Phytologist, EarlyView.
Conservation of post‐translational modifications (PTMs) in histones across six plant species.
Sau‐Shan Cheng, Wai‐Ching Sin, Yuen‐Yi Chau, Hon‐Ming Lam   +3 more
wiley   +1 more source

Canonical and non‐canonical functions of proteins regulating mitochondrial dynamics in mammalian physiology

The Journal of Physiology, EarlyView.
Abstract figure legend Mitochondria are highly dynamic organelles that continuously remodel their architecture through coordinated cycles of fusion and fission. This review examines the four key GTPases that orchestrate mitochondrial dynamics in mammals: MFN1, MFN2, OPA1, and DRP1.
Rémi Chaney, Vincent Marcangeli, Krystel Desjardins, Shima Taherkhani, Gilles Gouspillou   +4 more
wiley   +1 more source